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P Collignon

Publications and source records attributed to P Collignon.

At least 37 records · Page 2Linked to original sources
PubMed1997

Inherited DNA amplification of the proximal 15q region: cytogenetic and molecular studies.

In a 15 year old girl, referred for growth retardation, conventional cytogenetic analysis detected an abnormal 15q+ chromosome with extra material in the proximal region, inherited from her father and grandfather. Using various molecular cytogenetic techniques, including comparative genomic hybridisation, we showed that the extra chromatin resulted from in situ amplification of DNA sequences located between the loci D15Z1 and D15S18. On the basis of the clinical features of our patient and the late replication of the large amplified region, we searched for functional modifications in the adjacent Prader-Willi syndrome region.

Adolescent↗
PubMed1995

Utilization of neural network in the elaboration of an evaluation scale for pain in cerebral palsy.

An interesting aspect of neural networks is shown in the elaboration of an evaluation scale for pain in cerebral palsy with severe mental retardation. Because of the diversity of cases, the number of items had to be limited in the final step of statistical validation. Classical analysis on prior data did not allow to decide whether the variability in results is more likely due to the type of disability (i.e., the possibility of pain expression) than to the actual presence of pain. A neural network was used to find implicit relations between the data, with the advantage of having total control on the variables' status by applying variations in the network architecture. This allowed for the rapid identification more significant item combinations as a function of degree of relationship to pain in cerebral palsy.

Adolescent↗
PubMed1989

How well are endoscopes cleaned and disinfected between patients?

A questionnaire was sent to 276 hospitals throughout Australia to obtain details on the methods that are used in these institutions for the cleaning and disinfection of endoscopes. A broad range of hospitals was surveyed and 145 responses were received. Endoscopies were performed in 123 of the responding hospitals. Only 45% (55/123) of these hospitals both cleaned and disinfected their endoscopes satisfactorily. Generally, such hospitals were larger (300-600 beds) than were those which did not do so (100-300 beds) and also they were busier as more endoscopies were performed on a weekly basis (30.2 endoscopies compared with 19.3 endoscopies, respectively). Frequently (38% [47/123] of hospitals), the endoscopes were not disinfected between patients, or were disinfected for an insufficient time or were disinfected with an agent that did not have both antiviral and antibacterial activity. In a substantial proportion (40% [49/123]) of hospitals, endoscopes and their accessories appeared to be cleaned inadequately between patients. We conclude that in the majority of hospitals where endoscopies are performed that responded to our survey, there was considerable room for improvement in the cleaning and disinfection of endoscopes.

Disinfection↗
PubMed1989

Streptococcus faecalis arthritis.

Septic arthritis due to Streptococcus faecalis is rare. We describe a case in which synovial biopsy was required for diagnosis and a new longterm antibiotic combination using ciprofloxacin and amoxicillin was successful in treating the infection. Comparison is made with previous reported cases and the usual poor outcome in this condition.

Amoxicillin↗
PubMed1988

Sepsis associated with central vein catheters in critically ill patients.

In 440 critically ill patients, the association between different central vein catheter insertion sites, the duration of catheter insertion and catheter-associated sepsis was examined. Of 780 catheter tips studied, 19% were colonized by microorganisms. The incidence of colonization varied with the different insertion sites. The lowest percentage of colonized catheters occurred with catheters inserted via the subclavian vein (15%) and the highest, at the femoral vein insertion site (34%, p less than 0.01). The percentage of catheters colonized increased as the duration of insertion increased, at all insertion sites studied. Catheter colonization was closely related to the development of bacteraemia and was associated with approximately 10% of colonized catheters. Our results suggest that the subclavian site is associated with the lowest infective complication rate. To minimize catheter associated sepsis, catheters at all insertion sites should be used with parsimony and only kept in place for the minimum amount of time that their continuing use is necessary.

Catheterization, Central Venous↗