[Prenatal diagnosis and its significance for internal medicine].
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Biomedical subjects
Publications and source records attributed to P Kaiser.
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We report a 10-year-old male patients with the predominant karyotype 46,XX. In only one cell of the testis culture a metaphase with 47,XX+G was found. The theories of etiology of XX-males and the reported cases of XX/XXY-mosaics in the literature were discussed.
A 31-year-old female patient with short stature, signs of gonadal dysgenesis, and slight Turner signs is described with a mosaic 45,XO/46,XX del (X) (qter leads to p11) determined with trypsin Giemsa-banding and C-staining. BUdR incorporation indicated the deleted X to be late replicating.
A 27-year-old patient of short stature with primary amenorrhea and other slight Turner signs showed a 46,XX,del(X) (qter leads to p11:) karyotype, identified by a combination of fluorescence and giemsa-banding technique. By BUdR incorporation the deleted X chromosome was shown to be the late replicating one.
In patients with myocardial infarction (MI) the presence or absence of lesions in vessels other than the one which perfuses the infarcted area, has implications regarding coronary bypass surgery, long term anticoagulant therapy, work capacity and prognosis. We investigated whether involvement of a 2nd or 3rd vessels as demonstrated by coronary angiography can be predicted on the basis of angina pectoris and/or ischemic ST-segment depression during exercise. Inferior myocardial infarction (IMI, n = 146) Severe lesions (greater than or equal to 75%) of a 2nd or 3rd vessel were found in 61.7% of patients with IMI, who developed angina pectoris and ischemic ST-segment depression, in 18.6% of patients with ST-segment depression only, in 9.1% of patients with angina pectoris only and in 3.4% with neither angina pectoris nor ST-segment depression. Anteroseptal infarction (ASI, n = 116) Severe lesions (greater than or equal to 75%) of a 2nd or 3rd vessel were found in 30.2% of patients with ASI, who developed Angina pectoris and ischemic ST-segment depression; in 26.6% of patients with ST-segment depression only, in 20.0% of patients with angina pectoris only and in 3.0% of the patients with neither angina pectoris nor ST-segment depression. The clinical implications of the results are discussed.
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