Biomedical subjects
P Julien
Publications and source records attributed to P Julien.
The effects of hypothyroidism, age, and nutrition on LDL catabolism in the rat.
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Composition and metabolism of very low density lipoproteins in dog cardiac lymph.
In the present study, very low density lipoprotein (VLDL, d less than 1.006) in cardiac lymph was characterized to determine its role as a metabolic substrate in the interstitial compartment. A major efferent cardiac lymph trunk was cannulated in fasting (18 h) dogs (20-27 kg). Three to five millilitres of lymph were collected over 3-4 h at 4 degrees C. Cardiac lymph VLDL concentration was 1.7 +/- 0.7 mg protein . 100 mL-1 compared with 1.8 +/- 0.8 mg protein . 100 mL-1 in plasma. The VLDL triglyceride concentration in lymph was 1.0 +/- 0.3 mg triglyceride . 100 mL-1 with triglyceride/protein ratio of 0.9 compared with plasma VLDL triglyceride of 5.0 +/- 1.6 mg . 100 mL-1 with a triglyceride/protein ratio of 5.5. Electron microscopy of VLDL revealed globular particles with a mean diameter of 388 A in lymph and 661 A in plasma. Thus, cardiac lymph VLDL are smaller and contain less triglyceride per particle than plasma VLDL. Following i.v. administration of human 125I-labelled low density lipoprotein ([125I]LDL, d 1.025-1.045), cardiac lymph/plasma LDL specific activity ratio was 0.52 +/- 0.15 (n = 3) and 0.55 +/- 0.15 (n = 4)) at 3 and 27 h, respectively. The fact that the specific activity ratio did not reach 1 at plateau suggests continuous addition of unlabelled LDL in the cardiac interstitium, presumably from VLDL precursors. These findings demonstrate that on a protein basis the concentration of VLDL in cardiac lymph equals that of plasma, and also suggests that VLDL degradation and LDL production occur in the cardiac interstitial space.
Lipoprotein composition and transport in the pig and dog cardiac lymphatic system.
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[Not Available].
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