Biomedical subjects
P Julien
Publications and source records attributed to P Julien.
[Not Available].
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Effects of pacing-induced ischemia on myocardial free fatty acid extractions.
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A comparison of fatty acid patterns of arterial plasma, pericardial fluid and cardiac lymph in dog.
The fatty acid composition of cardiac lymph and pericardial fluid in anesthetized open-chest dogs, was analysed and compared with that of arterial plasma. The fatty acid content of triglyceride (TG) and total fatty acid fractions of pericardial fluid and cardiac lymph was significantly lower than that of plasma. On the other hand, free fatty acid (FFA) concentrations of pericardial fluid, cardiac lymph and plasma were not significantly different. The FFA fraction of cardiac lymph contained relatively more stearic acid and less oleic acid whereas, in plasma, the FFA fraction contains less myristic acid. The data are consistent with the hypothesis that endothelial permeability is a limiting factor for the transvascular exchanges of large molecules such as TG and that the FFA distribution in intersititial spaces may have been modified by the contribution of fatty acids from endogenous cardiac reserves or from the hydrolysis of plasma TG.
Role of cardiac lymph and interstitial fluid in lipid metabolism of canine heart.
To determine whether cardiac interstitial spaces participate in cardiac fatty acid pool, the relationship between cardiac lymph and arterial plasma free palmitate and triglycerides was studied in anesthetized dogs [14C]Sucrose, infused at a constant rate in a femoral vein, appeared in the lymph at 90% of its arterial concentration within 60 min. On the other hand, when [1-14C]palmitate was infused at the same rate and at the same site, the ratio of lymph to arterial plasma 14C-labelled free fatty acids (FFA) was only 21% at 60 min and 25% at 120 min, even though the concentrations of endogenous FFA in lymph and arterial plasma were the same. The ratio reached 90% only 24 h after a bolus injection of [3H]palmitate. [1-14C]Palmitate in the lymph triglyceride fraction was only 8% of that in plasma. Although the lymph composition may be influenced by the metabolism of heart muscle, cardiac adipose tissue, and serum lipoproteins, these results indicate the presence of a pool of myocardial fatty acids which may be partly located in the interstitial spaces.
Medicine and pharmacy in French political prints--the Franco-Prussian war and the Commune.
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Dose-effect studies on estrogen induced mammary cancers in mice.
Castrated male (C3H X RIII) F1 mice were treated with graded doses of estradiol-17-beta and estrone in a life-span experiment. Estradiol-17-beta incorporated into paraffin pellets was implanted under the skin for continuous resorption. These pellets contained 1 microgram, 2.5 microgram, 5 microgram, 10 microgram or 100 microgram of hormone. Estron was given orally, mixed with the food at 3 daily dosages: 0.06 microgram, 0.6 microgram and 6 microgram. Although the smallest dosages of both hormones induced vaginal estrus in castrated females, they did not produce mammary tumors. The mammary tumor incidence reached progressively almost 100% in response to the increase of the hormonal dosages. The absence of effect of low doses of estrogen in mice is compared with the absence of an excess of breast cancers among women using oral contraceptives.