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Biomedical subjects

P Diosi

Publications and source records attributed to P Diosi.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Balkan nephritis. A synthetic view on 50 studied cases.

Epidemiological, clinical pathological investigations concerning Balkan nephritis (BN) have revealed some particular aspects which define this condition as a distinct nosologic entity. Its endemic familial character and its occurrence restricted to some limited geographic areas in Bulgaria, Yugoslavia and Romania, are highly unusual. BN leads to chronic impairment of the renal function which is, however, not constantly associated with edema and hypertension. The duration of the disease is prolonged; death takes place from uremia within five to ten years. Gross pathologic changes are consisting of severe bilateral atrophy of the kidneys, with structural changes suggesting a 'renal cirrhosis'. The etiology of the disease is obscure. Investigations carried out by means of electron microscopy and immunofluorescence tests are suggesting that the pathogenesis is rather complex. The role of a persistent tolerated or slow, latent virus infection in certain families, that of some toxic factors, and the implication of autoimmune mechanisms are to be considered.

Bulgaria↗
PubMedDate not supplied

The cytomegalic inclusion cell and disease; a hypothesis.

Infections due to human cytomegalovirus are common in the general population, disease on the other hand is rare, being usually associated with the presence of cytomegalic inclusion bearing cells in the tissues. It can be inferred that in healthy individuals latently infected with this agent, such cells are promptly destroyed by the policing immune system and the efficiency of this immune surveillance is due to the high degree of antigenic disparity of cytomegalic inclusion bearing and normal cells. However, any impairment of the immune defence may render the host unable to deal with the inclusion bearing cells, which are then believed to induce at least some of the severe clinical symptoms of cytomegalic inclusion disease.

Adrenal Glands↗
PubMedDate not supplied

[Coronaviruses in pathology].

The crown-like projections on the surface of the particles permits differentiation of coronaviruses from other riboviruses and their individualization as a distinct family. Recognition of their role in the aetiology of respiratory, enteral and encephalitic infections has promoted investigations for the finding of preventive vaccines. Selection of the strains showed that their immunogenicity depends upon the density and salience of the crown-like projections, the antigenic relationship of the projections determining cross serologic reactions between different species. At present experiments are being carried out on animals with vaccines prepared with antigenically related heterologous cornavirus species, not pathogenic for the host, and with subunitary vaccines prepared from the projections of the homologous species. The Coronaviridae family established on morphologic criteria is thus confirmed by the immunologic relationship and specificity of its members.

Animals↗