Search PubMedSearch

Biomedical subjects

P Doury

Publications and source records attributed to P Doury.

At least 19 recordsLinked to original sources

[The use of bone scintigraphy with technetium 99 m pyrophosphates in the diagnosis of algodystrophies. A report on 74 observations (author's transl)].

Bone scintigraphy with technetium 99m pyrophosphates was used to study a series of 74 cases of algodystrophies. Though non-specific, this investigation was the determining factor for confirming the diagnosis in more than 48% of cases, by demonstrating early bone hyperfixation, its topographical characteristics, and the return to normal conditions after 3 to 12 months. Bone hyperfixation has to be exaluated together with clinical, biological, and radiological signs when considering the diagnosis, and though in half the cases it is not indispensable for diagnosis, it is always of value for determining the amount of extension of the algodystrophic process.

Adult

[Pseudotumoral rheumatoid coxitis (author's transl)].

Two cases of rheumatoid coxitis of the macrogeodic type are reported. In one case, there was a very large anfractuous cavity in the socket and head, complicated by a pathological fracture of the socket, which raised the suspicion of a malignant tumor. The authors review the characteristics of these macrogeodic forms of rheumatoid arthritis, about forty cases having been reported in the published literature.

Adult

[Partial algodystrophy].

The authors describe, on the basis of 7 cases, a special form of decalcifying algodystrophy not described in the literature, characterized by a very localized pain beginning gradually, or more often suddenly. It is of mechanical or mixed type, accompanied by local, pseudo-inflammatory signs being either apparent or discrete, very elective and very sharp pain upon palpation of a very limited area of a condyle or a tibial plate, with hyperfixation located through scintigraphy with technetium 99m polyphosphates, and regressing either spontaneously, or more quickly under treatment, of which thyrocalcitone is the essential part, without undergoing a phase of intense loco-regional demineralization. This form of algodystrophy, that they propose to call partial algodystrophy, can, like the other forms of algodystrophy, appear in monofocal or plurifocal form, either straight off or at a distance from the first incidence, which leads this new radioclinical type to be considered a simple form of algodystrophy of the limbs, midway between the types without radiological anomaly during development and the complete and extensive ones with major radiological signs. Finally, they underline the great value or scintigraphy in diagnosing this form of algodystrophy and algodystrophy without radiologic anomaly.

Adult

[The calcaneus in the Fiessinger-Leroy-Reiter syndrome].

The authors report on 43 cases of calcaneitis seen out of 121 cases of Fiessinger-Leroy-Reiter syndrome. They describe the three developmental stages and show that the polymorphism of the radiological aspects realized depend on the very great variability of the speed of development of the pathological process from one case to another. Calcaneitis of the Fiessinger-Leroy-Reiter syndrome always ends in cure.

Adolescent

[Post-meningococcal rheumatism].

Two cases of post-meningococcal inflammatory arthritis with a relapsing course in one case are reported. The authors then recall the characteristics of the joint manifestations during meningococcal infections in the light of other cases in the literature. These arthropathies are generally aseptic and their resistance to antibiotics is remarkable, whilst non- steroid anti-inflammatory drugs, even used alone as in one of the cases reported here, are remarkably effective. The pathogenesis of these cases of arthritis is not clear: it seems however according to Greenwood and Whittle that they are manifestations of immuno-allergic type. This "post-meningococcal rheumatism" may be compared to the gonococcal rheumatism of certain cases of Reiter's syndrome.

Adult

Comparative study of the effectiveness of flurbiprofen given twice or 3-times daily.

A double-blind trial was carried out in 15 patients with ankylosing spondylitis and 15 with coxarthrosis to assess the effectiveness of 300 mg flurbiprofen daily, administered in divided doses either twice or 3-times a day. Patients were allocated at random to receive treatment for 7 days either with a morning and evening dose of 150 mg flurbiprofen plus a mid-day dose of placebo, or with 3 doses of 100 mg flurbiprofen. They were then crossed over to the alternative regimen for a further 7 days. The results, evaluated by a 5-point rating scale of pain severity and of functional activity and by overall patient and doctor assessments, showed that flurbiprofen was effective in 66% of the 26 patients completing the trial. Tolerance was also assessed as being satisfactory in 83% of all patients. Comparison of the two treatment periods showed that 2 daily doses of flurbiprofen produced as good results as the 3-times daily regimen.

Adult

[Post-meningococcal rheumatism (apropos of 3 cases)].

A report is given on 3 cases of arthritis after cerebrospinal meningitis caused by B meningococci, with a relapsing course in 1 case. The observations are compared with the literature and the characteristics of articular manifestations of meningococcal infections are outlined. Three types are distinguished. Type I is characterized by banal arthralgias masked by the symptoms of meningitis. Type II encompasses septic arthritides preceding or concurring with the meningitis and like the latter sensitive to antibiotics. Type III includes postmeningococcal arthritides with sterile articular fluid refractory to antibiotics and showing a spectacular reaction to non-steroid anti-inflammatory drugs. These arthritides constitute a true infective rheumatism, post-meningococcal rheumatism, and should be related to other post-meningococcal manifestations such as pericarditis, myocarditis, cutaneous and ocular changes. All these manifestations are attributed to the production of immune complexes. Postmeningococcal arthritides, whose characteristics are described, may occur after septic meningococcal arthritis or appear as such. The distinction of postmeningococcal rheumatism where only anti-inflammatory treatment is effective might lead to the question whether certain postgonococcal arthritides refractory to antibiotics and responding to anti-inflammatory drugs are not provoked by an immuno-allergic mechanism leading to postgonococcal rheumatism -a nosological entity that has been abandoned possibly too fully and definitively.

Adult

[Current aspects of the Fiessinger-Leroy-Reiter syndrome seen at the initial stage in a military setting].

The authors report a series of 40 recent personal cases of the Fiessinger-Leroy-Reiter syndrome seen at the initial stage in military personnel, in which post-diarrhoeal forms were combined with post-urethritis forms. They emphasize the special features of the articular lesions which alone orient the diagnosis towards this syndrome which is confirmed by the evolution and the paraclinical examinations. They also emphasize the value for diagnosis of the disease of testing for HLA B27 and also its importance with regard to the prognosis, but they show that this antigen is sometimes absent particularly subjected to numerous hostile factors related to poor hygienic conditions. The authors conclude that the presence of the HLA B27 antigen must not lead to a refusal to recognize the relation of this disease to service in patients who have been subjected to the hostile factors that have a role in the genesis of the Fiessinger-Leroy-Reiter syndrome, as this is frequent in military personnel.

Adult

[Fatigue fractures of the metatarsal bones].

The authors report 145 cases of fatigue fractures including 125 of the metartarsals. They compare this distribution that reported by others, in particular in German work. After study of the different types of clinical picture the authors emphasize the importance of repeated and high quality radiological examinations. They describe the four stages of radiological evolution. Each of the images taken out of its context is misleading. They may lead to the diagnosis being missed and thus should be well known.

Adolescent

[Dysenteric rheumatism. What remains in 1976?].

Joint manifestations that occur during or after an episode of dysentery, grouped under the name of dysenteric rheumatism, have been known since antiquity, and have been mainly found in military circles, in camps, or during military campaigns. After reviewing the principal epidemics of rheumatism complicated by joint manifestations, the authors show that the only different feature about what is called dysenteric rheumatism is the particular character of the joint manifestations which may be isolated or associated with other manifestations, notably ocular or urethral, forming then what is called the Fiessinger-Leroy-Reiter syndrome. The role of the dysentery bacillus in the genesis of the joint lesions is not clear. Although it may been suspected on the basis of epidemiological or bacteriological arguments in some cases, it has never been formally demonstrated and is often non-existent. The term dysenteric rheumatism is too restrictive and should henceforth be abandoned.

Adult

[The lymphocyte transformation test with the bedsonian antigen (bedsonian LTT) in old and recent Fiessinger-Leroy-Reiter syndromes and in ankylsoing spondylarthritis. Additional study].

The lymphoblastic transformation test in the presence of bedsonian antigen was positive in 72 per cent of the cases confirmed Fiessinger-Leroy-Reiter syndrome, while it was negative in all the controls. This test remains positive over a long period since it was found to be positive in 69.75 per cent of old cases of FLR syndrome diagnosed 13-17 years previously. In cases of post-Reiter ankylosing spondylarthritis (ASp), the bedonian LTT was positive with equal frequency as in cases of FLR syndrome not complicated by ASp (68.4 per cent). On the other hand, in the cases of ASp without known history of FLR the test was positive much less frequently (17.7 per cent). There was no significant difference between the positivity rate of the bedsosian LTT in cases of pure axial ASp and in cases of ASP with peripheral lesions, neither in the group with post-Reiter ASp nor in the group with idiopathic ASp. In addition to its diagnostic value, this test is of great value in the epidemiological study of the group of rheumatic diseases that includes the FLR syndrome and ASp.

Antigens, Bacterial