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Biomedical subjects

P Chapman

Publications and source records attributed to P Chapman.

At least 91 records · Page 5Linked to original sources
PubMed1982

Prevalence of cervical neoplasia and infection in women using intrauterine contraceptive devices.

Consecutive cervical smears examined in 1980 were divided into those from women using intrauterine contraceptive devices (IUDs) (757) and those not using them (11,711). Actinomycetes were not found in the non-IUD group but were present in 7.0% of the IUD group and were significantly more common in women with plastic IUDs (11.7%) than in those with copper ones (2.1%). Cervical intraepithelial neoplasia (CIN), grade 3, was significantly more common in the IUD group (1.06%) than in the non-IUD group (0.34%). Trichomonas infection was significantly more common in women with IUDs and actinomycetes (9.4%), in those with IUDs and without actinomycetes (1.6%) and in those without IUDs attending the clinic for sexually transmitted disease (STD) (5.9%) than in non-IUD, non-STD women (0.7%). Candida infection was not more common in women with IUDs (with or without actinomycetes) (1.2%) than in non-IUD, non-STD women (2.1%) but was significantly more common in STD women (3.8%). A repeat study in 1981 showed a similar prevalence of CIN 3: 1.03% of the IUD group (485) and 0.33% of the non-IUD group (10,850).

Actinomycetales Infections↗
PubMed1981

The diagnosis and surgical management of olfactory neuroblastoma: the role of craniofacial resection.

The diagnosis and clinical management of olfactory neuroblastoma are discussed. Computerized tomography is a valuable means of assessing the pre-operative extent of disease and the efficacy of subsequent major surgery. The tissue diagnosis is facilitated by electron microscopy, demonstrating the presence of dense core vesicles and cytoplasmic filaments. Radiotherapy followed by craniofacial resection is the treatment of choice for olfactory neuroblastomas that are locally extensive at presentation.

Adolescent↗
PubMed1980

Endodermal sinus tumor of the pineal region.

Two cases of endodermal sinus tumor of the pineal region are reported and compared with 16 others in the literature. The preponderance of neoplasms occurs in boys, usually in their second decade. The diagnosis is usually established within three months of the onset of non-specific symptoms of an intracranial mass. Treatment with operation or radiotherapy alone is inadequate. Most patients have died within two years, some with widespread intradural metastases. The one individual who has survived five years was treated with both operation and radiotherapy.

Adolescent↗
PubMed1980

The role of computed tomography in tumours of the larynx.

A clinical study of computed tomography (CT) was undertaken in 35 patients with tumours involving the larynx. Twenty-seven had primary laryngeal neoplasms, five had tumours arising in adjacent structures but invading the larynx and three who had undergone total laryngectomy were investigated for possible recurrence. The findings were compared with conventional radiological methods and clinical assessment. Confirmation was obtained from laryngectomy specimens in four patients and at autopsy in one. CT provided additional preoperative information on 14 occasions. This included better delineation of submucosal tumour extent, invasion of the pre-epiglottic space and cartilage displacement in invasion.

Humans↗
PubMed1980

Mastoid chloroma as relapse in acute myeloid leukaemia.

Leukaemic infiltration of the petrous temporal bone is uncommon with with improved remission rates and longer survival in leukaemia isolated sites of relapse can be expected more frequently. Mastoid chloroma requires treatment with chemotherapy and radiotherapy. Wide-field mastoidectomy and facial nerve decompression are contraindicated.

Adult↗