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Biomedical subjects

P Lefevre

Publications and source records attributed to P Lefevre.

At least 55 records · Page 3Linked to original sources
PubMed1992

Mitogenic activity of quinoline to the rat, mouse, and guinea pig liver: empirical correlations with hepatic carcinogenicity.

Previous studies have shown that the rat liver carcinogen quinoline is essentially nongenotoxic to the rat liver in vivo. Those studies also established it as a potent mitogen to rat liver. The present experiments have established quinoline as a mitogen to the mouse liver, a tissue in which it is also reported to be carcinogenic. In contrast, quinoline is reported to be noncarcinogenic to the guinea pig liver, and the present data establish it to be essentially nonmitogenic to the guinea pig liver. It is concluded that the mitogenicity of quinoline correlates better with its hepatocarcinogenic properties than does its genotoxicity in vivo.

2-Acetylaminofluorene↗
PubMed1991

Thrombotic microangiopathy and the antiphospholipid antibody syndrome.

A 23-year-old woman with the antiphospholipid syndrome developed severe thrombocytopenia (14 x 10(9)/l) and microangiopathic hemolytic anemia after plasma exchange. A relation was suspected between rising anticardiolipin level and development of thrombotic microangiopathy. The mechanism responsible may be interference between anticardiolipin antibody, platelet membrane and endothelial cell.

Adult↗
PubMed1989

[2 cases of pulmonary excision in patients with acquired immunodeficiency syndrome. What is the role of surgery in AIDS?].

The authors report two cases of lung resection in patients with AIDS: left upper lobectomy for diagnosis and treatment of an active, localized lung lesion which proved to be tuberculosis and atypical resection of the right apex and pleurodesis for an infected pneumohydrothorax. The postoperative course was uneventful despite the fragile clinical context. The place of surgical indications for diagnostic purposes is reduced by the good results obtained with endoscopic investigations and limited to failures of these procedures and to pulmonary sarcomatous lesions. The place of therapeutic surgical indications is essentially reserved for pleural complications (pleurodesis, pleurectomy, pleurotomy). Surgery may be unjustified in tracheostomised patients at the stage of respiratory failure. It may have a small but effective role with reduced risk in active, localized lung lesions. The surgery must be performed according to simple and classical by very rigorous rules of protection for the operators and the environment.

Acquired Immunodeficiency Syndrome↗
PubMed1987

[Peculiar indications and results of the use of a blood cell saver apparatus in cardiac surgery].

Results are reported of the use of autotransfusion by means of the blood cell saver in a group of patients at high risk for hemorrhage in Heart Surgery Department. Methods employed are described, and results are discussed: these were encouraging both from the clinical and biological viewpoints. The cost benefits of this procedure are emphasized and technical perspectives outlined with respect to recovery of plasma and platelets.

Adult↗
PubMed1986

Effects of diazepam and midazolam on baroreflex control of heart rate and on sympathetic activity in humans.

The effects of induction of anesthesia with diazepam and midazolam on baroreflex control of heart rate and on plasma levels of catecholamines were investigated in this study. Group 1 subjects (n = 10) received diazepam, 0.4 mg/kg. Group 2 subjects (n = 10) received midazolam, 0.3 mg/kg. Baroreflex function was assessed using a pressor test (phenylephrine). In addition, samples for subsequent determination of plasma norepinephrine and epinephrine levels and plasma diazepam or midazolam concentrations were collected before and 5, 10, and 15 min after intravenous drug administration. The pressor baroreflex slope declined significantly after diazepam or midazolam administration with the maximal changes (-45 and -43%, respectively) observed when plasma diazepam or midazolam concentrations were the highest. Norepinephrine plasma concentrations decreased at each measurement with both drugs. In contrast, epinephrine concentration decreased only after midazolam. The authors conclude that diazepam or midazolam used for induction of anesthesia results in a transient depression of baroreflex function and a sustained decrease of sympathetic tone. This study also indicates that the depression of arterial baroreflex heart rate responses under diazepam or midazolam anesthesia are less pronounced than the depression of baroreflex responses reported by other investigators with potent inhalational anesthetics. However, this disruptive effect of diazepam and midazolam on sympathetic control of circulation might induce a limited ability to compensate for hemodynamic alterations related to hypovolemia.

Adult↗
PubMed1985

[Prevention of postoperative anaerobic bacterial infections in abdominal surgery with metronidazole suppositories].

Metronidazole is widely used for the prevention and treatment of post-operative anaerobic infections. In this study, the prophylactic effectiveness of metronidazole suppositories was tested in patients undergoing abdominal surgery. The suppositories had previously been tested in healthy subjects for drug absorption and tolerance. Patients were divided into three treatment groups: one group received the drug intravenously, another as suppositories and the third one by both routes. Clinical effectiveness was evaluated and plasma metronidazole levels were measured. On the basis of the results obtained, we suggest that a 1 g suppository should be administered 8-hourly over the 20 hours preceding surgery, then 12-hourly if preparation of the digestive tract can be inserted between two administrations. In emergency surgery, 1 suppository must be given at least 1 hour before induction, the 12-hourly, and a 500 mg intravenous infusion at the time of induction.

Abdomen↗
PubMed1983

Effects of droperidol on respiratory drive in humans.

The sensitivity of the respiratory center following a single 0.3 mg X kg-1 iv dose of droperidol was determined in eight healthy volunteers by using carbon dioxide (CO2) rebreathing and mouth occlusion pressure measurements (P0.1). There were no significant differences in the mean slopes of the minute ventilation/partial pressure of CO2 (VE/PCO2) and log P0.1/PCO2 relationships between control measurements and those made 30, 60, 90, 150, and 240 min after droperidol administration. However, individual variations in response were present, one subject showing significant (approximately 50%) depression of respiratory drive.

Adult↗