Search PubMed⌕ Search

Biomedical subjects

P J Cook

Publications and source records attributed to P J Cook.

At least 91 records · Page 5Linked to original sources
PubMed1975

Improved estimate of the Gm-Pi linkage.

The Gm-Piota linkage group is firmly established. A heterogeneity of recombination fraction amongst males of different Piota types has now become very likely. The major differences seem to be between the Piota (z) and other alleles of the Pi system. A chromosomal deletion, inversion or a regulatory (rec) locus in linkage disequilibrium with the Piota locus offer possible explanations.

Alleles↗
PubMed1975

The genetics of alpha1-antitrypsin: a family study in England and Scotland.

The results of Pi typing 5237 unrelated Caucasians are presented, together with the phenotypes of 2203 children from 1156 families. The estimate of the gene frequencies in the United Kingdom are Pi-M equal 0-9303, Pi-S equal 0-050, Pi-Z equal 0-0141, Pi-minus equal 0-0015, Pi-V equal 0-0004. Evidence for three new alleles, Pi-W2, Pi-Y2 is presented. The results of twin studies and quantitative studies are discussed.

Black or African American↗
PubMed1975

Linkage data on red cell acid phosphatase from family studies.

An analysis of the linkage relationships of red cell acid phosphatase (ACP1) with 36 other loci is presented. Close linkage is excluded for many loci. The hint of loose linkage with MNSs is not statistically significant, nor is it apparently consistent with the assignment of ACP1 and and MNSs to different arms of chromosome 2.

Acid Phosphatase↗