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Biomedical subjects

P Long

Publications and source records attributed to P Long.

53 records · Page 3Linked to original sources
PubMed1977

The effect of anti-lipolytic agents on isoprenaline-induced myocardial necrosis in the rat.

The effect of inhibiting isoprenaline-induced lipolysis on the degree of damage produced in the rat myocardium by this amine has been investigated by pre-dosing rats with the anti-lipolytic agent 5-fluoro-nicotinic acid. The degree of myocardial necrosis produced in animals given isoprenaline alone and those pre-dosed with the anti-lipolytic agent was measured by the use of an automated flying spot microscope to show absence of formazan from dead muscle fibres in sections treated to demonstrate succinic dehydrogenase. The use of the anti-lipolitic considerably reduced the degree of myocardial damage produced by a standard dose of isoprenaline bitartrate. This was associated with an inhibition of the post-isoprenaline rise in plasma free fatty acid levels. The results are discussed in relation to the possible protective roles of the lowering of plasma free fatty acid levels and inhibition of the adenyl cyclase system at the plasma membrane of the myocardial cell produced directly by the anti-lipolytic.

Animals↗
PubMedDate not supplied

Transjugular core liver biopsy with a 19-gauge spring-loaded cutting needle.

One hundred and five sequential transjugular core liver biopsies (TJLBx) were performed in 101 patients with coagulopathy and/or ascites using the 19-gauge Quick-Core Biopsy (QCB) needle. Two-hundred and seventy-three cores were obtained in 295 passes (92. 5%). One-hundred and two of the 105 procedures (97.1%) led to a histopathologic diagnosis. One of the three nondiagnostic biopsies was done because of severe autolysis of the liver. There was one subcapsular hematoma, one hepatic arteriovenous fistula, and one liver capsular puncture. Two minor neck hematomas occurred. One death was reported (unrelated to the procedure). QCB needle TJLBx is an effective and relatively safe way to obtain core liver samples.

Adolescent↗
PubMedDate not supplied

[Peripheral facial paralysis and HIV infection. 2 case reports].

Two cases of peripheral facial paralysis in subjects with HIV infection are reported. On the basis of these two cases and data from the literature, the clinical and paraclinical features of this facial nerve lesion are described. The various aetiological hypotheses put forward are discussed, but it is probable that the paralysis results from a direct effect of the virus on the nerve. HIV-associated peripheral facial paralysis may occur irrespective of the number of CD4 lymphocytes and does not seem to have a prognostic significance. However, it appears by preference in stages I, II and III and may then reveal the HIV infection.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Oxyphil cells in a red-tailed hawk (Buteo jamaicensis) with nutritional secondary hyperparathyroidism.

A captive, immature red-tailed hawk (Buteo jamaicensis) was presented with multiple long-bone fractures, a serum calcium of 7.9 mg/dl, and a history of being fed an all-meat diet. Gross and microscopic examinations of the parathyroid glands revealed marked glandular hypertrophy and the presence of interlacing cords and clusters of light chief cells and oxyphil cells in approximately equal numbers. Bone sections showed severe fibrous osteodystrophy. These findings support the observation that the oxyphil cell is a product of continued stimulation, and they suggest that hypocalcemia may be a stimulating factor.

Animals↗
PubMedDate not supplied

Nocardiosis in two Pesquet's parrots (Psittrichas fulgidus).

Nocardiosis is described in two Pesquet's parrots (Psittrichas fulgidus). Granulomatous lesions containing numerous branching, filamentous, acid-fast, gram- and methenamine silver-positive organisms were observed in sections of lung from both parrots, suggesting an oral-respiratory portal of entry. Thyroid follicular hyperplasia and osteoporosis were observed in one parrot, suggesting the presence of an underlying nutritional or metabolic defect.

Animals↗
PubMedDate not supplied

Determining transthoracic impedance, delivered energy, and peak current during defibrillation episodes.

A simplified method has been developed to determine peak current, transthoracic impedance, and delivered energy during a damped sinusoidal defibrillation pulse. The discharge waveform information is generated from sampling the peak discharge current through a current transformer and measuring the voltage stored on the energy storage capacitor. For a given defibrillator circuit a unique relationship exists between the peak discharge current IM and the unknown external impedance Rext presented to the defibrillator by the patient; hence, measurement of IM allows calculation of Rext. A microprocessor-controlled algorithm provides delivered energy information using known internal resistance, capacitance, and inductance parameters. The benefit of this method of delivered energy calculation is that the current and voltage waveforms need not be digitized and then integrated to provide the desired information. This method also keeps defibrillation circuitry ground isolated and simplifies operation through the high electromagnetic fields generated during the discharge. The delivered energy information, along with time, date, and other patient parameters, is documented automatically with an annotation strip-chart recorder.

Adult↗
PubMedDate not supplied

Carcinoembryonic antigen in the assessment of lung cancer.

Carcinoembryonic antigen (CEA) was measured in the plasma by radioimmunoassay in 80 patients who were referred because of an apparently resectable lung cancer. There was no correlation between the initial CEA level and survival in patient whose tumours were found to be inoperable or had metastasized, with only 2 of 37 patients surviving longer than 2 years. Following a curative resection, the median survival for patients with initial CEA greater than 40 micrograms l-1 was 6 months compared to 14 months for those with CEA in the range 20-40 micrograms l-1, while 56 per cent of those with CEA less than 20 micrograms l-1 are still alive at 2 years. This trend was found to be highly significant (P < 0.005). Twenty-five per cent of all patients had an initial CEA greater than 40 micrograms l-1 and this was associated with a poor prognosis, despite complete surgical removal of the primary tumour. Such elevations, if discovered in the preoperative assessment, indicate a need for a thorough search for metastases.

Carcinoembryonic Antigen↗