The effects of varying the levels of cell disruption achieved by high-pressure homogenization upon subsequent centrifugal separation of cell debris have been defined by measuring sedimentation velocity distributions of the cell debris. Using this data together with particle size distributions, a computer-based model of a disk stack centrifuge has been used to predict the efficiency of centrifugal separation. These predictions have been compared with both laboratory scale and pilot plant scale experimental results. A similar sedimentation velocity technique has been used to characterize the properties of the flocs formed by addition of poly(ethylene imine) to a borax-clarified homogenate supernatant. The variations of floc settling properties with respect to polymer concentration are defined.

Biotechnology↗

PubMedDate not supplied

[Not Available].

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Africa↗

PubMedDate not supplied

[Extracorporeal photochemotherapy in therapy-refractory subacute lupus].

BACKGROUND: Extracorporeal photopheresis is a leukapheresis therapy that uses psoralen and ultraviolet A irradiation. We report the case of a woman with a refractory sub acute lupus which dramatically but transitionally responded to extracorporeal photopheresis. CASE REPORT: This women, born in 1960, developed erythematous and squamous patches located on face and neckline, associated with hyperpigmented and atrophic lesions on the arms and shoulders. Investigations confirmed the diagnosis of subacute lupus without systemic disease. All lesions progressed, despite all conventional therapies leading to major aesthetic prejudice. Extracorporeal photopheresis was initiated, and after two months, all lesions, including atrophic and healing lesions had regressed, but laboratory abnormalities did not change. Extracorporeal photopheresis was well tolerated. However, treatment was discontinued nine months later, since the cutaneous lesions relapsed. COMMENTS: Extracorporeal photopheresis could be efficient in the treatment of cutaneous autoimmune diseases through several immunomodulatory mechanisms. Extracorporeal photopheresis is a potent alternative agent in the therapy of refractory dermatological diseases

Adult↗

PubMedDate not supplied

[The association of lupus and Hodgkin's disease. A case history (author's transl)].

The authors report the observation of a young woman 22 years of age having presented the clinical and biological manifestations of disseminated lupus erythematosis, followed more than one year later by the appearance of Hodgkin's disease. Several etiopathological hypothesis concerning this association have been discussed but the experimental work of Schwartz has permitted the finding of a common denominator for these two diseases: a RNA virus, type C.

Adult↗

PubMedDate not supplied

[Attempted clearance by massive plasmapheresis of an anti-HLA antibody in a patient who had received multiple transfusions (author's transl)].

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Antibodies↗

PubMedDate not supplied

Thrombocytopenic purpura and hepatitis C virus infection.

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Acute Disease↗