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Biomedical subjects

P Kaiser

Publications and source records attributed to P Kaiser.

At least 109 records · Page 6Linked to original sources
PubMed1983

Effects of beta-adrenergic blockade on O2 uptake during submaximal and maximal exercise.

Changes in cardiorespiratory variables and perceived rate of exertion (RPE) were studied in 13 trained men performing cycling exercise before and after beta-adrenergic blockade. Propranolol (Inderal, 80 mg) was administered orally 2 h prior to standardized maximal and submaximal exercises. Muscle biopsies were obtained from vastus lateralis at rest for subsequent histochemical analyses of muscle fiber type distribution and capillary supply. During submaximal exercise O2 consumption decreased from 2.76 to 2.59 l . min-1 following blockade (P less than 0.01), whereas heart rate decreased from 157 to 113 beats . min-1 (P less than 0.001). Maximal O2 uptake was lowered from 3.79 to 3.26 l . min-1 (P less than 0.001) and maximal heart rate was reduced from 192 to 142 beats . min-1 (P less than 0.001) as a result of the blockade. Pulmonary ventilation was unaltered in both exercise conditions. "Local" RPE was higher (P less than 0.001) than "central" RPE after beta-blockade in both submaximal and maximal exercise. During normal condition this difference did not appear. Changes in both local and central RPE during submaximal exercise were positively correlated to changes in O2 uptake. Individual variations in the metabolic profile of the exercising muscle had no influence on beta-blockade-induced changes in O2 uptake. It is concluded that blockade of beta-adrenergic receptors reduces O2 consumption during submaximal (approximately 73% maximal O2 uptake) and maximal exercise in habitually trained men.

Adrenergic beta-Antagonists↗
PubMed1983

A category-ratio perceived exertion scale: relationship to blood and muscle lactates and heart rate.

The purpose of this investigation was to study the relationship between perceptual ratings from Borg's new category-ratio scale and some physiological variables during exercise. To accomplish this, scale ratings were related to blood and muscle lactate accumulation and heart rates during a progressive, maximal exercise test on the cycle ergometer. Ten physically active males were utilized as subjects; lactate data were recorded on only 7 of the 10 subjects. Three ratings of perceived exertion were made at each stage of the exercise test: leg effort (LE), cardiorespiratory effort (CE), and leg pain (LP). All ratings showed a positively accelerating increase with exercise intensity as did both blood and muscle lactate, while heart rate increased linearly. The exponents of the power functions describing the perceptual variation ranged from 1.63-1.67 compared to 2.2 for blood lactate and 2.7 for muscle lactate. Polynomial analysis revealed a similar quadratic trend for both perceptual and blood lactate data; however, muscle lactate demonstrated a cubic trend. No significant differences were found between CE and LE at 100, 200, and 300 W (P greater than 0.05). Subjects with the highest percentage of slow-twitch muscle fibers (mean ST%=51.14) rated LE and CE significantly lower ( mean of all power outputs, 0-300 W) than those with the lowest ST% (mean=34.52). It is concluded that the ratings from the category-ratio scale correspond very well with glycogenolytic metabolism leading to lactate accumulation during exercise.

Adolescent↗
PubMed1982

Running performance as a function of the dose-response relationship to beta-adrenoceptor blockade.

There is a discrepancy between the effect of beta-blockade on exercise heart rate and the effect on exercise capacity. Thus, it was of interest to study the dose-response relationship between an unselective (propranolol) and a beta 1-selective (atenolol) blocker and endurance exercise performance. Nine habitually active males ran their own jogging route 10 times and the distances of the routes ranged between 4000 and 10000 m. Placebo (twice), 25, 50, 75, and 100 mg of atenolol and 40, 80, 120, and 160 mg of propranolol were administered orally with a double-blind, crossover procedure. After each experiment, running time and rate of perceived exertion (RPE) were registered. Small drug doses markedly affected exercise heart rates yet such doses minimally affected running performance when on the beta 1 selective blocker. With 160 mg propranolol, a greater exercise impairment occurred than with 100 mg atenolol (P less than 0.05). RPE data suggested that drug treatment induced an increased subjective feeling of fatigue in addition to the impaired performance, and these changes were positively related (r = 0.66, P less than 0.05). Impairment of exercise performance during acute beta-blockade is evidently not related solely to the effect on heart rate. The nature of other drug effects is presently unclear although there is evidence that the metabolic profile of the muscle is implicated.

Adrenergic beta-Antagonists↗
PubMed1982

Lactate in blood, mixed skeletal muscle, and FT or ST fibres during cycle exercise in man.

The relationship between muscle and blood lactate levels during progressively step-wise incrementing cycle exercise has been investigated in 10 male subjects. Steps between power outputs during exercise were 50 W and each stage, from loadless pedalling until voluntary exhaustion, lasted 4 min. Blood samples and biopsies (m. vastus lateralis) were taken for lactate determination at each power output beginning with the exercise intensity perceived by the subject as being "rather moderate". The ratio muscle:blood lactate was greater than one at all power outputs and increased most markedly at the power output closest to that eliciting 4 mmol x 1(-1) blood lactate (WOBLA). At WOBLA, blood lactate was positively correlated to muscle lactate concentrations which covaried widely among subjects (mean 8.3, range 4.5-14.4 mmol x kg-1 wet weight). Muscles fibres from the WOBLA biopsy in 6 subjects were dissected out and identified as fast twitch (FT) or slow twitch (ST). No significant difference in lactate concentration was observed between pools of FT or ST fibres.

Adolescent↗
PubMed1982

Changes in muscle metabolites in females with 30-s exhaustive exercise.

The purpose of this study was to quantify the changes in selected intramuscular metabolites associated with non-oxidative energy metabolism after performance of the Wingate Test (WT), a widely used, exhaustive, 30-s cycle test of short-time muscular power. Muscle biopsies were taken from the m. vastus lateralis of nine female physical education students at rest and immediately after performance of the WT. The concentrations of adenosine triphosphate (ATP), creatine phosphate (CP), lactate, and glycogen were determined. The ATP decreased from 20.9 to 13.8; CP decreased from 62.7 to 25.1; lactate increased from 9.0 to 60.5; and glycogen decreased from 360 to 278 (all concentrations are mmol X kg-1 dry muscle). The absolute changes in CP and lactate were not as large as those reported in other exercise studies. Based on the metabolite changes, it was concluded that the WT is a satisfactory test of the maximal muscular power that can be generated from non-oxidative metabolism, but that the 30-s duration of the test probably does not tax the maximal capacity of such energy metabolism.

Adenosine Triphosphate↗
PubMed1981

Relevance of muscle fibre type to fatigue in short intense and prolonged exercise in man.

It has been suggested that the histological and histochemical features of human muscle are important in determining performance capacity. The relationship between muscle fibre types (Type I, slow twitch fibres; Type II, fast twitch fibres) and performance on standardized tests has been studied in subjects accustomed to physical exercise, and related to their patterns of lactate metabolism, expressed as the onset of blood lactate accumulation (OBLA). This variable was found to be the best predictor of endurance capacity of the variables studied. It is suggested that in healthy male subjects muscle lactate is crucial in short, intense forms of exercise (the higher the lactate formation, the better the performance) and also in prolonged, "endurance' forms of exercise (the later the onset of lactate formation, the higher the sustainable exercise intensity). In subjects with a high proportion of fast twitch fibres, more lactate will be formed at the same exercise intensity. This is advantageous for short intense exercise but impairs endurance performance. The deleterious effects induced by glycogen depletion were studied and found to be most pronounced in subjects rich in fast twitch (glycogen-dependent) fibres. Indications were also obtained that muscular performance is regulated in different ways in males and females. In women an inverse relationship was found between fast twitch fibres and muscle power, and between fatigue and lactate concentration, whereas direct relations were found in men.

Biopsy↗
PubMed1981

Muscle strength and fatigue after selective glycogen depletion in human skeletal muscle fibers.

Two groups of male subjects were studied to examine the effects of different exercise protocols on performance of an isokinetic, short-time strength test, the performance of which is related to fast twitch (FT) muscle fiber recruitment. The laboratory group (LG) (n = 10) cycled (30 min, 70% VO2 max), ran (75 min), and performed repeated bouts of "sprint" cycling and rapid, maximal contractions of the quadriceps. The marathon group (MG) (n = 7) participated in and completed Stockholm's Marathon 1979. A strength test was performed before and within 1-2 h after completion of the group exercise protocol. The m. vastus lateralis was biopsied and muscle fibers classified as slow twitch (ST) or FT. After periodic acid-Schiff staining fibers were qualitatively classified as to glycogen content. In LG significant glycogen depletion occurred in both fiber types and in MG predominantly ST fibers were exhausted of glycogen after the exercise protocol. The glycogen exhaustion from both fiber types in LG was associated with impaired maximal muscular strength produced during a single dynamic contraction, as well as with reduced muscle fatigue patterns. When glycogen exhaustion was induced in ST muscle fibers only in the MG, no impairment was observed for maximal muscular strength but fatigue during 50 consecutive contractions was significantly increased.

Adult↗
PubMed1981

Effects of beta-adrenergic blockade on endurance and short-time performance in respect to individual muscle fiber composition.

Nine physically active males were studied three times with four different exercise tests after administration of placebo, 0.1 g atenolol, or 0.08 g propranolol in random order. The test modals were: bicycle ergometer exercise at 50% of VO2max, peak torque during knee extension, the Wingate muscle power test, and 2000 m track running. Muscle fiber composition had previously been determined. In subjects with a high percentage of slow-twitch fibers the beta-blockers caused a more marked impairment in the exercising muscles. This effect was more pronounced with the unselective beta-blocker propranolol than with atenolol. One interpretation of our findings is that peripheral sympathetic beta 2-receptors in skeletal muscles may contribute to regulating muscle metabolism.

Adrenergic beta-Antagonists↗
PubMed1981

Relationships between leg muscle fiber type distribution and leg exercise performance.

The object of the present experiments was to study the impact of muscle fiber type composition on "aerobic" and "anaerobic" performance capacities. Muscle fiber type composition was determined on biopsies from the m. vastus lateralis of 29 healthy males, consisting of sedentary subjects, physical education students, and short- and long-distance runners. The subjects performed: (a) a 30-s all-out ride on a cycle ergometer; b) a short-term (60 s), isokinetic, one-leg exercise test, (c) a 40-m sprint run; d) a 300 m run; and (e) a 2000-m run. Correlations between muscle fiber composition, expressed as % fast twitch (FT) fibers on one hand, and peak power, maximal peak torque, power decrease, and peak torque decrease in the laboratory tests were significant (P less than O.001) for the trained subjects but not for the sedentaries. Average speed during the 40-m sprint and the 2000-m run was positively (P less than 0.001) and negatively (P less than 0.001) related, respectively, to % FT in the trained subjects whereas no such correlations were present for sedentaries. It is suggested that fiber type composition in trained males is one factor contributing to ability to perform short-term as well as endurance exercise. This statement may not be true for the general population.

Adolescent↗
PubMed1980

[Rare diseases of the thyroid gland in children].

5 cases of children with rare diseases of the thyroid gland are reported. The good prognosis of malignant tumours in childhood is mentioned. The operative management suitable for the different diseases is discussed.

Adenocarcinoma↗