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Biomedical subjects

P Chiewsilp

Publications and source records attributed to P Chiewsilp.

At least 91 records · Page 5Linked to original sources
PubMed1983

High prevalence of HLA-All in Thai seronegative spondyloarthropathies.

Forty-three patients with an established diagnosis of seronegative spondyloarthropathies (SNSA) were studied. There was an increase in the prevalence of HLA-All and HLA-B27 compared to controls. Twenty-nine of 43 patients (67%) studied had HLA-All and 29 also had B27 compared to 30.4% and 5.1%, respectively, in the controls (p less than 0.001 and less than 0.0001, respectively). The occurrence of HLA-B27 and HLA-All phenotype was not significantly associated in either the patient or the control groups (p greater than 0.75). These observations strengthen the hypothesis that genetic determinants in addition to HLA-B27 are of importance in the pathogenesis of SNSA.

Female↗
PubMed1981

Histocompatibility antigens and dengue hemorrhagic fever.

Histocompatibility antigen (HLA) A and B typing on lymphocytes from 87 unrelated Thai children who had been hospitalized with dengue shock syndrome (DSS) and/or dengue hemorrhagic fever (DHF) was compared with that found in 138 controls who had not been hospitalized with clinical dengue infection. These data are presented as descriptive information; however, a statistical analysis was performed to identify potentially important relationships for future study. Several deviations (P less than 0.05) were detected in the distribution of four HLA-A and three HLA-B antigens. The prevalence of one HLA-A antigen and two HLA-B antigens appeared to relate to the development of DSS, with a positive association seen for HLA-A2 and HLA-B blank and a negative relationship for HLA-B13. These findings require confirmation, but they do suggest that genetic susceptibility may be important in the development of DHF/DSS and indicate that further broader studies of genetic markers might be rewarding.

Child↗
PubMed1979

The HLA antigens and leprosy in Thailand.

HLA-A and -B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. There were no statistically significant deviations from expected antigen distribution in patients with any of the various forms of leprosy, though the number of patients studied is relatively small. There were some interesting trends, particularly a possible decrease in the number of tuberculoid patients with A9, and an increase in the proportions of lepromatous patients with B18 and B40. Limited evidence of a genetically controlled pre-disposition to the clinical manifestations of leprosy suggests that further studies with extended typing should be carried out on the HLA haplotype segregation in informative leprosy families. These should provide a clearer indication of the relevance of the HLA (including DR) and possibly of other non-HLA loci to the possible mechanism(s) of disease susceptibility.

Adolescent↗
PubMed1978

Red cell ABH antigens in leukaemias and lymphomas.

The qualitative and quantitative determinations of A, B, and H antigens were studied in blood samples of 509 normal subjects and 114 patients. 11 of 53 (20.75%), 3 of 27 (11.11%), and 4 of 34 (11.76%) of adults with leukaemia, children with leukaemia and adults with lymphomas, respectively, show significantly lower antigenic scores than normal controls. Since all A, B and H antigens were found to be independently affected, the destruction of well-developed ABH antigens by a certain substance produced during the course of the disease was suspected.

ABO Blood-Group System↗
PubMed1976

The HL-A system in Thais.

The HL-A antigens were studied in 100 Thai subjects. HL-A2, 11 and 9 of the first series and W15, HL-A17, 5, and 13 of the second series were commonly found. HL-A2-11 and W15- were the commonest phenotypes observed in the first and the second series, respectively. The HL-A2, X2, and 2, W15 were the most common haplotypes. However, there was no significant gametic association.

Asian People↗