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Biomedical subjects

P Henry

Publications and source records attributed to P Henry.

At least 145 records · Page 8Linked to original sources
PubMed1990

Applicability of osseointegrated oral implants in the rehabilitation of partial edentulism: a prospective multicenter study on 558 fixtures.

Nine clinical centers using the Brånemark System participated in a prospective study of 159 partially edentulous patients between 18 and 70 years of age. Clinical parameters evaluated were plaque index, gingivitis, pocket depth, bleeding index, tooth mobility, and stomatognathic function. Initially, 558 fixtures were placed and 521 remained in the study following prosthesis placement (199 prostheses in 154 patients). Fixtures were lost or unaccounted for because of nonintegration prior to prosthesis fabrication (19), patient withdrawal (11), prosthodontic reasons (6), and failure during prosthetic procedures (1). Failure was primarily attributable to unfavorable bone quality, sex (more in males), and smaller fixture size. Complications and failure related to other patient characteristics are presented. After 1 year of a 5-year study, preliminary results suggest that a success rate equal to or better than that obtained with edentulous patients may be expected.

Adult↗
PubMed1990

Clinical evaluation of angulated abutments for the Brånemark system: a pilot study.

Where fixture placement and inclination had not been optimal from a restorative perspective, angulated abutments were used to overcome compromised esthetic and functional results in situations of complicated anatomy. The angulated abutment is a treatment adjunct that provides flexibility for ensuring successful treatment when a variety of reconstruction problems are confronted.

Dental Abutments↗
PubMed1990

[Recurrent herpetic encephalitis].

A 64 year-old woman experienced, at 6 weeks' interval, two episodes of encephalitis with left hemiparesis, coma and signs of meningitis. Paraclinical examinations showed lymphocytic meningitis, right temporal hypodensity at CT and high titers for herpes simplex at blood serology. The spontaneous course was favourable with almost complete recovery. A third recurrence took place 2 months later with left hemiplegia, confusion and meningism. A tentative diagnosis of herpes simplex encephalitis was confirmed by major intrathecal synthesis of herpes virus specific antibodies and by highly suggestive MRI images. Treatment with acyclovir resulted in rapid regression of motor deficit and meningism, but neuropsychological disorders regressed more slowly with persistent visuo-constructive and memory disorders. During a fourth and milder recurrence, a stereotactic temporal brain biopsy was performed, which showed lesions of encephalitis and elevated titers for HSV1 in the temporal fluid. Another course of acyclovir followed by vidarabine produced complete remission. The possibility of recurrent types of herpes simplex encephalitis is discussed.

Acyclovir↗
PubMed1989

Endogenous L-dopa in the rat dorsal vagal complex: an immunocytochemical study by light and electron microscopy.

The aim of this work was to examine L-DOPA immunoreactivity (L-DOPA-IR) in the dorsal vagal complex (DVC) of the rat medulla oblongata containing A2/C2 catecholaminergic cell groups, in order to further evaluate the previously proposed hypothesis that various pools of endogenous L-DOPA could be immunocytochemically demonstrated in the mammalian brain. For this purpose, L-DOPA-IR was studied in DVC in comparison with both some other catecholaminergic areas and dopamine immunoreactivity (DA-IR) on adjacent sections of the same brain, by using specific antibodies against glutaraldehyde conjugated L-DOPA and DA. Also, the first preliminary observations of L-DOPA-IR in DVC neurons at the ultrastructural level are reported. The following main results were obtained: (1) bright, intense and homogeneous L-DOPA staining was found in perikarya and proximal neuronal processes situated within the rostrocaudal extension of the DVC; (2) this staining pattern was readily distinct from weak and heterogeneous DA staining; (3) an inverse L-DOPA/DA staining pattern ratio was identified between the DVC and the mesencephalon; (4) L-DOPA-IR at electron microscopic level was roughly similar to that previously observed for DA-IR in mesencephalic cells and their presumptive projections. Although some discrepancies were noticed between L-DOPA staining and data from the literature on tyrosine hydroxylase labeling, our results could not invalidate the hypothesis that, among high L-DOPA/DA ratio containing neurons, some cells in the DVC may contain only L-DOPA.

Animals↗
PubMed1989

[Alzheimer's disease: from morphology to pathogenic hypotheses].

Main changes of Alzheimer's disease (neuronal degeneration and death, neurofibrillary tangles, senile plaques, granulo-vacuolar degenerations) are described. Recent hypotheses concerning their causes, origin and development and their relationship with the mental changes are given.

Alzheimer Disease↗
PubMed1989

Myoclonus and adult coeliac disease.

A 56-year-old woman with coeliac disease developed myoclonus of cortical origin and palatal myoclonus with lesions of subcortical white matter on magnetic resonance imaging. Myoclonus can thus be a prominent feature of coeliac disease encephalopathy. A slight vitamin E deficiency was found but does not satisfactorily explain this myoclonic encephalopathy, which remains of unknown origin.

Celiac Disease↗
PubMed1989

Alzheimer's disease: neuropathological and etiological data.

The important pathological changes in Alzheimer's disease are described with their morphology, biochemistry and selective topography. The most significant hypotheses concerning the origin of these changes, their interrelationship and link with mental deterioration are reviewed. Some of the characteristic findings, such as neurofibrillary tangles, senile plaques, granulo-vacuolar degeneration, amyloid angiopathy, death and regeneration of neurons, are analyzed. The main neurotransmitter defects are mentioned in brief and similarities and differences between normal aging and Alzheimer's disease emphasized.

Aged↗
PubMed1989

Defective expression of basement membrane-associated C3d,g in papulonodular basal cell carcinomas.

Recent studies in our laboratory have shown that C3d,g, a 41,000-Da fragment of the third component of complement, is present along the base of the lamina densa and in the sublamina densa region of normal human epidermal basement membrane, but absent from the skin of a patient with congenital C3 deficiency. In studies of human skin, papulonodular basal cell carcinomas have served as a useful model for the investigation of various basement membrane antigens and matrix proteins. To further investigate the presence of C3d,g within epidermal basement membrane as well as examine its relationship with other known basement membrane constituents, we have analyzed serial sections of ten papulonodular basal cell carcinomas by light and immunofluorescence microscopy. In these studies, C3d,g was either absent (N = 9) or minimumly detectable (N = 1) in tumor nest basement membranes. While bullous pemphigoid and KF-1 antigens were absent (N = 6 and N = 3, respectively) or significantly decreased (N = 4 and N = 7, respectively), epidermolysis bullosa acquisita antigen was routinely present though somewhat (N = 3) or moderately decreased (N = 3). Laminin and type IV collagen were expressed normally in all tumor nest basement membranes. All constituents, including C3d,g, were present in adjacent normal epidermal basement membrane of these tumor samples. This study has demonstrated antigenic alterations within each ultrastructural subregion of papulonodular basal cell carcinoma tumor nest basement membranes by identifying the virtual absence of C3d,g (sublamina densa) as well as a significant reduction in KF-1 (lamina densa) and bullous pemphigoid (lamina lucida) antigens. Moreover, the presence of laminin, type IV collagen, and epidermolysis bullosa acquisita antigen in tumor nest basement membranes suggests that these particular constituents neither cleave C3 nor act as essential binding sites for passive incorporation of this complement component in epidermal basement membrane. These studies give additional support to the hypothesis that C3d,g is a previously unrecognized constituent of normal epidermal basement membrane and does not represent passive incorporation of circulating C3 at this site in human skin.

Adult↗
PubMed1989

Relationship between academic achievement and measured career interest: examination of Holland's theory.

The present study was designed to examine Holland's hypothesis that person-environment congruence relates positively to academic achievement. The sample of 157 nontraditional premedical students completed Holland's Self-directed Search interest inventory. The students were enrolled in the Medical/Dental Education Preparatory Program, which is designed to increase the number of qualified applicants who are underrepresented in the medical profession. Using scores on Holland's inventory students were classified as congruent or incongruent. A cumulative grade point average and a science grade point average were calculated for each student. An analysis of variance supported Holland's Congruence-achievement hypothesis. Congruent students did in fact achieve significantly higher cumulative GPA and science GPA than did incongruent students. Implications for counseling and academic advisement as well as further research are discussed.

Achievement↗
PubMed1989

Why do parents stay overnight with children in hospitals? A survey of parents at Royal Children's Hospital.

This article is concerned with factors affecting parents' decisions to stay overnight on the wards with their children in hospital. A literature review is provided of past and present policies for parental access. The results are reported of a survey of 143 parents who stayed overnight with their children at Royal Children's Hospital in Melbourne. The survey revealed that the cost and availability of off-ward accommodation did not influence the parents' decisions, the majority of children had pre-planned stays and none were in immediate danger. The paper concludes with suggestions concerning parent accommodation in children's hospitals.

Age Factors↗
PubMed1989

[Lepromatous leprosy: clinical and electrophysiological arguments in favor of axonal multi-neuritis].

UNLABELLED: This work was undertaken because there were only few reports on neurological aspects on lepromatous leprosy. We studied 30 patients suffering from lepromatous leprosy who, at their first visit to the Institute had never been treated. The clinical examination included a quantitative evaluation of the neurological status following the method developed by Pearson. Motor and sensory nerve conduction velocities were measured: values of conduction velocity and distal amplitude were analysed and compared to those of a group of 22 healthy subjects. IN CONCLUSION: (a) There is a high frequency of clinical and especially electrophysiological neurological impairment. This impairment can be extremely precocious and may happen shortly after the first cutaneous signs. (b) Nervous impairment is diffuse, bilateral but not homogeneous. These are characteristics of mononeuritis multiplex. Impairement is predominantly sensitive and tactile sensibility is more involved than thermo-algic sensation. (c) The radial superficial nerve is the most frequently involved clinically and electrophysiologically. (d) The electrophysiological results, showing a normal or slightly reduced conduction velocity and a low amplitude of evoked potentiel are in favour of a predominantly axonal damage.

Axons↗
PubMed1989

Immunohistologic analysis of the inflammatory infiltrates associated with osseointegrated implants.

A panel of monoclonal antibodies was used in an avidinbiotin immunoperoxidase technique to provide an immunohistologic analysis of the inflammatory infiltrates in the gingiva of osseointegrated implants. A total of 27 gingival and 13 interimplant specimens was obtained from 13 patients. Eighteen of the gingival specimens were clinically healthy, while nine showed overt signs of clinical inflammation (GI = 2 or 3). All specimens showed some degree of inflammation histologically, although the size of the inflammatory infiltrate was much greater in the clinically inflamed specimens. There was no significant difference in the proportion of T (50% to 60%) or B (40% to 50%) lymphocytes in either group. The CD4:CD8 ratio also showed no significant difference: 1.6:1 in the healthy group and 2.0 in the inflamed group. Similar ratios were also found in the infiltrates of the interimplant tissue. The immunohistologic analysis suggests that the gingival lesion associated with these implants is a stable, well-controlled response.

Antibodies, Monoclonal↗
PubMed1989

A strategy for analysing multiple risk factors with application to cervical pain syndrome.

When studying the possible effects of several factors in a given disease, two major problems arise: (1) confounding, and (2) multiplicity of tests. Frequently, in order to cope with the problem of confounding factors, models with multiple explanatory variables are used. However, the correlation structure of the variables may be such that the corresponding tests have low power: in its extreme form this situation is coined by the term "multicollinearity". As the problem of multiplicity is still relevant in these models, the interpretation of results is, in most cases, very hazardous. We propose a strategy--based on a tree structure of the variables--which provides a guide to the interpretation and controls the risk of erroneously rejecting null hypotheses. The strategy was applied to a study of cervical pain syndrome involving 990 subjects and 17 variables. Age, sex, head trauma, posture at work and psychological status were all found to be important risk factors.

Adult↗
PubMed1988

Disulfiram neuropathy.

A case of sensorimotor polyneuropathy during disulfiram administration is described. This complication partially resolved after the medication was stopped. Pathological observations revealed axonal changes and neurofilament accumulation was found in a few myelinated and unmyelinated axons.

Alcoholism↗
PubMed1988

Use of sulfur hexafluoride and a three-dimensional sampling grid for evaluation of inhalation chamber performance.

Knowledge of the distribution of a toxic agent, for example, hydrogen sulfide, within an exposure chamber is essential for satisfactory inhalation toxicology studies. The use of a three-dimensional sampling grid is described for sampling inhalation chamber atmospheres containing various concentrations of sulfur hexafluoride gas as a substitute for the more toxic hydrogen sulfide.

Air↗
PubMed1988

Prevalence and risk factors of recurrent cervical pain syndrome in a working population.

The prevalence and risk factors of recurrent cervical pain syndrome (CPS) was studied in 990 workers examined while undergoing their systematic annual visit of occupational medicine. A prevalence rate of 10.2% was obtained. Using a tree-structured logistic regression analysis, a strong association between age, sex, previous head trauma extension of the neck and strenuous muscular activity during work, and the risk of recurrent CPS was obtained. Finally, an inverse association between strenuous muscular activity during leisure time and the risk of recurrent CPS was found.

Adult↗