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Biomedical subjects

P Mathieu

Publications and source records attributed to P Mathieu.

At least 181 records · Page 10Linked to original sources
PubMed1983

[Contribution of surgery in advanced valvular diseases].

Technical advances and progress in resuscitation over the last ten years have led to an appreciable improvement in the surgical results of valve replacements. However, it appears that the decision to operate is sometimes difficult in cases of advanced valvular disease. A study of the literature and our own experience lead us believe that despite a significant peri-operative mortality, surgical treatment remains the best form of treatment for these types of valvular disease, whether aortic, mitral or multivalvular. Surgery ensures a longer survival of better quality than does medical treatment. A better understanding of the natural history of valvular disease should enable us to refer those patients to surgeons who will benefit most from a valve replacement.

Heart Valve Diseases↗
PubMed1983

[Criteria of operability for advanced valvular diseases].

Despite the advances made in cardiac surgery, there are still some cases of valvular disease which remain inoperable, i.e. patients who present an operative risk which is too high in relation to the natural history of the disease. A study of the literature does not enable us to define objective clinical or investigational parameters of inoperability, but only factors of poor prognosis. Although there does not appear to be any cardiac contra-indications to valve replacement in cases of advanced valvular disease, the authors stress the importance of the patients general condition which determines the post-operative prognosis and the need for a better definition of the criteria of poor prognosis so that surgery can be performed before it is too late.

Echocardiography↗
PubMed1981

Localization of relaxin in human gestational corpus luteum.

Corpora lutea from 12 pregnant women were prepared for immunohistochemical localization of relaxin using a highly specific antiserum. A positive response is given by luteal cells that are diffusely distributed throughout the corpus luteum. These cells do not form a distinctive group in any particular area. A negative response is seen in the adjacent ovarian tissue, and also in nongestational corpora lutea in early luteal phase.

Animals↗
PubMed1981

[Medical treatment of ilio-caval venous thrombosis].

120 patients with ilio-caval thrombosis were managed medically. 55 patients were given heparin (5 mg/Kg/day for 15 days), 50 patients received streptokinase (loading dose 250,000 u; maintenance dose 100,000 m/h for 48 hours) and 15 patients had urokinase (112,500 u/h for 44 hours). Thrombolytic therapy was prescribed, in the absence of contraindications, for patients below 70 year of age: other patients were treated with heparin. The results were assessed by venography performed before and after treatment: success was defined as the complete disappearance of the thrombus of disobliteration of the ilio-caval axis. The overall success rate was 32%, with 68% failures. Success was higher with streptokinase (50%) than with heparin (20%) or urokinase (13%). The site, extension ans aetiology of the thrombosis did not affect the results. On the other hand, two other factors seemed to play an important role: - the duration of thrombosis: this only affected the streptokinase group; 23 of the 25 successes were obtained in patients treated before the tenth day. The results were unaffected by the duration of the thrombosis in the heparin group; - the biological effectiveness of therapy: 7 out of the 11 successes in the heparin group had been constantly well anticoagulated; there were only 4 successes out of 38 patients in whom the biological effectiveness had been intermittent. There were 21 successes out of 32 patients treated by streptokinase with serum fibrin levels of less than 1 g. There were only 4 successes in the 18 other cases. The incidence of haemorrhage was identical in the 3 groups. Embolism was slightly commoner in the streptokinase (3) than in the heparin group (2).

Adult↗
PubMed1981

[Ascending venous angiopneumography. A new method of exploration in pulmonary embolism].

Selective angiopneumography is considered to be the best diagnostic investigation for pulmonary embolism. However, the technique has to be performed in a specialised unit, is associated with a certain degree of risk and does not explore the lower limb veins which are the usual site of migratory thrombi. The authors have therefore developed a new angiographic technique, ascending venous angiopneumography (AVAP) which successively opacifies the lower limb veins, inferior vena cava (IVC) and pulmonary arteries. It was used in 180 patients suspected of having a recent pulmonary embolism. It has three main advantages: 1) TECHNIQUE: this only involves injection of a vein on the dorsum of the foot, may be carried out in any radiological centre and is repeatable. 2) DIAGNOSIS: the investigation is more sensitive but less specific than selective angiopneumography when compared in a series of 25 cases: it was never normal in the 16 cases of pulmonary embolism, but in its absence there were 4 doubtful cases out of 8. This lack of specificity is compensated by the data obtained during the initial phlebocavographic times. The diagnosis of pulmonary embolism may be made when the context is suggestive and radiological evidence of venous thrombosis is obtained (124 cases). The diagnosis is very improbable when all phases of AVAP are normal (45 cases). 3) THERAPY: treatment should take the initial venous thrombosis into account, especially with regards to the choice of thrombolytic agents and surgical clipping of the IVC. Finally, this is a low-risk procedure.

Angiography↗
PubMed1981

[Prognosis of chronic post-traumatic thoracic aorta aneurysms in 15 patients (author's transl)].

False chronic post-traumatic aneurysms of the ascending aorta were detected in 15 patients. These aneurysms were false because only a few cells were present in their walls: it is only after survival for more than 3 weeks tht one can speak of chronic aneurysms, and only 5% of the injured patients survived for this period of time. The lesions show marked progression for one year, but rupture of apparently quiescent aneurysms may occur up to 20 years after the initial injury. The prognosis of these lesions is therefore comparable with that of other aortic aneurysms. Cardiovascular surgery has progressed to such an extent, and the risks are so low (0% in this series), that surgical correction should be systematically considered.

Adolescent↗
PubMed1980

[Plasma separation with membranes--examinations in man (author's transl)].

Plasma separation was carried out using a new cellullose diacetate hollow-fibre module. The pore size of the membranes used was 0.2 micrometer and the cut-off at approximately 3 million dalton. Five litres of filtrate was separated in 80 min. The protein content of the filtrate was 60% of that in the blood plasma. When plasma and filtrate were compared, there was little difference inthe proportions of the immunoglobulins. At the end of treatment, the immunoglobulin content of the plasma had been reduced to 40% of its initial concentration.

Animals↗
PubMed1980

The 4-O-methylation pathway of catecholamines: search for an in vivo production of 3-hydroxy,4-methoxyphenylglycol (iso-MHPG).

The existence of 3-hydroxy,4-methoxyphenylglycol in biological fluids has been investigated. 4-Hydroxy,3-methoxy-phenylglycol (MHPG) and 3-hydroxy,4-methoxyphenylglycol (iso-MHPG) have been separated from each other by gas-liquid chromatography of their heptafluorobutyryl derivatives, using an electron capture detector procedure. Urines of normal subjects, of patients with secreting nervous tissue tumors and human cerebrospinal fluids were analyzed. Iso-MHPG was never detected, with the exception of trace amounts in one urinary sample from a patient with a peculiarly high excretion of MHPG. It is concluded that norepinephrine is probably not 4-O-methylated in vivo, contrary to dopamine which is known to lead, at least to a small extent, to 4-O-methylated metabolites.

Chromatography, Gas↗