Search PubMed⌕ Search

Biomedical subjects

P J Cook

Publications and source records attributed to P J Cook.

At least 73 records · Page 4Linked to original sources
PubMed1980

Assignment of the human locus determining phosphoglycolate phosphatase (PGP) to chromosome 16.

The segregation of human phosphoglycolate phosphatase has been studied in 52 independent human-rodent hybrids and 69 subclones. The results suggest that human PGP is on chromosome 16. Family data suggest that PGP is not close to 16qh or alpha Hp. The most likely regional assignment for PGP would appear to be 16p13 or 16p12, but a site on 16q cannot be entirely excluded. New data on 16qh and alpha Hp suggest that the male recombination fraction between these loci is about 0.2.

Alleles↗
PubMed1980

Carbenoxolone (duogastrone) and cimetidine in the treatment of duodenal ulcer--a therapeutic trial.

A double-blind, double-dummy trial to compare carbenoxolone (Duogastrone) with cimetidine has been carried out in patients with duodenal ulcer. Sixty patients completed the six week trial period, 31 patients were treated with carbenoxolone and 29 with cimetidine. Both groups were comparable with respect to age, sex, smoking habits and alcohol intake. There were no significant differences between groups during the trial period with respect to symptomatic relief and antacid consumption. Endoscopy after six weeks of therapy showed healing in 61% of patients receiving carbenoxolone and 72% in those receiving cimetidine, a difference which is not significant. No serious side-effects occurred with either drug.

Adult↗
PubMed1978

Pre-medication for endoscopy. A trial of atropine, pentazocine or pethidine as a supplement to diazepam.

The effects of giving atropine, pentazocine or pethidine, 30--45 minutes before intravenous diazepam have been assessed and compared with a control group given diazepam alone in a double-blind controlled trial of pre-medication for upper gastrointestinal endoscopy involving 143 patients and 6 endoscopists. Atropine or pentazocine increased the success rate of the procedure (p 0.007) but gave no other definite benefit. Pethidine improved the degree of sedation (p 0.01) and the success rate (p 0.007); the combination of pethidine given before diazepam ranked first of all the four treatment regimes. The patients' opinion of the procedure correlated with the duration of endoscopy and the experience of the endoscopist.

Adult↗
PubMed1977

Family studies with the chromosome 9 markers ABO, AK1, ACONs and 9qh.

We have failed to measure the recombination fraction between 9qh and the ABO:AK1 linkage group. Since the total male map distance along chromosome 9 is likely to be at least 120 cM, calculated from male chiasmata counts (Hultén, 1974) they may well not be within measurable distance of each other. ACONs does not lie between ABO and AK1, but there is so little information on this marker from family studies that it could lie almost anywhere else on chromosome 9 and might be within measurable distance of 9qh. The map of chromosome 9 based on studies on families with normal karyotypes is summarized in Fig. 1. We hope to improve this map in a subsequent paper based on observations on families with abnormal karyotypes.

ABO Blood-Group System↗
PubMed1977

Linkage studies with C6.

The common structural variants of C6 have been used to study the linkage relations of the locus in human pedigrees. Linkage between C6 and RH, Fy, ACP1, MNSS, Jk, HLA, ABO, ESD, Hp, ADA, GPT, Gc, Pi, Gm and Km has been excluded at recombination fractions at least as great as 0-1 in the male.

Alleles↗