Ninety adult leprosy patients attending the skin outpatient department of Institute Hospital of Varanasi, India, were selected for the study. A group of thirty patients including 10 cases of lepromatous, 10 of borderline and 10 cases in reaction of which 5 were of type 1 and 5 of type II reaction were treated with levamisole and DDS. Levamisole was given in the doses of 150 mg. daily for three consecutive days which was repeated after every 12 days. The effects were compared with two similar groups receiving clofazimine plus DDS and DDS alone respectively for six months. It was observed that levamisole was useful in bringing down both the types of reactions in a period shorter than required by clofazimine. Clinical improvement in non-reaction cases was found to be similar in all the three groups. Minor side effects were also seen with levamisole and clofazimine in some cases.

Clofazimine↗

PubMedDate not supplied

Immuno-stimulatory effect of levamisole in borderline leprosy cases.

Eleven cases of borderline-borderline leprosy were subjected to levamisole therapy for 3 months. Levamisole was given 150 mg/day on three consecutive days every fortnight along with dapsone (DDS). Immuno-stimulation was assessed by lepromin test using Lepromin-A supplied by W.H.O. containing 4.0 X 10(7) bacilli per milli litre. It was found that there was statistically significant change in lepromin reaction after levamisole therapy.

Adjuvants, Immunologic↗

PubMedDate not supplied

Levamisole in cases of E.N.L.

Levamisole, the anthelmintic drug was tried in ENL (Erythema Nodosum Leprosum) cases using double blind control trial in dosage of 150 mg/day on three consecutive days for three months. It was found that levamisole was not effective in ENL cases and no severe side effect was seen in these cases.

Adolescent↗

PubMedDate not supplied

A study on the pattern of sickness amongst residents of Chetla, Calcutta belonging to low socio economic status.

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Adolescent↗

PubMedDate not supplied

Giardiasis in adults. Studies on jejunum and immunoglobulins.

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Adult↗

PubMedDate not supplied

Differential effect of bone marrow protein on brain ATPase of immunized control and malnourished rats.

After sheep erythrocyte (SRBC) immunization in balanced-diet-fed (BDF) rats, the brain microsomal ATPase activity for the first 48 h was suppressed compared with preimmunization level, then stimulated at the peak of the immune response. In contrast, rats malnourished by deprivation of vitamin B complex and ascorbic acid and with significantly lower pre- and postimmunization enzyme activity than the BDF rats, had stimulated enzyme activity only on immunization, and their immune response was found to be suppressed. A bone marrow-derived bioimmunomodulator (BIM) revived the immunocompetence of the malnourished immunized animals, and brain ATPase activity in these animals after BIM injection followed a pattern similar to that of the immunized BDF rats. We suggest that, after SRBC immunization under the influence of BIM, suppression followed by stimulation of the brain microsomal ATPase might be related to immune response.

Adenosine Triphosphatases↗