Search PubMed⌕ Search

Biomedical subjects

P Bloom

Publications and source records attributed to P Bloom.

At least 19 recordsLinked to original sources
PubMed1999

The perceived intentionality of groups.

Heider and Simmel [Heider, F., Simmel, M., 1944. An experimental study of apparent behavior. American Journal of Psychology 57, 243-259] found that people spontaneously describe depictions of simple moving objects in terms of purposeful and intentional action. Not all intentional beings are objects, however, and people often attribute purposeful activity to non-object individuals such as countries, basketball teams, and families. This raises the question of whether the same effect found by Heider and Simmel would hold for non-object individuals such as groups. We replicate and extend the original study, using both objects and groups as stimuli, and introducing two control conditions with groups that are not engaged in structured movement. We found that under the condition that best promoted the attribution of intentionality, moving groups are viewed as purposeful and goal-directed entities to the same extent that moving objects are. These results suggest that the psychological distinction between the notion of 'intentional entity' and the notion of 'object' can be found even in the perception of moving geometrical figures.

Adult↗
PubMed1999

Is grammar special?

Recent studies of children with developmental disorders provide striking insights into the nature of language. These studies suggest that, although much of language arises from more general cognitive capacities, certain aspects of grammar have an autonomous psychological and neural basis.

Child↗
PubMed1999

Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload.

BACKGROUND: Circulating iron is normally bound to transferrin. Non-transferrin-bound iron (NTBI) has been described in most forms of iron overload, but has not been studied in African dietary iron overload. This abnormal iron fraction is probably toxic, but this has not been demonstrated. METHODS: High-pressure liquid chromatography was used to assay serum NTBI in 25 black African subjects with iron overload documented by liver biopsy and in 170 relatives and neighbours. Levels of NTBI were correlated with indirect measures of iron status and conventional liver function tests. RESULTS: Non-transferrin-bound iron (> 2 micromol/L) was present in 43 people, 22 of patients of whom underwent liver biopsy and 21 relatives and neighbours. All but four of these had evidence of iron overload on the basis of either liver biopsy or elevated transferrin and serum ferritin concentrations. Among all 195 subjects, the presence of NTBI in serum was independently related to elevations in alanine and aspartate aminotransferase activity and bilirubin concentration. This relationship between serum NTBI and hepatic dysfunction was confirmed in the subgroup of 25 subjects with iron overload documented by liver biopsy. Non-transferrin-bound iron correlated significantly with elevations in alanine and aspartate aminotransferase activities after adjustment for hepatic iron grades, inflammation and diet. CONCLUSIONS: Non-transferrin-bound iron was found to be commonly present in African patients with dietary iron overload and to correlate with transferrin saturation and serum ferritin concentration. The independent relationship between NTBI and elevated liver function tests suggests that it may be part of a pathway leading to hepatic injury.

Aspartate Aminotransferases↗
PubMed1998

Evidence of genetic transmission in African iron overload.

Iron overload in Africa was previously regarded as purely due to excessive iron in traditional beer, but we recently found evidence that transferrin saturation and unsaturated iron binding capacity may be influenced by an interaction between dietary iron content and a gene distinct from any HLA-linked locus. To determine if serum ferritin follows a genetic pattern and to confirm our previous observations, we studied an additional 351 Zimbabweans and South Africans from 45 families ranging in size from two to 54 members. Iron status was characterized with repeated morning measurements of serum ferritin, transferrin saturation, and unsaturated iron binding capacity after supplementation with vitamin C. For each measure of iron status, segregation analysis was consistent with an interaction between a postulated iron-loading gene and dietary iron content (P < .01). In the most likely model, transferrin saturation is 75% and serum ferritin is 985 micrograms/L in a 40-year-old male heterozygote with an estimated beer consumption of 10,000 L, whereas the saturation is 36% and serum ferritin is 233 micrograms/L in an unaffected individual with identical age, sex, and beer consumption. This segregation analysis provides further evidence for a genetic influence on iron overload in Africans.

Adult↗
PubMed1997

Evidence against a dedicated system for word learning in children.

Children can learn aspects of the meaning of a new word on the basis of only a few incidental exposures and can retain this knowledge for a long period-a process dubbed 'fast mapping". It is often maintained that fast mapping is the result of a dedicated language mechanism, but it is possible that this same capacity might apply in domains other than language learning. Here we present two experiments in which three- and four-year-old children and adults were taught a novel name and a novel fact about an object, and were tested on their retention immediately, after a 1-week delay or after a 1-month delay. Our findings show that fast mapping is not limited to word learning, suggesting that the capacity to learn and retain new words is the result of learning and memory abilities that are not specific to language.

Adult↗
PubMed1997

Linguistic cues in the acquisition of number words.

Previous research has shown that children go through a stage in which they know that the number words each refer to a distinct numerosity, yet do not know WHICH numerosity each number word picks out (Wynn, 1992). How do children attain this level of knowledge? We explore the possibility that particular properties of how number words are used within sentences inform children of the semantic class to which they belong. An analysis of transcripts of the spontaneous speech of three one- and two-year-old children and their parents (from the CHILDES database; MacWhinney & Snow, 1990) suggests that the relevant cues are available as input in parents' speech to children, and that children generally honour these properties of number words in their own speech. Implications of this proposal for word learning more generally are discussed.

Child Language↗
PubMed1997

Fellowship training.

Explore the source record for details and available documents.

Fellowships and Scholarships↗
PubMed1997

Trabeculectomy with intraoperative sponge 5-fluorouracil in Afro-Caribbeans.

AIM: To study the efficacy and safety of intraoperative 5-fluorouracil (5-FU) in Afro-Caribbean patients. METHODS: The results of trabeculectomy in 18 eyes of 18 Afro-Caribbean patients in whom a sponge soaked in 25 mg/ml solution of 5-FU was applied between Tenon's capsule and sclera for 5 minutes before excision of the trabecula were compared with 16 eyes of 16 Afro-Caribbean patients matched for age, quantity, and duration of preoperative medications, who underwent trabeculectomy without 5-FU. RESULTS: The mean postoperative intraocular pressure (IOP) at 1 month was 15.6 (SD 6.1) mm Hg in the 5-FU group and 18.0 (5.2) mm Hg in the control group (p = 0.15). There was no significant difference in the IOP at 6, 12, 15, 18, and 24 months in the two groups. Success rate at 18 months defined as an IOP less than or equal to 21 mm Hg with no adjunctive medication was 56% in the 5-FU group and 55% in the control group. No major complications were noted in either group. CONCLUSION: Intraoperative sponge 5-FU alone is safe but does not appear to decrease the risk of failure of trabeculectomy in Afro-Caribbeans.

Administration, Topical↗