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Biomedical subjects

P Charpentier

Publications and source records attributed to P Charpentier.

69 records · Page 4Linked to original sources
PubMed1982

Gastric carcinoma with argyrophilic cells: light microscopic, electron microscopic, and immunochemical study.

An immunochemical study of a gastric adenocarcinoma with argyrophilic cells showed two areas of tumor that react differently with the usual histochemical reagents as well as with immune sera against gastrin and mucoprotein associated with antigens. Ninety per cent of the tumor cells were PAS positive and contained M2 antigen, and some also contained M1 antigen. About 30 per cent of the M2-positive cells stained strongly with an antigastrin serum as well as with the argyrophilic reagents. The remaining 10 per cent of tumor cells were signet-ring cells located in several clumps in the tumor. These cells were positive for both PAS and alcian blue and contained intestinal M3 antigen. Forty-five per cent of them also contained M1 gastric antigens. Carcinoembryonic antigen (CEA) was found in the cytoplasm of each tumor cell. The presence of CEA and M1 antigen together indicates a fetal pattern, suggesting that the cells originate from very immature gastrointestinal stem cells.

Adenocarcinoma↗
PubMed1980

[Post-radiation injury of the ileal small bowel: clinical and pathological report of 12 cases (author's transl)].

At the Institut Gustave-Roussy we have collected a series of 12 cases studied both on clinical and patological grounds. These patients underwent ileal resection for acute abdominal symptoms occuring after radiation therapy for genital cancer. Ileal lesions after radiation of gynecological cancer are rare: one per cent at the Institut Gustave-Roussy. These complications occur when certain technical types of radiation therapy are employed, and especially when dose exceeds 50 Gy or when a particular clinical condition is present. Gross examination of the bowel segment shows a stiffness of the digestive wall with frequent stenosis, sometimes in association with perforation or fistula. Histological lesions of radiated bowel are essentially located in the submucosa. They are nonspecific, mainly represented by obliterative angiopathy and fibrosis of the ileal wall.

Adult↗
PubMedDate not supplied

Is there a typical pattern of brain SPECT imaging in Alzheimer's disease?

The identification of new nosological forms such as Lewy body disease (LBD) requires a re-evaluation of the patterns observed in brain functional imaging in the various forms of dementia. We studied 60 demented patients, divided into three groups and fulfilling the clinical criteria for Alzheimer's disease (AD), LBD and frontotemporal dementia (FTD), using Tc-HMPAO and a brain-dedicated SPECT system. After normalisation we applied a cut-off at two levels according to previously established criteria. We reaffirmed the already established data concerning FTD (mainly a bilateral frontal decrease) and for LBD (a severe diffuse decrease in the frontal regions and also in the posterior association cortex). In contrast, the decrease in AD was strictly limited to the parieto-occipital cortex, irrespective of the severity of the cognitive decline. We hypothesise that the major simplification concerning the pattern observed in AD can be explained by the fact that patients suffering from LBD have previously been included in the groups of AD patients.

Aged↗
PubMedDate not supplied

The benefits of using the International Classification of Impairments, Disabilities, and Handicaps in rehabilitation: a survey of 950 cases.

The case dossiers of 950 patients attending a rehabilitation centre were reviewed to permit appraisal of the value of the ICIDH for monitoring changes in disablement status under treatment. The approach was valuable for identifying people in need of rehabilitation services and for evaluating the care dispensed to such individuals. Certain problems in application of the ICIDH in practice are noted.

Adult↗
PubMedDate not supplied

Fine needle aspiration of the liver and pancreas with ultrasound guidance.

The experience of the Institut Gustave-Roussy in the diagnosis of hepatic and pancreatic lesions by fine needle aspiration (FNA) is reported. Totals of 116 consecutive percutaneous ultrasound-guided FNAs of the liver and 27 of the pancreas were performed without complication in patients with ultrasonically suspected neoplastic lesions. In 12 cases, the material was not suitable for diagnosis. In the liver, 97 cases were correctly diagnosed and confirmed by follow-up. Immunohistologic studies were helpful in distinguishing primary liver tumors from other malignancies. One false-positive result was reported. In the pancreas, malignancy was detected in 17 cases. Cytology alone provided the correct tumor diagnosis in 15 cases: 10 primary carcinomas, 2 endocrine tumors and 3 metastases. The sensitivities of FNA in this study were 87.6% for the liver and 85% for the pancreas, similar to those reported in other series.

Biopsy, Needle↗
PubMedDate not supplied

[Epidemiology of intestinal helminthiasis (necatoriasis, taeniasis, ascariasis, trichuriasis) in the Kaya Region (Upper-Volta)].

Prevalence of intestinal helminthiasis: 1 223 stool specimens are examined in Louda and 690 in Damesma (Kaya, Upper-Volta). In this sample eggs of N. americanus are seen in 14,7% of the specimens in Louda and 9,3% in Damesma. Eggs of H. nana are seen in 10% of the specimens, for the two villages. Eggs of T. saginata are seen in 7.4% of the specimens of the two villages. And eggs of A. lumbricoides, T. trichicera are found inters then 0.5% of the specimens.

Adolescent↗