Biomedical subjects
P Lenner
Publications and source records attributed to P Lenner.
[Malignant lymphoma and exposure to chemical substances, in particular organic solvents, chlorphenol and phenoxyacetates].
Explore the source record for details and available documents.
Staging laparotomy for Hodgkin's disease.
Splenectomy was performed in patients with Hodgkin's disease in a prospective study at the University Hospital of Umeå 1973-1978. Fifty-nine subjects were included and the laparotomy was made as a part of the pre-treatment investigation. The result of the surgical exploration was compared to other investigations, e.g., lymphangiography or cavography. The operation morbidity was 5% (3/59). The clinical stage was changed in 15/58 (26%). Fourteen upstaged and one downstaged. The macroscopical evaluation was poorly correlated to the histological involvement. It is concluded that if the staging procedure is performed by specialized surgeons the morbidity is low. No adverse effects have yet been observed after splenectomy. The staging laparotomy and splenectomy is considered superior to nonsurgical staging procedures from both treatment and cost benefit point of view.
Clinico-pathologic correlation in non-Hodgkin's lymphoma. I. Retrospective analysis using the Lukes and Collins classification.
A retrospective review of 302 patients with non-Hodgkin's lymphoma is presented. The tumors were classified according to a modified Lukes and Collins scheme. Clinico-pathologic correlation was analysed for the subtypes. Certain distinct features were found with respect to age, sex, clinical stage and sites of involvement at admission. Prognostically, two major groups were found with significantly differing survival curves. The pathologic and clinical significance of the modified Lukes and Collins classification is discussed.
Clinico-pathologic correlation in non-Hodgkin's lymphoma. II. Clinical and prognostic significance of nodularity.
A retrospective review of 302 patients with non-Hodgkin's lymphoma is reported. The tumors were classified according to a modified Lukes & Collins scheme and their growth pattern was analysed. Nodular growth was scored in 3 degrees. Nodularity was found to be correlated with certain clinical features and of great relevance for prognosis. The growth pattern was also correlated with cell type, but even within a certain cytologic type, nodular tumors were associated with better survival than diffuse tumors.
Clinico-pathologic correlation in non-Hodgkin's lymphoma. III. Biologic significance of a modified Lukes and Collins classification.
With a modified Lukes & Collins classification of non-Hodgkin's lymphomas applied retrospectively to a patient series the biologic and clinical implications of some microscopic features were analysed. It was found that, based on this classification, proliferation, dissemination and differentiation could be explained in a comprehensible way.
Isozymes of amino acid naphthylamidase in chronic meyloid leukaemia and erythroleukaemia.
Isozymes of amino acid naphthylamidase were investigated in 11 patients with chronic myeloid leukaemia (CML) and 1 patient with erythroleukaemia. Two isozymes were found in all cases (isozymes A and C) which also occur in normal granulocytes. An isozyme with intermediate mobility appeared in all the patients in two main forms (isozymes BF and BS), which both differed from the isozyme B found in normal granulocytes. This may therefore support the diagnosis. In 3 patients a shift occurred between isozymes BF and BS, the possible significance of which is discussed.
Prognostic significance of DNA-analysis by flow cytometry in non-Hodgkin's lymphoma.
DNA analysis by flow cytometry was performed on lymph node cells obtained from 65 untreated patients with non-Hodgkin's lymphoma. According to the Kiel classification 41 cases were of low grade malignancy and 24 cases belonged to the high grade malignancy group. 47 out of 61 evaluable cases were diploid/near-diploid, 12 were aneuploid and 2 cases showed polyploidy. No difference in survival was found between diploid/near-diploid and aneuploid cases. The percentage of S-phase cells was found to be a valuable prognostic parameter. Using a cut point at 4 per cent S-phase cells between low and high S-phase lymphomas a highly significant difference in survival was demonstrated (p = 0.0004). The actuarial survival up to 3 years was about 77 per cent for lymphomas with less than 4 per cent S-phase cells to be compared with 20 per cent for patients with high S-phase (greater than or equal to 4 per cent) lymphomas. Subdivision according to the percentage of S-phase cells seemed to be a better prognostic predictor than morphologic subclassification.
'Aggressive' low grade lymphocytic lymphomas can be identified by flow cytometric S-phase determinations.
Forty-five patients with low grade non-Hodgkin's lymphomas were studied with respect to the fraction of S-phase cells in fresh tumour material by flow cytometric analysis. Patients with stage I lymphomas were treated with radiotherapy, patients with stage II-IV lymphomas with Prednimustine (Sterecyt). Patients with lymphocytic lymphomas of CLL type were only treated if they had symptoms. Median S-phase fraction in the samples was 2.0 per cent. A significantly shorter survival was found for patients with lymphocytic lymphomas with S-phase fractions > 2.0 per cent compared with cases showing lower S-phase fractions. No significant difference in survival was found in the subgroups of immunocytic or follicular and follicular/diffuse centroblastic/centrocytic lymphomas. In a Cox multivariate analysis, in which also age, constitutional symptoms, stage and morphology were included, the fraction of S-phase cells was found to be a statistically significant, prognostic parameter for low grade lymphomas, mainly due to the result in the subgroup of lymphocytic lymphomas.