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P Kind

Publications and source records attributed to P Kind.

At least 127 records · Page 7Linked to original sources
PubMed1990

[Lupus erythematosus].

Our paper summarizes the clinical and photobiological studies on lupus erythematosus (LE) performed at the Department of Dermatology, University of Düsseldorf, during the last 5 years. A total of 190 LE cases were examined and classified according to the various cutaneous forms of LE. Except for lupus erythematosus tumidus (LET), we found a female predominance in all other groups. Discoid lupus erythematosus (DLE) is the most common variant of cutaneous LE. Subacute cutaneous lupus erythematosus (SCLE), a less common type, is characterized by the presence of Ro-antibodies, although this marker does not correlate with the degree of photosensitivity. The rare LET is an extremely photosensitive form of LE, which clearly prefers the male sex.

Adolescent↗
PubMed1989

[Acral lentiginous malignant melanoma].

Whether acral lentiginous malignant melanoma (ALM) has to be regarded as an independent entity of malignant melanoma is still controversial. But sure, there are some clinical and histological characteristics regarding melanoma of acral location which support a separate consideration of this disease. Our paper will discuss the peculiarities of ALM.

Aged↗
PubMed1989

[Livido racemosa in detection of anti-phospholipid antibodies].

Livedo reticularis and antiphospholipid antibodies have previously been found to be associated with a subgroup of patients with systemic lupus erythematosus. We present a case of livedo reticularis accompanied by antiphospholipid antibodies, in which no other signs of any systemic or cutaneous disease could be detected.

Adult↗
PubMed1988

[Bullous systemic lupus erythematosus].

Bullous lupus erythematosus (BLE) is an uncommon variant of systemic lupus erythematosus (SLE). We present a 23-year-old man with SLE, who developed a bullous eruption associated with a flare of the systemic disease. Differential diagnosis and problems of diagnosis are discussed.

Adult↗
PubMed1988

Metallothionein induction in a human B cell line by stimulated immune cell products.

Metallothionein (MT) is a protein inducible by heavy metals, various chemicals, immunomodulatory substances, and interleukins. We have asked the question whether immunostimulatory substances, such as lipopolysaccharide (LPS) or Concanavalin A (Con A), or supernatants obtained from human peripheral mononuclear cells (hPMC), which had been stimulated with LPS or Con A, are able to induce increased MT concentrations in cells of the immune system. For this purpose, the effects of LPS and Con A, and of supernatants obtained from immune cells stimulated by them were studied using the human IgM-secreting B cell line RPMI 1788. Supernatants obtained from hPMC that were stimulated by LPS or Con A increased the MT concentration in RPMI 1788 cells. However, LPS or Con A failed directly to increase MT concentrations in RPMI 1788 cells, whereas they increased MT concentrations in hPMC. Our data support the hypothesis that MT is probably not only important for metal homeostasis and protection against environmental hazards but also during immunostimulation.

B-Lymphocytes↗
PubMed1987

[Clinical aspects and differential diagnosis of cutaneous lupus erythematosus].

On the basis of LE cases treated at the Department of Dermatology, Düsseldorf University, during the last few years, we present the various forms of cutaneous lupus erythematosus (CLE). 72% of the patients showed discoid lupus erythematosus (DLE), whereas disseminated discoid LE (DDLE) and lupus panniculitis were found in 3% each. Lupus erythematosus tumidus (LET), as well, must be regarded as exceptional. Subacute cutaneous LE (SCLE) and systemic LE (SLE) showed nearly similar frequency (10 and 12%, resp.). Bullous LE is also very rare and must be considered a variant of SLE. The various forms of cutaneous LE can be differentiated according to clinical presentation and histopathology. Direct immunofluorescence, in contrast, has but limited diagnostic value, except with lesions on the scalp. Exact classification of cutaneous LE is the more essential, as it implies considerable therapeutic and prognostic consequences for the patient.

Diagnosis, Differential↗
PubMed1987

The Nottingham health profile: a useful tool for epidemiologists?

The Nottingham health profile has been portrayed as a multipurpose measure of health status, capable of being used in population surveys and in evaluation of medical interventions. This paper examines basic operating characteristics of the profile, using data collected in a large survey of the community. Examination of the response pattern suggests that the NHP is not effective in discriminating health statuses as the modal response is zero. If it is to be used as a screening tool then there are considerable redundancies so that two or three items are sufficient; and for a diagnostic purpose, the existence of substantial covariation between items makes interpretation difficult. There is a need for an instrument fulfilling one or all of these purposes, but we need to know the operating characteristics of any instrument in detail before applying it. These results demonstrate that the methodological base of the NHP has yet to be established.

Epidemiologic Methods↗
PubMed1987

The relationship of serum alpha-interferon and ultrastructural markers in HIV-seropositive individuals.

Two inclusions of the endoplasmic reticulum, tubuloreticular inclusion (TRI) and cylindrical confronting cisternae (CCC), are common to lymphocytes from individuals with AIDS and AIDS-related conditions. Both inclusions can be induced in vitro with alpha-interferon (IFN). IFN may also be elevated in both populations. Circulating lymphocytes containing TRI are seen prior to the appearance of serum IFN. CCC appear in circulating lymphocytes after TRI, and both regularly antedate the diagnosis of AIDS. As in systemic lupus erythematosus (SLE), it can be hypothesized that lymphocytes exposed locally to IFN acquire TRI and then appear in the peripheral blood to be followed subsequently by IFN. The data strongly suggest that the appearance of these markers may predict the progression to AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1987

[Nuclear antibodies as serologic markers in progressive systemic scleroderma].

In all, 36 patients with progressive systemic sclerosis (29 women, 7 men) were studied clinically and immunologically; 15 patients had acrosclerosis (type I) and 21, sclerosis extending beyond the wrist (type II). The sera of all patients were evaluated for ANA (HEp-2-cells), Scl-70, centromere and other ENA antibodies. The centromere antigen was characterized by immunoblotting. All patients had high-titer ANA antibodies (100%); 36% of patients had the Scl-70 antibody (a marker antibody for PSS); and in 22% of our patients a centromere antibody was detected. In all cases the anti-centromere sera reacted with a 19.5-kd polypeptide and in 2 cases they reacted with 23- and 25.5-kd proteins in addition. In patients with centromere antibodies there was increased organ involvement (heart, lung, kidney) compared with patients who had anti-Scl-70 or other nuclear antibodies.

Antibodies, Antinuclear↗
PubMed1987

[Penicillamine-induced pemphigus].

D-Penicillamine is effective in the treatment of Wilson's disease, cystinuria and rheumatoid arthritis. However, it may have adverse side-effects by inducing a spectrum of diseases such as myasthenia gravis, lupus-like disease, IgA deficiency and pemphigus vulgaris. A case of D-penicillamine-induced pemphigus is presented. The clinical aspects, pathogenesis, immunology and therapy of D-penicillamine-induced diseases are discussed.

Arthritis, Rheumatoid↗
PubMed1986

Circulating T- and B-cell abnormalities in cutaneous lupus erythematosus.

Seven patients with subacute cutaneous lupus erythematosus (SCLE), 11 patients with discoid lupus erythematosus (DLE), and 17 age-, sex-, and race-matched controls were examined for the number of circulating peripheral blood T and B cells, immunoglobulin (Ig) synthesizing cells, and Ig secreting cells. A significant alteration in T-cell subsets was detected only in SCLE patients who manifested a decreased number of OKT8 cells. Circulating B cells were significantly increased only in the SCLE patients. The percentage of Ig synthesizing and secreting cells was significantly increased in both the DLE and the SCLE groups. The somewhat unexpected increase in Ig synthesizing and secreting cells in the DLE patients could not be accounted for by antimalarial treatment or the concurrence of the HLA-DR3 phenotype. There was, however, a weak but significant correlation between the degree of B-cell activation in the DLE patients and the number of American Rheumatism Association criteria for the classification of systemic lupus erythematosus (SLE) possessed by these patients. These data demonstrate that abnormalities in B-cell function similar to those seen in SLE can also be found in a group of lupus erythematosus patients whose clinical disease expression is limited predominantly to the skin.

B-Lymphocytes↗