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Biomedical subjects

P Hermanek

Publications and source records attributed to P Hermanek.

At least 163 records · Page 9Linked to original sources
PubMed1987

[Possibilities of DNA impulse cytophotometry in kidney cancers].

DNA flow cytometry (DNA-FCM) is a modern technique allowing quantitative tumor cell analysis. In tissue samples from 62 renal carcinomas, ploidy was determined and cell cycle analysis performed by DNA-FCM. We checked for correlation between the FCM data and the tumor stage according to Robson the histological grade after Hermanek, and the condition according to the combined staging and grading system. With reference to the stage-grade system, the DNA aneuploidy rate increased significantly from tumors with increasing degree of malignancy. Tumors classed according to Robson's classification system as highly malignant exhibited higher DNA aneuploidy rates. The 15 tumors that had metastasized showed higher DNA indices and higher proportions of cells in S-phase than did the 47 tumors without metastases. When used in conjunction with the stage-grade classification for renal carcinomas, DNA-FCM analysis provides useful information about the proliferative behavior, including the susceptibility of these tumors to chemotherapy.

Adult↗
PubMed1987

[TNM classification of malignant tumors: the new 1987 edition].

A new edition of the TNM classification of malignant tumours will be published in spring 1987 by UICC. This 4th edition is an internationally uniform and updated classification of tumours by their anatomical extent and is indispensable for treatment planning and evaluation of treatment results in cancer patients.

Germany, West↗
PubMed1986

Early (microinvasive) colorectal carcinoma. Pathology, diagnosis, surgical treatment.

The term early colorectal carcinoma is used for an infiltrating carcinoma with submucosal spread, but no involvement of the muscle coat (muscularis propria). Our experience with 249 such tumours is reported. Lymph node metastases were detected in only 3% of 130 patients subjected to classical surgery. Early colorectal carcinoma represents a cancer stage with an excellent prognosis (age-corrected 10-year survival rate 100%). The survival rates after limited therapeutic procedures (endoscopic polypectomy, local surgical excision, segmental/tubular resection) or after classical radical surgery do not differ significantly provided that certain selection criteria are strictly observed.

Adenocarcinoma↗
PubMed1986

Problems of pTNM classification of carcinoma of the stomach, colorectum and anal margin.

The pTNM classification of the UICC which has been valid since 1978 in some sections contains unclear definitions regarding gastro-intestinal tumours which require interpretation. In practice, this leads to variations in opinions and to a lack of uniform classification of tumour spread. The uniform measures which we have undertaken since 1969 at the University of Erlangen were described and explained. In the meantime these measures have been adopted by the DSK (German-Speaking National TNM Committee) and will to a large extent appear in the fourth edition of the TNM classification of the UICC.

Anus Neoplasms↗
PubMed1986

Is the adenoma-carcinoma sequence contradicted by the differing location of colorectal adenomas and carcinomas?

This article takes a look at the different localisation of colorectal adenomas and carcinomas. The risk of malignancy of 4,257 adenomas found in 1742 patients was determined, and the lesions grouped in accordance with various criteria and risk classes. It was found that the distribution of adenoma locations approximated all the more closely to the distribution pattern of carcinoma sites, the higher the malignancy risk of an adenoma group was. The statistical approximation of adenoma and carcinoma localisations as a function of increasing risk of malignancy must be considered an argument in support of the adenoma--carcinoma sequence.

Adenoma↗
PubMed1986

Gastrointestinal carcinoma--are there age-related differences in tumor behavior?

Among the gastric cancers, the percentage of diffuse carcinomas decreases with increasing age, while the incidence of the intestinal type increases markedly (up to 50 years 29.6%, older than 70 years 61.5%). Accordingly, in patients older than 70, gastric carcinomas limited to the antrum are seen significantly more frequently (32.5%) than in younger patients (21.1%). In patients aged 70 years or less, the rectum is more frequently affected than the colon (ratio 1.41:1), than is the case in older patients (1.17:1). With respect to stage distribution and the pTNM classification, colorectal carcinomas and gastric carcinomas show only small age-related differences. The prognosis of both carcinomas is independent of age when the survival rates are corrected for age, post-operative mortality is excluded, and only patients with identical stages are compared. In patients older than 70, cancer is not less aggressive, but, as a result of the limitations of therapeutic possibilities, and greater side effects of treatment, is more dangerous than in younger patients.

Adenocarcinoma↗
PubMed1986

Prognostic factors in stomach cancer surgery.

The most important tumour-related prognostic factors in gastric carcinoma are the depth of infiltration and lymphatic spread. The tumour site itself did not significantly influence prognosis. Histological type according to the WHO classification as well as the histological degree of malignancy were of no significance. Lauréns classification offers no great prognostic difference for tumours within the same stage, but at the time of diagnosis, diffuse type generally shows a more advanced stage than intestinal type. Prognosis is decisively influenced by the choice of surgical therapy, especially by whether the tumour can be curatively removed or not, and by the margins of clearance obtained in curative surgery. The extent of these margins of clearance should be chosen bearing in mind the differences between growth behaviour of intestinal and diffuse type carcinomas. In this fashion, a histology-oriented surgical approach can be achieved.

Humans↗
PubMed1985

The analysis of mononuclear cell infiltrations in colorectal adenocarcinoma.

Mononuclear cell (MNC) populations in tissue specimens from 11 colorectal adenocarcinomas and 1 mucinous adenocarcinoma were analyzed, applying different monoclonal antibodies (MoAB). Tumor epithelium could be characterized by MoAB VEP9, predominantly binding to mucus secreted by the tumor cells. In approximately 30%-50%, the tumor epithelium also reacted in a patchy pattern with the MoABs OKT10 and OKIa, which define in the peripheral blood activated and HLA-DR expressing cells. T-lymphocytes, as defined by the MoAB 9.6, and T-lymphocyte subpopulations, as characterized by the MoABs OKT4 and OKT8, were found in the intratumoral stroma and in peritumoral inflammatory areas. Quantifying the relative amounts of mononuclear cell subpopulations in the different stroma compartments, a predominance of OKT10- and OKIa-defined and MoAB-S39-reactive cells was observed. NK cells, as labelled by the MoAB Leu-7, were only demonstrated singularly in different areas of the stroma. Nonlymphoid structures such as vessel walls were shown to express antigens recognized by the MoABs OKIa, OKT10, and Leu-7. In some instances, nerve structures were labelled by the MoABs OKIa, OKT10, S39, and Leu-7. Using semiquantitative analysis, no correlation could be obtained between the intratumoral and peritumoral infiltration with T-lymphocytes, T-lymphocyte subpopulations and monocytic cells, and histopathological tumor grading and staging.

Adenocarcinoma↗