Search PubMed⌕ Search

Biomedical subjects

P Martin

Publications and source records attributed to P Martin.

At least 955 records · Page 53Linked to original sources
PubMed1978

Tolerance to delta9-tetrahydrocannabinol in adapted and nonadapted rabbits.

Two groups of New Zealand white rabbits, one which had been adapted to the testing chamber and one which had not been adapted to the testing chamber, were given delta9-tetrahydrocannabinol (delta9-THC; 0.5 mg/kg, IV) daily for 12 days. During vehicle control and on the first and last day of delta9-THC administration, electroencephalograms (EEG's) were recorded from the motor cortex and hippocampus, while standing, sprawling and behavioral activity were recorded concurrently. The results showed that tolerance to the behavioral and EEG effects of delta9-THC occurs in rabbits and that acute and chronic effects produced by delta9-THC are influenced by environmental factors.

Adaptation, Psychological↗
PubMed1978

Concentrations of patch test allergens: are we comparing the same things?

A new way of expressing the concentrations of patch test allergens solutions (or emulsions) is proposed. From these new expressions it can be seen that apparently similar concentrations (0.5% chromium, 2% formaldehyde) can actually be in the ratio 1 to 15 as expressed at the molecular level.

Allergens↗
PubMed1978

Gastric emptying rates of solid food in relation to body size.

The relationship of body size to rates of gastric emptying of solid food was investigated in order to obtain data that may allow this variable to be considered when populations of varying size are studied. Rates of gastric emptying were measured using a beef stew meal to which were added pieces of chicken liver tagged with [99mTc]sulfur colloid, and following the passage of the isotope through the gastrointestinal tract with intermittent gamma-imaging. Results showed an inverse linear relationship between gastric emptying rates and body surface area, and between gastric emptying rates and body weight. The variable of body size must be taken into account when measurements of gastric emptying of solid food are measured.

Adult↗
PubMed1978

Interactions between digoxin and brief vagal bursts influencing atrioventricular conduction.

The interaction between intravenous injections of digoxin (20 microgram/kg every 15 minutes) and brief electrical bursts of vagal stimulation was determined in chloralose-anesthetized dogs. Vagal effect curves were generated to characterize the effect of brief vagal stimulus bursts on atrioventricular conduction. These curves were fit with an analytic expression from which the following parameters were derived as the experimental observations: 1) the maximal change in atrioventricular conduction (deltaPRmax), 2) the time after the stimulus at which atrioventricular conduction was maximally inhibited (Tmax) and 3) the width of the vagal effect curve at one-half the maximal amplitude (TD). Digoxin administration significantly (P less than .05) increased deltaPRmax, Tmax and TD by 21.6 +/- 4.3, 50.0 +/- 16.1 and 125.5 +/- 42.4 msec, respectively, before the disruption of sinus rhythm. Diluent or saline administration did not alter deltaPRmax, Tmax or TD. In addition, digoxin produced dose-dependent increases in deltaPRmax. These results suggest that digoxin vagal interactions not only affect the PR interval but also the time to the maximum delay in atrioventricular conduction and the length of time for depressed conduction after brief bursts of vagal activity.

Animals↗
PubMed1978

[The true error and the attributed error: analysis of the causes and remedies from specimen collection to response].

After a brief definition of accidental, systematic error and blunder, the AA. analyse the causes and remedies of the error, before and during the laboratory stage. During the latter they analyse the manual and automatic steps of the tests. The AA. conclude that the modern laboratory is a very efficient and sometimes resolving means in order to formulate a diagnosis. It's not the diagnosis.

Autoanalysis↗
PubMed1977

Diabetic nephropathy.

Explore the source record for details and available documents.

Diabetes Mellitus, Type 1↗
PubMed1977

The medium term results after profundaplasty.

The medium term results of 112 profundaplasties for lower limb ischaemia are reviewed for periods of up to 9 years after operation. Death from cardiovascular causes was found to be more common than subsequent amputation. Though immediate relief from symptoms was not so dramatic as after a femoropopliteal graft, the longer term results showed a much lower late amputation rate. The only resonable operation for failure of a previous femoropopliteal graft appears to be a profundaplasty.

Amputation, Surgical↗
PubMed1977

Nuclear DNA synthesis in yeast and the effect of irradiation.

The synthesis of DNA can be measured in yeast by following the uptake of 5-bromodeoxy-uridine-5'-triphosphate in a mutant that utilizes deoxythymidine-5'-monophosphate; approximately 60 per cent of the DNA is synthesized semi-conservatively before replication stops. Neither ultraviolet light (U.V.), nor ionizing radiation stimulates repair-type synthesis. Based on the ability to detect small amounts of synthesis, it appears that fewer than ten bases are synthesized per pyrimidine dimer removed.

Cell Nucleus↗