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Biomedical subjects

P Coulanges

Publications and source records attributed to P Coulanges.

At least 127 records · Page 7Linked to original sources
PubMed1984

[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. I. Study in two regions of the west coast].

Two three weeks field studies were performed in Morondava (West Coast) and Nosy Be (North West Coast) respectively in January and April 1983. Among 110 malarial patients recruited through passive detection, 70 in vivo tests and 37 in vitro tests were performed. In vivo, within 7 days 10 mg/kg chloroquine failed in 8 of the 21 treated patients, 25 mg/kg chloroquine failed in 1/43 and none of these patients treated with 10 mg/kg amodiaquine failed. In vitro, 5 among 37 isolates had chloroquine IC50 more than 250 nM/1 which is predictive for resistance with the semi-microtest. All isolates were sensitive in vitro to low doses of amodiaquine, piperaquine and dichlorquinazine.

Adolescent↗
PubMed1984

[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. II. Study in two regions of the east coast].

In Manakara and Foulpointe (East Coast of Madagascar) 184 malarial patients were selected among 742 patients attending dispensaries. The 7 days in vivo tests was performed in 144 patients. 13/36 failure to alternative (10 mg/kg) and 1/61 failure to standard (25 mg/kg) chloroquine WHO tests were observed. 10 mg/kg oral amodiaquine failed within 7 days in 5/47 patients. The in vitro semi-microtest was performed with 27 isolates. 2/24 Plasmodium falciparum isolates were chloroquino-resistant (IC50 = 270 and 280 nM/1), 27/27 were sensitive to low doses of amodiaquine (max IC50 = 76 nM/1), 25/25 were very sensitive to dichlorquinazine (max IC50 = 83 nM/1) and with pipéraquine 22/24 were very sensitive (IC50 less than 75 nM/1) and 2 less sensitive (IC50 = 240 and greater than 140 nM/1).

Aminoquinolines↗
PubMed1984

[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. III. Studies in three regions of the interior].

Among 273 malarial patients recruited through passive detection, 177 in vivo tests were performed in Andekaleka and Ankazobe and 23 in vitro tests in Ifanadiana, and Ankazobe (inland of Madagascar). In vivo, chloroquine failed within 7 days at 10 mg/kg in 28/86 patients, at 25 mg/kg in 7/34 and amodiaquine failed in 5/55 with 10 mg/kg and in 0/14 with 25 mg/kg. In vitro, the semi-microtest revealed resistance to chloroquine of 1/23 isolates (IC50 = 750 nM/1) but high sensitivity to amodiaquine, dichlorquinazine and piperaquine of all studied isolates (max IC50 = 92 nM/1).

Aminoquinolines↗
PubMed1984

[Drug sensitivity of Plasmodium falciparum in Madagascar. V. Study of the in vitro activity of quinine, mefloquine and halofantrine].

In a nine month fields study in 1983 in Madagascar, in vitro sensitivity to others drugs than 4 aminoquinolines were tested for 39 Plasmodium falciparum isolates, including 2 chloroquine resistant ones. Sensitivity to quinine, mefloquine and halofantrine were recorded from 28, 39 and 11 of these isolates respectively. IC50 with semi-microtest were under 20 nM/1 for mefloquine, under 12 nM/1 for halofantrine and under 560 nM/1 for quinine. All these values are under maximal values observed elsewhere with isolates coming from patients successfully treated with the three drugs.

Antimalarials↗
PubMed1984

[Exceptional resistance of Malagasy plague-transmitting fleas to insecticides].

Two plague transmitting malagasy fleas S. fonquerniei and X. cheopis, caugh in the cities of Tananarive, Antsirabe-Betafo and Ampefy were tested in conformity with WHO standards. These two fleas were resistant to DDT, dieldrin and malathion, Moreover, X. cheopis from the cities of Tananarive and Antsirabe-Betafo were resistant fenitrothion and propoxur. It seems to be first description of simultaneous resistance to organochlorinated, organophosphorylated and carbamylated products. The authors discuss the causes of this exceptional phenomenon, and make some suggestions in order to obtain a better knowledge and understanding of this phenomenon.

Animals↗
PubMed1984

[Rift valley fever and Zinga virus: a pathogenic arbovirus in man and animal new for Madagascar].

Virus Zinga strains have been isolated from several pools of mosquitoes collected in Perinet area, 130 km far from Tananarive, at the Institut Pasteur of Madagascar in 1980. Although this virus is pathogenic for man, it seemed to give only a mild illness and did not appear to constitute a problem of Public Health. But today it is seen in quite a different way; since the WHO Center for Arbovirus Reference and Research of New Haven has shown the serologic identity between virus Zinga and an another arbovirus, Rift Valley Fever virus. This latter is in fact very pathogenic for man and domestic animal, he is responsible of important epizootics characterized by many abortions in pregnancies and death of newborn animals, many infections have occurred in man during these epizootics and the disease is able to give a mortal haemorragic syndrome. Until now, no particular aggressivity has been shown by virus Zinga in Madagascar, but it remains a real potential danger for man and for domestic animals.

Animals↗