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Biomedical subjects

P Lamy

Publications and source records attributed to P Lamy.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Triple biphasic chemotherapy in the treatment of small-cell bronchial cancer].

Forty-three patients with small-cell bronchial carcinoma were treated with sequential combination chemotherapy of the CMC-VAP type alternating every 6 weeks. Toxicity affected mostly blood cells and occurred during induction. The response rate was 60% in circumscribed forms with a median survival of 15 months, and 30% in diffuse forms with a median survival of 6 months. The value of alternating protocols and the place of radiotherapy are discussed in the light of these results.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1980

[Diagnosis of diffuse pneumopathies (author's transl)].

The authors analyze their proceeding in the etiological diagnosis of 40 diffuse pneumopathies in patients admitted to hospital. In 31 cases, diagnosis was made 10 times at the radioclinical stage, 14 times at the endoscopical stage, 6 times at the surgical stage, and once at autopsy. After, they analyze the problems of interpreting the data obtained at each stage, particularly the limited contribution of the X-ray, the necessity of discussing the anatomo-pathological diagnosis (the problem of fibrosis, of sarcoidosis reactions and of pneumoconioses). They insist on the multiplicity of tests to be done on each sample and on the importance of systematic research of K.B. Finally, all the difficulties in diagnosing toxic pneumopathies (whether iatrogenic or not) are recalled.

Adult↗
PubMed1980

[Lung hematomas (author's transl)].

The peculiarity of lung hematomas is due to the association of two types of lesions: vascular ruptures and alveolar ruptures. Six original observations are associated to 68 others published by various authors in a detailed general review. The main characteristics are radiological, with the following stages: 1) diffuse confusion giving a widespread picture of a low density and imprecise outline, 2) constituted hematoma with a dense picture with clear cut outline of late diagnosis, 3) less frequently aero-hydric pictures. Evolution takes place by slow spontaneous resorption which does not always require surgery.

Adult↗
PubMed1980

["Plastic lung". Broncho-pulmonary pathology related to plastics (author's transl)].

Plastics can induce three main groups of respiratory accidents.--Acute and subacute intoxications related to the inhalation of volatil substances from decomposing plastics (mostly during burning and pyrolysis) or on the contrary during synthesis. They are accidental chemical broncho-pneumopathies (acute tracheo-bronchitis and pulmonary edema).--Chronic broncho-pneumopathies following repeated inhalation of dusts or suspension of plastics: pneumoconioses and thesaurismoses leading to pulmonary fibrosis.--Broncho-pneumopathies related to the irritant and sensitizing action of some components of plastics: professional asthma and sensitization pneumopathies. Diagnosis of such diseases therefore imposes a careful study of working conditions. Proof rests on two arguments:--curing by risk eviction;--analysis of the products in order to reveal their toxicity.

Humans↗
PubMed1980

[Emergency fibroscopy (author's transl)].

Emergency bronchial fibroscopy is often asked for by intensive care units. It is usually easy to make examination. The authors tried to evaluate its diagnostic and therapeutical efficiency. They gathered 48 observations of endoscopies performed in the intensive care unit. The diagnostic efficiency is valued at 70% and the therapeutical one at 85%. The main indication is the pulmonary obstruction besides tracheal stenoses, tracheal ruptures, hemoptysis and searching for opportunistic germs.

Bronchoscopy↗
PubMed1980

[Evaluation of diagnostic means in pleural effusions (from two hundred observations) (author's transl)].

From 200 observations, the authors study the results of laboratory examinations and paraclinical testings of the pleura. Neoplastic etiologies represent a 1/3 of all pleurisies. In 20% of cases a definite etiological diagnosis could not be obtained in spite of exploring thoracotomies. The limit of 30 g/l of proteins for the differentiation of mechanical transsudates and inflammatory exsudates was inaccurate. Cytodiagnosis was efficient in 75% of mesotheliomas but the percentage fell to 53 in secondary cancers. For needle biopsy results were respectively of 66% and 57%. Thoracotomy (24 cases) enabled a diagnosis in half the cases where it was performed. Thorascopy seems to bring similar results.

Evaluation Studies as Topic↗
PubMed1980

[Alveolar cancer (author's transl)].

Alveolar cancer is the only true cancer of the lung as opposed to the common bronchial cancer. The authors defend this thesis by contesting the excessive usage of the expression bronchiolo-alveolar cancer and by supporting it with 12 original observations together with the literature review. The anatomo-pathological data are reported and discussed in order to analyze the reliability of the observations; diagnosis can vary according to the methods used in comparing the bronchial cytology and the examination of the operation tissue samples; the evolutive back search of observations revealed that out of 9 operated cases with localized involvement, 5 patients were still alive 2 years later. Complementary examinations by scintigraphy with labelled bleomycin were disappointing; this test performed 4 times was only once positive. Data from electron-microscopy and tissue culture seem to point towards a histogenesis from type II pneumocyte.

Adult↗
PubMed1979

[Chemotherapy of non-microcellular disseminated bronchial cancer (author's transl)].

Fifty-one patients suffering from non-microcellular bronchial cancer with metastasis were divided at random into two groups: 33 patients received BACFON polychemotherapy, 18 patients did not receive chemotherapy. There was no global significant difference between the two groups (total mean survival time : 22 weeks with good therapy and 18 without), but a significant difference could be observed if there was an early response (M.S.T. : 38 weeks) compared to no response (M.S.T. : 15 weeks). Similar results were obtained when radiotherapy was associated (M.S.T. : 34 weeks) compared to chemotherapy without radiotherapy (M.S.T. : 22 weeks).

Adenocarcinoma↗