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Biomedical subjects

P Huber

Publications and source records attributed to P Huber.

At least 145 records · Page 8Linked to original sources
PubMed1988

[Results of resection of the esophagus in cancer].

Since 1964 245 resections of the esophagus because of cancer were performed at the University Hospital of Cologne. Hospital mortality was 27%. It was reduced to 12.1% during the last 5 years. Surgeon's experience turned out to be of major influence upon hospital mortality whereas tumor and organ related risk factors or kind of the operating procedure didn't influence hospital mortality at all. Five year survival rates that included hospital mortality were 15.5% and were 23.2% without. Patient's late outcome was influenced significantly by tumor staging and histological grading. Radical operating procedure--blunt dissection or transthoracal esophagectomy--were of no prognostic value.

Adenocarcinoma↗
PubMed1987

Injury litigation and liability insurance dynamics.

Prices for some lines of liability insurance have increased sharply in recent years, even while the real amount of coverage provided has declined. What accounts for these changes? The large financial inertia inherent in the insurance business, forecasting errors repeated across the industry, and herd-like reactions among many insurers have made the market adjustments exceptionally abrupt. But the most likely underlying cause for the current crisis in liability insurance is the inexorable expansion in liability law.

Forecasting↗
PubMed1987

[Results of treatment of esophageal varix bleeding in 70-to-90-year-old patients. A prospective study].

From 1 October 1981 to 30 June 1986, 265 patients were treated for acute bleeding from esophageal or fundal varices; 61 patients were aged between 70 and 90 years. The emergency situation was treated conservatively (Sengstaken tube; transfusion; intensive laxative measures). In all cases these measures temporarily controlled the bleeding and rapidly stabilized the patient's condition. Treatment of the varices with methods of intravascular high-pressure sclerosing followed ten hours later. There was no significant difference in survival rate between those over and those under 70 years. After 24 months about 50% of patients in both groups were still alive. It is concluded that sclerosing offers to very old patients a genuine chance of survival. Long-time prognosis depends on factors which are not related to the sclerosing method.

Aged↗
PubMed1987

Characterization of the 5'-flanking region for the human fibrinogen beta gene.

To identify the possible regulatory sequences in the genetic expression of fibrinogen, a human genomic DNA library raised in lambda EMBL 4 phage was screened using cDNA probes coding for the A alpha, B beta and gamma chains of human fibrinogen. The entire fibrinogen locus was characterized and its organization analysed by means of hybridization and restriction mapping. Among the clones identified, a single recombinant lambda phage contained the beta gene and its 5'- and 3'-flanking regions. A 1.5 kb fragment of the immediate 5'-flanking region was sequenced and S1 mapping experiments revealed three transcription start points. Comparison of this sequence with that previously reported for the same region upstream from the human gamma gene revealed no significant homology which suggests that the potential promoting sequences of these genes are different. In contrast, comparison of the 5'-flanking regions of human and rat beta genes revealed a 142 bp sequence of 80% homology situated 16 bp upstream from the human beta gene. This highly conserved region may well represents a potential candidate for a regulatory sequence of the human beta gene.

Amino Acid Sequence↗
PubMed1987

HB Q-Thailand-HB H disease in a Chinese living in Geneva, Switzerland: characterization of the variant and identification of the two alpha-thalassemic chromosomes.

Data on a 24-year-old Chinese male with Hb Q-Thailand-Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse-phase high-performance liquid chromatography. Gene mapping analyses identified the alpha-thalassemia-2, which is associated with the alpha-Q chain, as caused by a 4.2-kb deletion involving the alpha 2 globin gene, while the alpha-thalassemia-1 anomaly was the common Southeast Asian type in which part of the psi zeta, the psi alpha, and the alpha 2 and alpha 1 globin genes are deleted.

Adult↗
PubMed1987

Accuracy of high resolution computed tomography in direct diagnosis of cerebral aneurysms.

With high resolution computed tomography (CT) of the skull, performing rapid series of 1.5 mm slices during an intravenous bolus injection of contrast medium, an angiography-like image (angio-CT) of the basal cerebral arteries can be obtained. From 76 consecutive angiographically or autopsy-verified cerebral aneurysms of various size down to 3 mm in diameter, 74 (97.4%) were shown up by the angio-CT. One ruptured and one incidental aneurysm escaped CT visualization. Besides the correct localization of the aneurysms, angio-CT provides information concerning the size and main direction of the aneurysms and yields, in addition, a coronal view of the aneurysms and their surrounding structures. Pitfalls for mis-diagnosis can be the following: Aneurysms of below 5 mm in diameter, located at the supraclinoid part of the carotid artery, multiple or non-ruptured aneurysms, bony or movement artefacts, poorly contrasted vessels due to wrong injection technique of contrast medium or vasospasm, and incorrect interpretation.

Cerebral Angiography↗
PubMed1987

[Surgical therapy of squamous cell carcinoma of the esophagus--limited radical intervention].

Within 23 years 237 esophageal resections were performed in patients with carcinoma of the esophagus. 115 had epidermoid cell carcinoma. After resection of the esophagus 15.3% survived 5 years. The follow-up rate over the whole period is 96%. In respect to survival only the degree of differentiation, the stage and the hospital lethality significantly influence survival. In historical comparison the blunt dissection was able to lower hospital lethality. This could not be shown in our material within a comparable time. In order to evaluate the outcome after 5 years in regard to radical transthoracic operation and blunt dissection we did a matched-pairs-analysis. There was no difference in both groups.

Carcinoma, Squamous Cell↗
PubMed1987

The coronal suture, a useful bony landmark in neurosurgery? Craniocerebral topography between bony landmarks on the skull and the brain.

In the present study the variation of the localisation and the course of the coronal suture (CS) was examined on the lateral skull X-ray. The study shows a variation of the localisation and course of the CS from the average position within +/- 4 mm in 65-77% and extreme differences between minimum and maximum values between 16 and 21 mm. The CS has also a considerable variation in its localisation relative to the precentral gyrus. Additionally the craniocerebral relationships and the localisation of the precentral gyrus and pyramidal tract are altered by the lesion or the space occupying process itself. A more exact localisation of the precentral gyrus, respectively the pyramidal tract can be obtained with CT and intraoperative cortical stimulation of the motor strip.

Brain↗
PubMed1987

Neurosonographic and biochemical correlates of periventricular leukomalacia in low-birth-weight infants.

The incidence of periventricular leukomalacia (PVL) was investigated by ultrasound in a group of 119 consecutively scanned low-birth-weight infants during a period of 3 years. The overall incidence of PVL was 6.7% while the incidence of peri-intraventricular hemorrhage was 44.5%. Ultrasound evidence of posthemorrhagic lesions was seen early and related strongly to follow-up findings. Evidence of cystic degeneration appeared later. The presence of PVL was confirmed by computed tomography at 5 months of age and anticipated by serial measurements of creatine kinase brain isoenzyme performed in the first 60 h of life. A significant correlation was observed between neurosonographic findings of PVL and high cord blood values of enzymatic pattern (p less than 0.02). Both were correlated with poor neurodevelopmental outcome at 12 months corrected age.

Brain↗
PubMed1986

[Hb Q-H: study of in vitro globin chain synthesis in reticulocytes and erythroblasts].

The case is reported of a 24-year-old Chinese patient with congenital hemolytic anemia (Hb 95 g/l, MCV 71 fl, MCHC 29 g%, reticulocytes 165% RBC). Clinical examination revealed jaundice and marked splenomegaly. Isoelectric focusing of Hb and Hb chains showed the absence of HbA, the presence of rapid Bart's and H Hb and the presence of an alpha chain variant alpha Q-Thailand, alpha 74 Asp----His (confirmation by fingerprinting of Hb). In vitro globin chain synthesis in reticulocytes and erythroblasts indicates that this variant is localized in an alpha-thal-2 chromosome. Furthermore, this variant does not exhibit any transcriptional defect of the alpha Q gene or any instability, since its association with a second alpha-thal-1 chromosome leads to a deficit of alpha chain production identical to that observed in Hb H disease (alpha alpha 0/alpha 0 alpha 0).

Adult↗