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Biomedical subjects

P Chiewsilp

Publications and source records attributed to P Chiewsilp.

At least 73 records · Page 4Linked to original sources
PubMed1991

Diffuse systemic sclerosis and related diseases in Thailand.

Diffuse systemic sclerosis and the related syndromes were diagnosed in 115 patients during 1977-1987. Sixty-nine patients were available for clinical evaluation and analysis. These included 46 patients with diffuse systemic sclerosis, 2 with limited cutaneous systemic sclerosis, 2 with linear scleroderma, 18 with overlap syndrome (OS), and one with primary Raynaud's disease. The major clinical manifestations among the diffuse scleroderma patients were the involvement of the following systems; cutaneous (93.3%), musculoskeletal (69.6%), gastrointestinal (54.3%), and pulmonary (43.3%) while renal involvement (4.3%) was less common. Antinuclear antibodies were found in 89.7% with predominating speckle pattern (86.2%) and anti Scl 70 antibody (40.6%). In contrast to the Western series, HLA-DR2 was significantly increased in our diffuse systemic sclerosis patients (p less than 0.01). Among the 18 OS patients, the involvement of pulmonary system (44.4%) was the major cause of morbidity and renal involvement (55.6%) was found frequently although it was clinically mild. In conclusion, our diffuse systemic sclerosis and related diseases patients seem to have milder clinical manifestations than those of the Western series.

Adult↗
PubMed1990

Prevention of hepatitis B infection in infants born to hepatitis B carrier mothers: low dosage vaccination.

Two groups of newborn infants born to HBeAg positive carrier mothers were given HBIG (200 IU) immediately after birth. Subsequently, at age 2 days and at 1, 2 and 12 months, the first group received 5 microgram and the second group 2 microgram of HBV vaccines. There was no significant difference in the anti-HBs seroconversion rate (SR), and the protective efficacy rate (PER) at the age of 13 months in either group. The SR and PER of group 1 were 91.7% and 90.18%, and group II were 92.9% and 91.01%, respectively. Although the significant differences were observed in the geometric mean titers of anti-HBs in group I (526.3 mIU/ml) and group II (371.4 mIU/ml), both were above the protective level. The immune responses to the reduced dosage of HBV vaccines are satisfactory in preventing HBV in the newborn infants of HBeAg positive carrier mothers.

Female↗
PubMed1989

Long-term immunoprophylaxis of hepatitis B surface antigen carrier in infants born to hepatitis B surface antigen positive mothers using plasma derived vaccine.

Immunoprophylaxis of HBV infection using 3 doses (10 micrograms) of plasma derived HBV vaccine were given to 49 newborn infants of e-antigen negative HBs Ag carrier mothers at birth, one and 6 months of age. The protective efficacy rate was 100% during first 2 years. At 3 years of age, HBs Ag carrier was 2.63% and 89.48% of infants had anti-HBs above the protective level. Ten point fifty-two percent of total infants had anti-HBs level below 10 mIU/ml and 21.05% had anti-HBs level between 10-100 mIU/ml. Most infants who had the maximal level of antibody below 100 mIU/ml had lost all antibody within 3 years. The loss of antibody was closely related to the maximal anti-HBs titer (one year of age) which is highly predictive indicator of the longevity of anti-HBs.

Antibodies, Viral↗
PubMed1988

Red cell antibodies in thalassemia hemoglobinopathy patients.

One hundred sixty-four previously transfused patients with T/H disease received one to 136 transfusions with an average of 14.65. Immunization to red blood cell occurred in 14 patients (8.5%). Among these, 11 patients had alloantibody, one patient had autoimmune antibody, and two patients had both alloantibody and autoimmune antibody. The naturally occurring antibody (anti-Leb) was observed in pretransfused blood samples of two patients (1.2%). Most red cell immunization seemed to occur in the early period of blood transfusion.

Child, Preschool↗
PubMed1985

Autoimmune hemolytic anemia due to anti B autoantibody.

An anti B autoantibody was found during a routine cross-matching of the blood of two patients who presented with fever and hemolytic anemia. It appeared transiently and was shown to be IgM- and cold-reacting. The patients had an excellent response to a short course of corticosteroid treatment.

ABO Blood-Group System↗
PubMed1985

Immunoglobulins in leprosy.

Serum immunoglobulins were estimated by the single radial immunodiffusion technique and the results were compared among various groups of leprosy patients. Most of the serum immunoglobulin classes are increased in lepromatous leprosy patients. Controls from different regions in Thailand and even from two populations in the same region show different results. This can lead to different interpretations of results in leprosy patients and may explain apparent discrepancies in earlier studies of serum immunoglobulins in leprosy.

Adolescent↗