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Biomedical subjects

P Laugier

Publications and source records attributed to P Laugier.

At least 109 records · Page 6Linked to original sources
PubMed1978

Comparative trial of an antihistamine, mequitazine, and placebo.

Forty patients suffering from a dermatological condition suitable for treatment with an antihistamine were studied in a double-blind randomized trial to compare the effectiveness and tolerance of mequitazine and placebo. Over a period of 2 weeks, patients received either 5 mg mequitazine twice daily or placebo. Where justified, patients were also given concomitant topical treatment but only with a hydrating cream or ichthyol paste. Patients' overall response to treatment was significantly better in the mequitazine group, whether the results were analyzed for all patients or those receiving just the trial drugs without topical treatment. Few side-effects were reported and there was no significant difference between the levels of drowsiness experienced with mequitazine compared with placebo.

Adolescent↗
PubMed1978

[Digestive manifestations of Rendu-Osler's disease (author's transl)].

UNLABELLED: Rendu-Osler disease, hereditary hemorrhagic telangiectasia is a genetic disorder, autosomal dominent. Telangiectasia of the skin, face, trunk, upper and lower extremities are associated with angiomas of the oral and nasopharyngal membranes, lips, tongue and internal organs (intestine tract, liver, spleen, blood, lung, brain). They are source of melena, hematemesis, hematuria, hemoptysis with severe anemia. HISTOLOGY: dilated blood vessels forming cavernous spaces, flattened endothelial cells, no perivascular infiltration, degeneration of the perivascular connective tissue, elastic and muscular fibers missing around the vessels. Therefore hemorrhages are not able to stop spontaneously. Ultrastructural changes : formation of gaps along the thinned-out endothelial lining of dilated vessels, gaps plugged with thrombi. Anormal perivascular collagenous tissue, perivascular smooth muscles elongated and irregular in shape, did not surround the vessels. Liver cirrhosis and blood loss (gastrointestinal hemorrhages sometimes massive) are the only digestive manifestation of the severity. Systematic replacement of iron and blood transfusions are the most helpful forms of treatment.

Gastrointestinal Hemorrhage↗
PubMed1977

[Trial of the culture media Microcult GC for detection of gonococci].

A trial of the culture medium 'Microcult GC' for the detection of gonorrhea in 246 patients confirms its utility. The direct smear of the exudate is still indispensable. The best culture medium is the Thayer-Martin plate. The main advantage of the new medium tested is its simple utilization technique which makes it suitable for the practitioner.

Culture Media↗
PubMed1977

[Essential melanic pigmentation of the mouth and the lips].

Lenticular or linear, buccal or labial, slate-coloured or melanic black spots are noticed in healthy subjects with no racial, hormonal or drug factor. Histological examination shows a pigmentary excess of the basement membrane without anomaly or dystrophy or nevus cells. Ultrastructural study shows a great number of intracyto-plasmic melanosomes, isolated or in group in all the keratinocytes in the third inferior part of the epidermis. No explanation can be given to this melanocyte hyperactivity. An excision can be done without danger for esthetical purpose.

Basement Membrane↗
PubMed1977

[Ultrastructural study of the Dego's disease (report of a new case and literature review) (author's transl)].

An observation of a new case of Degos' disease in a 42 year old woman presenting a merely cutaneous symptomatology, enabled to perform a detailed ultrastructural study of vascular lesions, nerves, infiltrate and perivascular fibroblasts. The episodic clinical evolution with various formation periods of vascular lesions, the frequency of virus-like inclusions in the endothelial cells and fibroblasts, as well as C3 deposits and the presence of intracytoplasmic cylinders in the histiocytes, suggest a common physiopathologic mechanism with the autoimmune diseases. A bibliographic review accompanies the clinico-pathological study.

Adult↗
PubMed1977

[Demonstrations].

Explore the source record for details and available documents.

Adolescent↗
PubMed1976

Experimental keratocanthoma [author's transl].

After topical application of the carcinogen DMBA on the rabbit's ear, tumors will always appear. These are clinically characterized by their important hyperkeratosis. Some of these tumors develop rapidly and disappear completely as do KA. Others do not reach such an important size but do not regress. None of these tumors looked like a malignant tumor and did not show signs of invasiveness nor metastasis. However the histological findings reveal in some cases precancerous and malignant aspects. The number of tumors can be increased by lengthening the application time of the carcinogen, by modifying the mode of application (repeated application and transport medium DMSO) and by irradiation.

9,10-Dimethyl-1,2-benzanthracene↗