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Biomedical subjects

P Binder

Publications and source records attributed to P Binder.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Study of the transfer of immunostimulation from the mother to the young mouse using 2 immunostimulants and the PFC test].

Pregnant Mice were stimulated with two substances, an antibronchitic lysate (LAB) and diethyldithiocarbamate (DTC). PFC response was studied in mothers and their offspring for 6 weeks after birth. An increase in PFC response was noted in the immunostimulated adult Mice. In the newborn Mice, the number of PFC increased between the 1st and 6th week. In comparison with controls, PFC response appeared later in the newborns to LAB-stimulated mothers and earlier in those to DTC-stimulated mothers.

Adjuvants, Immunologic↗
PubMed1982

[Comparative study of various routes of vaccination and testing. An instance of a killed bacterial vaccine].

The efficiency of intranasal subcutaneous, aerosol and digestive vaccinations with killed Klebsiella pneumoniae as vaccine was studied on the survival curves after experimental disease with pathogen K. pneumoniae I inoculated by the same routes. Results show that the local immunization is an important factor of protection and the intranasal route is very convenient.

Administration, Intranasal↗
PubMed1982

OKT8 human phenotype expressed by Papio papio monkey lymphocytes.

The potential cross-reactivity between human and Papio papio monkey lymphocyte antigens was investigated using various monoclonal antibodies specific for human T cell subsets and HLA-DR antigens. Monkey circulating lymphocytes expressed the OKT8 antigen, specific for the suppressor/cytotoxic T cell population and the HTLA antigens. These reactivities were also detected on lymphoid cells in the thymus and lymph nodes of the Papio monkey.

Animals↗
PubMed1977

[Geophagia sideropenica].

The authors describe two cases of geophagia (45 years old mother and her 25 years old daughter). Both suffered from an anaemia of medium degree only (case 1: 3.77 million of erythrocytes, Hb 8.5 g%; case 2: 3.34 million of erythrocytes, Hb 10 g%), there was a serious iron deficiency (46 and 35 microgram % respectively of serum iron). Both were blood donors, the mother 7 times and the daughter 31 times. In both cases the iron deficiency existed before geophagia. The desire for eating argillacecous earth already disappeared after the application of some ampules of Ferrlecit injected intravenously, even before the values of the serum iron and the number of erythrocytes had changed. The number of erythrocytes, the Hb value and that of haematocrit as well as the values of the serum iron normalized completely. EEG changes were observed in both cases, which could be influenced by the ferrotherapy. The authors recommend the serum iron estimation in all blood donors as well as the introduction of their routine treatment with iron preparations.

Adult↗
PubMed1977

["In situ" anesthetics and experimental cryotumorectomy].

Some similarities have been found between the actions of anesthetics and freezing on biological membranes. Therefore, it has been thought that these agents could potentiate the destructive effect of cryosurgery. Experiments on cryopreservation of HeLa cells in vitro using three anesthetics--thiopental sodium, lignocaïne and CT 1341--indicate enhancement of "cryosensitivity". When using in vivo the same anesthetics injected in an experimental carcinoma (KDMC) of the Sprague-Dawley rat, cryosurgically treated, the results are: --no tumoricidal effect nor antitumoral activity of these agents when used alone,--the simultaneous use of anesthetics and cryosurgery gives better (but no significant results than cryosurgery alone,--the best agent in regard to this possible adjuvant effect seems to be thiopental sodium, it also facilitates tumoral dissemination. The authors conclude from these preliminary results that they need further experiments to assess this findings with smaller tumors, more numerous animals, same and others anesthetics at different concentrations. They attempt to define some caracteristics of potentiative agents during physical phase of cryodestruction.

Alfaxalone Alfadolone Mixture↗
PubMed1975

[Effect of intratumoral injection of bacterial and viral neuraminidase in rats].

We studied the effect of neuraminidase injection in rat's tumor at different doses: 5,10,50,100, 500 U and we concluded that: There was no difference between the rats treated with 5,10,50 U and the controls. The y died 3 weeks after the injection. But the rats treated by 100 at 500 U of NA died quickley, in the week, of long metastases.

Animals↗