The accumulation of 5alpha-dihydrotesterone (5alpha-DHT) by human breast tissue.
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Biomedical subjects
Publications and source records attributed to P Carson.
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A patient with long-standing seropositive erosive rheumatoid arthritis developed a pericardial effusion with chronic cardiac tamponade. He had evidence of conducting system disease and developed heart block. He was successfully treated by pericardiectomy and implantation of a demand pacemaker.
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The electromechanical interval (EMI) was measured in 25 normal males, 56 male patients with a myocardial infarction and 6 patients with a ventricular aneurysm. In the normal subjects the EMI was found to be unrelated to the heart rate but the isovolumic contraction time was inversely related to the heart rate. The EMI was increased after myocardial infarction but this increase did not occur in patientswho had a non-transmural infarction when they had not had any previous myocardial infarction. The increase was more marked in the patients with a ventricular aneurysm. It is suggested that the prolongation of EMI is due to areas of abnormal left ventricular wall movement and that this effect may be a useful aid to the diagnosis of ventricular aneurysm.
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Electrocardiograms were recorded from human patients using a bipolar chest lead together with simultaneous His-bundle electrograms. These were then subjected to the technique of signal averaging in an attempt to extract His-bundle activity from the surface record. This was successful in three out of 10 cases subjected to the truly non-invasive surface technique. Methods are discussed by which the technique could be improved.
A case of complete interruption of the aortic arch in an adult is presented and the previous 8 reported cases are reviewed. Obliteration of the ductus is a feature of these cases, in contrast to the more common variety found in early childhood. Comments are made on the clinical distinction between the adult type of complete interruption of the aortic arch and coarctation of the aorta.
STI were measured on the 7th day after acute myocardial infarction in 144 male patients. These patients were reviewed at 6 weeks and 86 were reinvestigated and reviewed at 6 months. The STI could not predict the patients who would have either angina or a further myocardial infarction. Left ventricular function, as measured by STI, appeared to be a minor factor governing return to work after myocardial infarction. Patients who had developed ventricular aneurysms at 6 months had significantly increased EMI at 6 weeks. STI on day 7 had considerable prognostic significance for left ventricular failure at 6 weeks and death between day 7 and 6 weeks and it is suggested that LVET index could be usefully, and easily, introduced as a parameter after myocardial infarction.
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Fifty-nine men with known coronary disease entered an exercise rehabilitation programme. Forty-nine had sustained recent myocardial infarctions, nine had had past myocardial infarcts, and one had had a recent internal mammary implant for severe angina. Each class lasted about 45 minutes and they were held twice weekly; the course for each patient was three months. Sixteen patients dropped out from the course, only three for reasons obviously medical. No deaths or cardiac arrests occurred during the programme. Extrasystoles and angina were detected in a minority of patients and did not constitute reasons for failure to complete the course. The main aim of the study was to show that such a programme is feasible in a district general hospital. Improvement in the morale of patients was impressive and the incidence of return to work high.