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Biomedical subjects

P Grantham

Publications and source records attributed to P Grantham.

12 recordsLinked to original sources

Reducing pathology test misuse.

Our laboratory serves a 450-bed acute care hospital in the rapidly growing Gold Coast region. The problem facing the department comprised an almost 10 per cent yearly increase in patient numbers in the face of budgetary constraints and pressure to increase efficiency. In January and February 1992 a vigorous effort was made to reduce pathology test numbers without compromising quality of patient care. The approach adopted involved targeting 'unnecessary' tests, defined as those investigations that would not affect a clinician's management of the patient. A team effort by laboratory scientific staff and heads of clinical departments was aimed at scrutinizing the ordering patterns of junior medical staff, who generate most of the test requests. The result was a 'test per patient' figure of 8.2 for both months, calculated as the number of tests on each request form received. In comparison, for January and February of the preceding four years, 1988 to 1991, the number of tests per patient fluctuated between 9.9 and 11.8. Patterns of unnecessary ordering that emerged included duplicate ordering of identical tests due to poor communication between house-staff, too frequent repeats of tests (for example, daily liver function tests), crossmatch where low transfusion likelihood would make group-and-hold appropriate, tests generated by nursing staff, and numerous others where the result would not affect management (or indeed even be looked at!). The nearly 20 per cent drop in tests does not include those instances where all tests on a request form were disallowed and the encounter therefore not included as a 'patient' statistic.(ABSTRACT TRUNCATED AT 250 WORDS)

Clinical Laboratory Techniques↗

Practice patterns of family physicians with 2-year residency v. 1-year internship training: do both roads lead to Rome?

Are there differences in patterns of practice between actively practising physicians who have been certified after a 2-year family practice residency and matched physicians without certification who have completed the standard 1-year internship? With the use of billing files prepared by the British Columbia Medical Association a group of 65 family practice certificants in active practice in British Columbia was compared with a control group of 130 internship trainees matched by year and school of graduation, category of billing (i.e., solo or group) and region. A wide range of practice features was assessed for the fiscal years 1984-85, 1985-86 and 1986-87. No differences were detected between the groups in 1986-87 for the following practice variables: number of patients (1888 and 1842 respectively), number of personal services billed for (7265 and 7173), number of personal services per patient (3.9), amount of funding for personal services ($140,192 and $140,100) and amount per patient for personal services ($77 and $79). Age-adjusted costs for male and female patients were similar in the two groups. Of six services thought to be influenced by type of training, only maternity care generated a significantly higher number of billings in the study group (341 v. 249). These results suggest that there is no demonstrable effect of training on patterns of practice. However, the question of the effect of training on quality of care and whether the 2-year residency may have a longer effect on practice patterns should be the focus of future research.

Accounting↗

Effects of substance P and neurokinin A (substance K) on motor behavior: unique effect of substance P attributable to its amino-terminal sequence.

The effects of intraventricular injections of the neuropeptides substance P (SP) and neurokinin A (NK-A; also called substance K) on spontaneous motor behavior were examined in mice. SP and NK-A were essentially equipotent at enhancing grooming and scratching behavior, and at reducing sniffing behavior. However, SP significantly enhanced hindlimb rearing behavior, while NK-A reduced this behavior. The effects of 3 other tachykinins, physalaemin, eledoisin and kassinin, were comparable to those of NK-A, including the reduction in rearing. Thus, SP is unique among tachykinins in its potentiation of rearing behavior. It was further demonstrated that carboxy-terminal SP fragments with tachykinin activity on smooth muscle resemble NK-A, and not SP, in their effects on motor behavior. In contrast, amino-terminal SP fragments, devoid of tachykinin-like activity, reproduced the one motor effect unique to SP, enhanced rearing, while lacking those actions common to all tachykinins. The structural requirements for enhanced rearing behavior by amino-terminal fragments were quite specific, in terms of chain length and sensitivity to D-amino acid substitutions, with the natural amino-terminal hexa- and heptapeptides being most active. The implications of these findings are discussed in light of recent observations that these same amino-terminal SP fragments are produced in vivo as metabolites of SP.

Animals↗

Benzodiazepine abuse.

Benzodiazepine abuse is indicated by excessive and long-term consumption, particularly by the elderly. Side-effects associated with long-term use are reviewed with special reference to the problem of dependence. Factors predictive of such dependence are examined and procedures for its management are described.

Aged↗

Some characteristics of the purinergic nervous system in normal and sensitized airway smooth muscle.

Supramaximal electrical field stimulation was employed to produce biphasic response in segments of cervical and thoracic tracheas and in first generation of bronchi isolated from guinea pigs. This response consists of contraction (as measured by maximal active tension, ATmax) followed by relaxation (as measured by maximal active relaxation, ARmax). First, the effect of electrical stimulation was studied in relation to frequency and duration of impulse. Highest degree of relaxation (ARmax) was achieved with a frequency of stimulus of 40 pulses per sec for segments of trachea, and 60 pulses per sec for first generation bronchi, and with duration of pulse of 1.0 msec for segments of trachea, and 2.0-2.5 msec for bronchi, and with duration of pulse of 1.0 msec for segments of trachea, and 2.0-2.5 msec for bronchi. Secondly, mean length-tension relationship was determined. It was found that maximal relaxation (ARmax) occurred at 160 +/- 5% of Lmax in case of tracheal segments and 160 +/- 2% of Lmax for bronchial preparations. Using propranolol pretreatment (10(-4) M), which inhibited participation of adrenergic receptors in relaxation, it was determined that approximately 50% relaxation of airway smooth muscle of the normal guinea pig is mediated through the purinergic nervous system. Both tracheas and bronchi isolated from sensitized guinea pigs, chronically exposed to antigen, showed a significant decrease in overall relaxation (P less than 0.01). However, the per cent decrease in relaxation after propranolol was not different in sensitized animals than that found in controls. The data suggest that relaxation of segments of airways isolated from animals chronically exposed to antigen is decreased in consequence of alterations in both purinergic and adrenergic nervous systems.

Action Potentials↗

Increased insulin binding to monocytes after acute exercise in normal man.

The effect of exercise on 125I-insulin binding to monocytes was studied in 10 healthy subjects. We found that acute exercise (bicycle ergometer for 3 h) led to a significant increase (36%) in insulin binding to monocytes, which returned to basal levels by 24 h after exercise. The changes in insulin binding were mainly due to an increase in receptor affinity. The increase in insulin binding during exercise correlated with the fall in plasma glucose but not with the decrease in plasma insulin or increase in blood ketones. We conclude that acute exercise increases insulin binding which may contribute to augmented insulin sensitivity associated with exercise.

Adult↗