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Biomedical subjects

P Hermanek

Publications and source records attributed to P Hermanek.

At least 145 records · Page 8Linked to original sources
PubMed1988

[General tumor pathology and pathophysiology].

The clinical behaviour of malignancies is characterized by four stages of progressive development: local, locoregional, mono- or oligotop-distant, and disseminated-distant. In the first three stages surgery is the most effective means of treatment. The possibility of tumor cell dissemination and implantation within the surgical area determines the methods of oncological surgery (no touch, wide margins of clearance, en bloc resection together with lymph node dissection).

Humans↗
PubMed1987

Dysplasia in the gastrointestinal tract: definition and clinical significance.

The term "dysplasia" is used increasingly in gastrointestinal pathology. Dysplasia denotes an unequivocal neoplastic epithelial alteration without invasive growth and is synonymous with the term "intraepithelial neoplasia." Dysplasia is the paradigm of a precancerous lesion. Confusion arises because some pathologists do not use the term in the above-defined sense but to describe regenerative, inflammatory and reactive changes. It is essential to separate these kinds of non-neoplastic epithelial changes from neoplastic dysplasia because the clinical consequences are completely different. The general morphology and the grading of dysplasia are described. Most dysplasias in the gastrointestinal tract are the polypoid lesion; dysplasias in flat mucosa are uncommon. Knowledge of the incidence of dysplasia in the gastrointestinal tract is important for the concept of secondary cancer prevention.

Gastrointestinal Neoplasms↗
PubMed1987

[Stomach cancer: pathologic anatomy, advantage and disadvantages of the TNM system].

In gastric cancer surgery, the extent of the margins of clearance should be chosen according to Laurén's histological classification. Prognosis is decisively influenced by the R (residual tumor) classification and--after curative surgery (R0)-by the stage grouping newly defined by the UICC (1987). The present stages-based on the anatomical extent (TNM/pTNM)-should be expanded to "prognostic groups" which would take into consideration other additional important prognostic factors and therapeutic procedures.

Humans↗
PubMed1987

[Current status of the therapy of rectal cancer].

Changes have taken place in the methods used for surgery of rectal carcinoma. The primary tumour is removed and the regional lymphatic drainage area left behind, when limited techniques are chosen, that is in cases in which the risk of lymph node metastasis is not significant. Such indication is based on the careful histopathological examination of the locally removed primary tumour. Differential indications are described, with reference being made to excision of the rectum as compared to anterior and deep anterior resection. Palliative tumour resection and surgical removal of hepatic metastasis improve the prognosis. Radical tumour resection requires complete mobilisation of the left colonic flexure, high ligature of the inferior mesenteric artery, and--in cases of extraperitoneal tumours--dissection along the fascias. Tubular resection of the rectum is indicated for early rectal carcinoma as well as in cases of large villous or tubular adenomas. Reference is made to adjuvant chemo- and radiotherapy.

Combined Modality Therapy↗