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Biomedical subjects

P Diosi

Publications and source records attributed to P Diosi.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Polymorphism of nuclear inclusions in carcinoma of the cervix uteri.

Frequency, polymorphism and ultrastructural characteristics of the nuclear inclusion bodies encountered in cancers of the uterine cervix are reported and briefly discussed. The nuclear inclusions are grouped in three distinct types: a) nuclear bodies (comprising type I and II inclusions according to Bouteille et al.'s classification), b) inclusion of cytoplasmic origin, and c) particles of chromatic material. The ultrastructural aspects of the chromatic particles suggest an early structuration of viral chromatin into core material. There appears to be a direct relation between the frequency of chromatic particles and raised antiherpetic antibodies in the patient's sera.

Adult↗
PubMedDate not supplied

The cytomegalic inclusion cell and disease. II. Social behaviour in vitro.

Upon primary cytomegalovirus infection, previously healthy individuals acutely reject the mass of virus-infected cells, by adequate cellular and humoral defence mechanisms. By contrast, the immunologically immature or compromised host, while still able to neutralize extracellular virus, will tolerate the persistence of the allenated population of cytomegalovirus-converted cells. The micropathology of cytomegalovirus-infected monolayers, however, runs a different course, due to the absence of any immune effector in the in vitro systems. In cultured monolayers of fibroblasts, the infected cells are selected out and aggregate engulfing one another to form giant multinucleated structures.

Animals↗
PubMedDate not supplied

Phosphonoacetic acid-induced morphological changes of herpesvirus growth in vitro.

Thin-section electron microscopy of Herpesvirus hominis type 1 (HV-1)-infected HEp-2 cells exposed to 100 micrograms/ml phosphonoacetic acid (PAA) revealed not only a spatial restriction of virus multiplication to a few spheroid bodies in the nucleus, but also a delay in viral development, resulting in the formation of unusual HV-1 particle rosettes around the spheroid bodies. HV-1-infected cells were lacking, however, the small tubular structures known to accumulate at increased rates in the presence of PAA, in HV-2-infected cells.

Capsid↗
PubMedDate not supplied

Ultrastructural aspects of herpetoviruses.

Thin-section electron microscopy of several herpetovirus strains recovered in the laboratory from human hosts and rodents visualized typical spherical particles when the strains were propagated in vitro at a temperature corresponding to the body temperature of their natural host. In contrast, viral growth at a suboptimal temperature often resulted in aberrant viral structures.

Animals↗
PubMedDate not supplied

100 years of cytomegalovirus research: an overview.

The early belief that CMV infection is lacking any obvious clinical or pathological feature which would permit its recognition (19) was followed by a centennial effort to delineate the genuine clinical picture of the disease, until it became evident that infections with this virus are resulting in a wide range of syndromes (6) correlated with the age (70) and/or the immune status of the host (75), rather than causing a single morbid entity. Even a given syndrome may yield various manifestations (39). Transition of one CMV-induced syndrome to another (61), and the concomitance of two different clinical aspects at distinct body sites, as well as the concurrent evolution of a localized CMV process and systemic CMV illness in the same host, have also been reported (36). Certain organ syndromes appear to be frequently associated with transplantation e.g. interstitial pneumonitis following allogeneic bone marrow grafting, or with a severely immunocompromised state, e.g. CMV retinis in AIDS patients. Maximal therapeutical immunosuppression appears to exagerate the clinical symptomatology of CMV infection, and in AIDS patients the concomitant CMV disease attains epidemic proportions and a dramatic, constantly fatal course (18). Conversely, intercurrent CMV infections may constitute a terminal lethal complication of AIDS.

Adult↗
PubMedDate not supplied

Cytomegalovirus (CMV) in cervical secretion and breast milk. A thirty years perspective.

During the past 30 years prospective epidemiologic studies have clearly established that infants commonly acquire CMV infection in the immediate perinatal or early postnatal period. CMV reaches the offspring with uterine cervical secretions during the birth process and/or with maternal milk during the breast-feeding period, usually resulting in asymptomatic infection in full-term infants. In young women cervical shedding of CMV may reflect a pelvic inflammatory disease and involves the risk of sexual transmission.

Cervix Uteri↗