Biomedical subjects
Publications and source records attributed to P Frank.
Five cases of diffuse gastric spiculation seen on single contrast barium meal examination are reported. This appearance may spuriously suggest superficial mucosal ulceration in cases in which no evidence of this is found endoscopically or histologically. This radiological appearance may be due to filling of the grooves between the areae gastricae and may thus represent a normal anatomical variant.
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Of 623 cases of malignant pancreatic tumor seen at University of Chicago hospitals over the last 30 years, 23 cases of malignant islet cell tumor were found (8 additional cases were found in the literature). Calcification, found in 2 of these cases, was characteristically discrete and nodular (calcifications found in chronic pancreatitis are typically diffuse, multiple, and punctuate). At least 7 of the 10 cases of islet cell tumor with calcification were malignant. Slow growth of the tumor, with calcified metastases, strongly suggests the diagnosis of malignancy; this combination of findings has been established in 3 cases. In 73 cases of benign islet cell tumor, no calcifications were found.
An open study of four dosage regimes of clomipramine (Anafranil)--10 mg t.d.s., 30 mg o.n., 25 mg t.d.s. and 75 mg o.n.--was performed in patients seen in general practice suffering from depression. The primary purpose of the study was to gather information on steady-state blood levels of unchanged drug and major metabolite. However, clinical assessments were also made on a seventeen symptom depression rating scale initially and after 1,2 and 4 weeks treatment and side-effects were assessed. Seventy patients were admitted to the study; forty-nine completed it. All four treatment groups showed significant improvement. The groups were small and no significant differences emerged between them. The best response of 77% improvement on total score after 4 weeks was obtained in the group of patients receiving 25 mg t.d.s. The patients on 30 mg daily showed a 67% response when this was divided and 65% when given singly. The worst response was obtained in the patients receiving 75 mg single dose (50%). Thirteen of the twenty drop-outs did so because of side-effects. Ten of these were in high dose groups. However, amongst patients who completed the study there was no difference in the side-effects observed in the four groups.
Osseous anomalies of the craniocervical junction may induce grave neurological disturbances and even lead to sudden death in exceptional cases. Therefore a correct diagnosis with painstaking demonstration of the extent of all anomalies must be established. This can be achieved exclusively by roentgenological studies. Clinical symptoms can only provide a lead to the underlying disease. In the present paper, the special problems of the radiology of craniocervical malformations are discussed and illustrated with own observations, which include specimen radiography.
An increase in the number or the sudden appearance of multiple microcalcifications in the course of a mammographic controls series represent a further important sign of malignancy. In 14 of our cases witha non palpable breast cancer we were able to observe an increase in the number or a sudden appearance of typical calcium precipitates during an observation period, which, according to the case, lasted from 6 to 21 months. Biopsy revealed in all cases an early cancer. Our observations demonstrate the absolute indication for biopsy in all patients, which during a mammographic control series suddenly present microcalcifications, or an increase in the number of the ones that were previously observed. All patients showing clustered microcalcifications, which because of their small number are not demanding a biopsy, should be regarded as risk-cases and observed regularly in order to rule out or demonstrate an increase in the number of calcifications. Follow-up series within six months are recommended.
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Congenital skull changes in neurofibromatosis are uncommon. Maybe for this reason, they are often misinterpreted, consequently resulting in expensive examinations and unnecessary treatments. However, if correctly evaluated, the corresponding radiological findings represent characteristic and pathognomonic signs of the disease. Three cases of neurofibromatosis are reported, the symptoms presented in detail and the pertinent differential diagnosis discussed.
One case of calcifications in mediastihal lymphoma after radiation therapy of Hodgkin's disease is reported. The incidence of these calcifications is remarkably low. They are mostly localized in the anterior mediastinum showing a characteristical pattern which is initially stippled, later confluent and coral-shaped. An open interval after radiation therapy is typical for this phenomenon. The cause of the calcifications is discussed.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.