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Biomedical subjects

P Curtis

Publications and source records attributed to P Curtis.

At least 91 records · Page 5Linked to original sources
PubMed1991

A critical review of labor and birth care. Obstetrical Interest Group of the North American Primary Care Research Group.

A critical review of the literature regarding important aspects of labor and delivery was conducted by members of the Obstetrical Interest Group of the North American Primary Care Research Group using computerized searches, personal communication, and literature exchange between group members. Each written topic summary was carefully reviewed by a second group member, and a consensus was reached regarding conclusions and recommendations by the group. The topics include family involvement, comfort measures, fetal heart rate monitoring, labor augmentation, birth positions, and episiotomies. Each topic summary is preceded by conclusions and recommendations given in the order of least invasive to most invasive of the woman in labor. The strength of these conclusions and recommendations is based on the amount and type of supportive data in the literature and is indicated by one to three stars preceding that statement. One-star conclusions are not well supported in the literature but reflect a family practice style and were reached through consensus from the group. Three-star conclusions are supported by data from clinical trials.

Delivery, Obstetric↗
PubMed1990

The procedural skills of medical students: expectations and experiences.

The procedural skills that medical students should learn were identified by a survey of faculty and residents at the University of North Carolina at Chapel Hill School of Medicine in 1985. Those who responded indicated that it was important for students to have exposure to all 52 procedures listed on the questionnaire. Only a small number of procedures were identified by 75% or more of those who responded as being important for students to perform with proficiency (11 procedures identified by the faculty, nine by the residents). On another questionnaire, the graduating medical students indicated that, for the most part, they had experience performing these important procedures. To ensure clinical competency, expectations regarding these skills should be communicated to students, faculty, and residents and, ideally, a system should be established to assess these skills.

Clinical Clerkship↗
PubMed1989

Physical and mechanical properties of anterior and posterior composite restorative materials.

The physical and mechanical properties of two photo-cured anterior filling materials and a photo-cured posterior filling material have been compared with those of a conventional-cure resin composite. The properties of these materials were found to be dependent on their matrix resin compositions, filler contents, and filler particle sizes. One material with a low (50%) inorganic filler content of small particle size (0.04 micron) was found to have a lower mechanical strength with significantly higher water sorption and solubility characteristics than more heavily filled materials. A new hybrid photo-cured anterior composite with a smaller filler particle size was found to have comparable sorption and solubility behavior but a tensile strength superior to that of a conventional-cure composite. The superior properties of the new photo-cured systems are thought to result from their hybrid composite structures and the smaller filler particle sizes.

Composite Resins↗
PubMed1989

The effects of gamma radiation on the properties of composite restorative resins.

The effects of gamma radiation at therapeutic dosage levels on the physical properties of three anterior (two light-cured and one autocure) composites and a light-cured posterior composite were studied. Gamma radiation had no effect on the autocured composite but had varied effects on the light-cured systems. The diametral tensile strength and dimensional stability were unaffected, water sorption and solubility were reduced but surface and bulk hardnesses were increased with the hardness increases linearly related to the radiation dosage. These effects may arise from continued polymerization of the air-inhibited surface layer and possibility of low molecular weight entities within the matrix. Overall, therapeutic levels of gamma radiation had no detrimental effects on the physical properties of the composite resins.

Adsorption↗
PubMed1989

The mouse carbonic anhydrase I gene contains two tissue-specific promoters.

We report the isolation and characterization of the mouse carbonic anhydrase I (CAI) gene. Direct RNA sequence analysis of the 5' nontranslated regions of CAI mRNA from mouse colon and mouse erythroleukemia cells demonstrated tissue specificity in the lengths and sequences of CAI transcripts. Analysis of several mouse CAI genomic clones showed that the transcripts arose from a single CAI gene with two tissue-specific promoters and eight exons. CAI transcripts in the colon were found to initiate just upstream of the erythroid exon 2 of the CAI gene region sequence. Erythroid transcripts originated from a novel promoter upstream of exon 1, which was located more than 10 but less than 250 kilobases upstream of exon 2. Erythroid exon 1 contained only a nontranslated sequence, which was spliced to exon 2 via a cryptic splice acceptor site located in the region that encoded the colon mRNA 5' nontranslated sequence. The remaining exon-intron junctions were conserved in comparison with those of the CAII and CAIII genes.

Animals↗
PubMed1989

Infant care: the value of the six week check.

A review of the routine six week post-natal examination of the well-baby was performed. Eighty-one percent of infants born in the Rotunda attended for a hospital based review during the study period and 42% of these had experienced some problem during the six weeks from birth (rashes 20%, snuffles 10.7%, irritability 7.6% and eye infections, constipation, diarrhoea, vomiting, cyanotic/breath holding episodes). These problems were dealt with by the hospital outpatient department (55%), the mothers themselves (30%), general practitioners (12.5%) and public health nurses (2.5%). Significant problems not detected at birth were present in 12 infants (3%) and eight infants (2%) required hospital admission. This review illustrates a relatively low rate of problems not previously detected and that the majority of problems arising in the first six weeks of life require advice alone. There is also clearly scope for improving the community based services and increasing their involvement in this aspect of infant health.

Community Health Services↗
PubMed1989

Patterns of uterine contractions and prolonged uterine activity using three methods of breast stimulation for contraction stress tests.

The contraction patterns in 378 breast-stimulated contraction stress tests administered to 213 women are described. The subjects were assigned sequentially to one of four intervention groups: bilateral manual breast massage, unilateral pump stimulation, heating pad stimulation, and placebo. There was a marked increase in the proportion of tests with three to four contractions in 5-minute intervals after the interventions occurred. Twenty-five percent of all tests showed prolonged uterine activity, occurring most frequently in women with postdate gestations using manual massage or breast pump stimulation. The duration of prolonged contractions ranged from 1.5-8 minutes, with 19% lasting from 4.5-8 minutes. There was no difference in the incidence of fetal heart rate abnormalities between tests with and without prolonged uterine activity, and no late decelerations occurred in tests with tachysystole.

Adolescent↗
PubMed1988

Physicians' attitudes to after-hours callers: a five year study in a university based family practice centre.

A study of 8179 after-hour calls over a five year period is reported from a single training family practice centre. The analysis of the perceived validity of after-hours calls and the physicians' reactions to these contacts showed important differences with regard to patients' race, sex and age and frequency of calls per patient. Negative attitudes were particularly evident in relation to frequent users of after-hours services, black female patients, psychological problems and calls for prescriptions. Possible explanations for these differences are discussed.

Appointments and Schedules↗
PubMed1988

Impact of an HMO on a university-based family practice program.

The impact over a 12-month period of a major increase in enrollment of prepaid insurance patients on the clinical, administrative, and educational activities of a university-based family practice residency program is described. Patient services increased by 40 percent, placing a heavy clinical load on faculty and third-year residents. There were significant increases in referral to psychology, psychotherapy, ophthalmology, and otolaryngology specialists. The high demand for services caused logistical difficulties for office and nursing staff. Adaptation to these changes and cost-containment efforts were hampered by institutional relationships. Strategies to manage the impact included hiring additional staff and part-time clinicians, introducing quality assurance and internal control procedures, and repeated orientation to the prepaid plan. Overall, the impact of the plan was of educational value to both residents and faculty.

Ambulatory Care Facilities↗
PubMed1987

Chimeric antibody with human constant regions and mouse variable regions directed against carcinoma-associated antigen 17-1A.

We have cloned the genomic DNA fragments encoding the heavy and light chain variable regions of monoclonal antibody 17-1A, and we have inserted them into mammalian expression vectors containing genomic DNA segments encoding human gamma 3 and kappa constant regions. The transfer of these expression vectors containing mouse-human chimeric immunoglobulin genes into Sp2/0 mouse myeloma cells resulted in the production of functional IgG that retained the specific binding to the surface antigen 17-1A expressed on colorectal carcinoma cells.

Amino Acid Sequence↗
PubMed1987

A benefit of spinal manipulation as adjunctive therapy for acute low-back pain: a stratified controlled trial.

Fifty-four subjects volunteered to participate in a controlled study contrasting spinal manipulation with spinal mobilization without the rotational forces and leverage required to move facet joints. All suffered from regional low-back pain for less than 1 month, were ages 18-40, had never previously undergone any form of spinal manipulation, and denied a prior episode of backache within the previous 6 months. Randomization was stratified at outset into those who suffered for less than 2 weeks and those whose discomfort had persisted for 2-4 weeks. Outcome was monitored by a questionnaire assessing functional impairment. A treatment effect of manipulation was demonstrated only in the strata with more prolonged illness at entry. In the first week following manipulation, these patients improved to a greater degree (P = .009, t test) and more rapidly (P less than .025, Wilcoxon rank-sum test).

Acute Disease↗
PubMed1987

Uterine hyperstimulation. The need for standard terminology.

The incidence of uterine hyperstimulation during oxytocin augmentation in labor and in breast-stimulated and oxytocin contraction stress tests showed a wide variation in a number of reported studies. One major reason is the lack of a standard definition of uterine hyperstimulation.

Female↗