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Biomedical subjects

P Collignon

Publications and source records attributed to P Collignon.

At least 19 recordsLinked to original sources

How well are endoscopes cleaned and disinfected between patients?

A questionnaire was sent to 276 hospitals throughout Australia to obtain details on the methods that are used in these institutions for the cleaning and disinfection of endoscopes. A broad range of hospitals was surveyed and 145 responses were received. Endoscopies were performed in 123 of the responding hospitals. Only 45% (55/123) of these hospitals both cleaned and disinfected their endoscopes satisfactorily. Generally, such hospitals were larger (300-600 beds) than were those which did not do so (100-300 beds) and also they were busier as more endoscopies were performed on a weekly basis (30.2 endoscopies compared with 19.3 endoscopies, respectively). Frequently (38% [47/123] of hospitals), the endoscopes were not disinfected between patients, or were disinfected for an insufficient time or were disinfected with an agent that did not have both antiviral and antibacterial activity. In a substantial proportion (40% [49/123]) of hospitals, endoscopes and their accessories appeared to be cleaned inadequately between patients. We conclude that in the majority of hospitals where endoscopies are performed that responded to our survey, there was considerable room for improvement in the cleaning and disinfection of endoscopes.

Disinfection

Streptococcus faecalis arthritis.

Septic arthritis due to Streptococcus faecalis is rare. We describe a case in which synovial biopsy was required for diagnosis and a new longterm antibiotic combination using ciprofloxacin and amoxicillin was successful in treating the infection. Comparison is made with previous reported cases and the usual poor outcome in this condition.

Amoxicillin

Sepsis associated with central vein catheters in critically ill patients.

In 440 critically ill patients, the association between different central vein catheter insertion sites, the duration of catheter insertion and catheter-associated sepsis was examined. Of 780 catheter tips studied, 19% were colonized by microorganisms. The incidence of colonization varied with the different insertion sites. The lowest percentage of colonized catheters occurred with catheters inserted via the subclavian vein (15%) and the highest, at the femoral vein insertion site (34%, p less than 0.01). The percentage of catheters colonized increased as the duration of insertion increased, at all insertion sites studied. Catheter colonization was closely related to the development of bacteraemia and was associated with approximately 10% of colonized catheters. Our results suggest that the subclavian site is associated with the lowest infective complication rate. To minimize catheter associated sepsis, catheters at all insertion sites should be used with parsimony and only kept in place for the minimum amount of time that their continuing use is necessary.

Catheterization, Central Venous

Are anaerobic bacteria involved in peripheral vein catheter associated thrombophlebitis?

While thrombophlebitis is a common complication of intravenous therapy, infection has been shown to be a cause of this problem in only a minority of cases. However, the methodology employed in the past would not have detected the anaerobes as a cause of this problem. As anaerobes are associated with thrombophlebitis in situations such as septic pelvic thrombophlebitis, we undertook a study to see if they might also be involved in thrombophlebitis associated with peripheral vein catheters. We prospectively studied 26 episodes of peripheral intravenous catheter associated thrombophlebitis. These catheters were all cultured under aerobic conditions by the semiquantitative technique on blood agar plates. In addition, they were promptly processed and cultured under optimal anaerobic conditions. In none of the episodes of thrombophlebitis were the catheters positive on semiquantitative culture. In addition, we did not show the presence of anaerobes on any of these catheters. We conclude that there is no evidence that anaerobes are associated with peripheral vein thrombophlebitis.

Bacteria, Anaerobic

Localised form of spondylo-epiphyseal dysplasia congenita.

We report an unusual case of spondylo-epiphyseal dysplasia congenita which affected only the hips and the thoraco-lumbar spine. The epiphysis of the long bones are normal apart from the hips. Our child has a bilateral epiphyseal dysplasia of both proximal femoral epiphysis discovered incidentally at 11 months and confirmed later on at 8 years, associated with abnormalities of the superior margin of the vertebral bodies from T11 to L2. Very few similar cases have been reported anteriorly.

Child