Biomedical subjects
Publications and source records attributed to P Kind.
A 24-year-old female patient was treated for many years for "verrucae vulgares". Signs of porokeratosis were found by microscopy. Her medical history, the distribution of the hyperkeratotic-verruciform lesions and the characteristic histology features permitted the diagnosis to be made of porokeratosis plantaris, palmaris et disseminata.
Cryostat tissue sections from skin lesions of 16 patients suffering from chronic stationary psoriasis vulgaris were assayed for the presence of distinct T-cell subpopulations with monoclonal antibodies. Using two pan-T surface markers (M-T 4-11 and Lyt 3) the total number of infiltrating T-cells was measured. This cell population was further dissected into Leu 3a (helper/inducer) and M-T 8-11 (cytotoxic/suppressor) positive subsets. Percentages of T-cell subpopulations were within the ranges found in healthy peripheral blood and were thus regarded as normal.
Primary cutaneous leiomyosarcomas are rare mesenchymal skin tumors with relatively good prognosis and low risk of metastasis if there is no subcutaneous involvement. A 48-year-old patient with a primary cutaneous leiomyosarcoma of ten years duration is described. Therapy and differential diagnosis are discussed.
In a retrospective study of 28 successive admissions for in-patient psychotherapy, the following characteristics have been identified as predictors of favourable outcome: a diagnosis of neurotic psychopathology; superior intelligence; considerable depression; and minimal previous out-patient treatment. Two alternative sets of decision rules are presented which might be used as a guide in deciding whether to admit patients. More rigorous selection criteria are suggested in the common situation where the demand for treatment greatly exceeds the supply of facilities, but such criteria would result in the exclusion of a small proportion of borderline patients who might respond to in-patient psychotherapy and might otherwise prove untreatable.
The measurement properties of a health status indicator are closely related to the scaling model on which it is based. The Thurstone and Bradley-Terry models are applied to paired comparisons data which had been used to scale the sleep category of the Nottingham Health Profile. The data in their original form are shown to be inadequately represented by either model. Weaknesses in the data are identified and the two scaling models are applied to the amended data. The results of applying two sets of scale values are compared.
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A difficult task in designing indices of health and measures of health output is deriving a scale of valuations of a set of defined states of health or illness. A scale derived by structured interview of 70 subjects and tested on a further 50 subjects is described. The method aims for a ratio scale and the extent to which this has actually been achieved is discussed. Scale values appear to be independent of the sex, age, socio-economic group, religious belief and past medical history of the subject, but have some association with current experience of illness. There is agreement between scale values obtained from medical nurses and patients and agreement between the different values obtained from psychiatric nurses and patients.
The roles of T and B cells in the immune response to influenza virus were studied by using mice deficient in either T cells (athymic nude) or immunoglobulin production (CBA/N). The serological responses of these mice to either whole or disrupted A/Aichi/2/68 influenza virus vaccines were examined, and the protective effect of these inoculations was tested by challenge infection with mouse-adapted A/Aichi/2/68 influenza virus. In contrast to normal mice, neither strain of immunodeficient mouse produced detectable serum antibody after inoculation with either type of vaccine. CBA/N mice immunized with intact virus vaccine were protected, however, against subsequent lethal challenge. CBA/N mice inoculated with disrupted virus vaccine and nude mice inoculated with either disrupted or whole virus vaccine were not protected against viral challenge. Evidence of immunological memory was observed in CBA/N and nude mice that had survived live virus challenge after immunization with inactivated vaccine.
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