Biomedical subjects
P Holmes
Publications and source records attributed to P Holmes.
Neurophysiological and pharmacodynamic studies on caffeine and on interactions between caffeine and nicotinic acid in the rat.
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Computerization of a hospital clinical microbiology laboratory.
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H2-producing bacteria in digesting sewage sludge isolated on simmple, defined media.
Twenty percent of bacteria isolated on simple, defined anaerobic media produced H2. Eighty-four percent of these were isolated on glucose. All were Enterobacteriaceae, primarily Citrobacter.
Care of the dying. Two patients.
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A clinical isolate of Salmonella typhi requiring anaerobic conditions for primary isolation.
An unusual isolate of Salmonella typhi from a patient with typhoid fever is described. The organism grew only on anaerobic subculture from multiple blood cultures. After repeated transfer the organism adapted to aerobic growth but still required carbon dioxide.
Fenspiride -14 C: its distribution, excretion and metabolism in the rat.
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Effects of Trypanosoma congolense and nutritional supplements in Djallonké ewes on live weight during pregnancy, post partum weight, haematology parameters and lamb performance.
The effects of Trypanosoma congolense infection and nutritional supplements on live weight changes during pregnancy, haematology traits and offspring performance were studied in 42 Djallonké ewes. A randomised block design was used to allocate ewes to four treatment combinations, of which two were on a restricted diet (L) and the remainder on an unrestricted diet (H). Half of each nutritional group were infected with T congolense (LI, HI), the remainder serving as controls (LC, HC). The degree of anaemia following infection was similar in both infection groups (P<0.0001), but the erythropoietic activity, as judged by the increase in mean corpuscular volume, was significantly greater in the HI group (P<0.01). Live weight gains during pregnancy attributable to higher supplements were significantly depressed by infection (P<0.01). Post partum weight was lower in the LI group as compared with the LC control. Diet interacted significantly (P<0.01) with infection and resulted in the lowest lamb growth rates in the LI group. It was concluded that dietary supplementation of trypanosome-infected Djallonké ewes during pregnancy and lactation improves productivity in terms of ewe live weight and improved lamb growth rates to weaning.
A mixed blessing.
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The patient's friend.
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