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Biomedical subjects

P Bauer

Publications and source records attributed to P Bauer.

At least 199 records · Page 11Linked to original sources
PubMed1982

Effects of a combination of oral naproxen sodium and codeine on experimentally induced pain.

The effect of an orally administered combination of naproxen sodium 550 mg and codeine phosphate 60 mg on threshold and tolerance to electrically induced pain, and on the threshold to thermally induced pain, was compared with the effects of naproxen sodium 550 mg alone, codeine phosphate 60 mg alone, and placebo. 16 female and 16 male, healthy young subjects, took part in four experiments on consecutive days of one week. On each day one treatment was administered, in random order, under double blind conditions. The combination increased threshold and tolerance to electrically induced pain and the threshold thermally induced pain markedly more than did naproxen sodium alone. Naproxen sodium plus codeine was also more effective in increasing threshold and tolerance to electrically induced pain than was codeine alone; the latter increased the threshold and tolerance to electrically induced pain and the threshold to thermally induced pain markedly more than placebo. Naproxen sodium alone had a relatively weak effect on the three pain measures. Reaction time to acoustic stimuli and the side effect profile were not significantly influenced by any of the treatments, and no severe adverse effects occurred. It is concluded that the combination of naproxen sodium 550 mg and codeine phosphate 60 mg, as indicated by its effects on experimentally induced pain, can produce more intense analgesia than the same doses of naproxen sodium and codeine administered alone, and that naproxen sodium and codeine phosphate given in combination enhanced each other's effect in an additive manner.

Adult↗
PubMed1982

Effect of pirenzepine on meal-stimulated acid secretion and gastrin release in normal man.

The effect of increasing doses of pirenzepine, a tricyclic compound and new antiulcer drug, on meal-induced gastric acid secretion, gastrin release and gastric emptying of the liquid meal, was investigated in eight healthy volunteers. Gastric acid secretion was assessed using intragastric titration technique. Intra-muscularly administered doses of pirenzepine tested were 0 (placebo), 0.1, 0.25 and 0.5 mg.kg-1. With increasing doses of pirenzepine a dose-related reduction of meal-stimulated acid response was noticed amounting to 53% of control values with the highest dosage. The IC 50 value is close to 200 ng.ml-1. Initial but not total gastric emptying of the liquid protein-meal was slowed by 0.5 mg.kg-1 pirenzepine dose. Gastrin responses to the meal were reduced in a dose dependent manner although to a lesser degree.

Adult↗
PubMed1982

Dose-related effects of the synthetic met-enkephalin analogue FK 33-824 on esophageal motor activity in healthy humans.

The effects of FK 33-824, a methionine enkephalin analogue, 313, 625, 1250, 2500, and 5000 ng/kg body wt intramuscularly, on esophageal motor activity and cardiovascular and central nervous functions were studied in 8 healthy men. In the lower one-third of the esophagus, amplitude and duration of swallow contractions increased dose-dependently within 15 min after administration. In the middle one-third, amplitudes increased only slightly, whereas no systematic changes occurred in the upper one-third. The propagation velocity of the deglutitive wave accelerated dose-dependently between 15 and 10 cm as well as between 10 and 5 cm above the lower esophageal sphincter, the acceleration being more pronounced in the distal segment. Heart rate and systolic and diastolic blood pressure increased dose-relatedly, while no effects were found on electroencephalogram and reaction time. These results, together with earlier findings, support the notion of a participation of enkephalins in the regulation of the smooth muscle esophagus.

Adult↗
PubMed1981

[Chloramphenicol concentrations in serum and CSF in newborn infants and babies with bacterial meningitis (author's transl)].

Serum and CSF levels of chloramphenicol were determined repeatedly during the course of treatment in 24 premature and full term babies and infants with bacterial meningitis. Variations in chloramphenicol concentrations were caused in the premature babies by a small dose increase or by interaction with other drugs. In the fullterm newborn babies a higher dose could be given but even in these children the increase in concentration after small changes in dosage was marked. Chloramphenicol doses of 100 mg/kg daily could only be given after the sixth or eighth weeks of life. In the mature newborns and in the older babies inaccuracies in the administration of the drug may be a cause of marked variations of serum and CSF concentrations.

Chloramphenicol↗
PubMed1981

Intracellular crystal formation in bacteria from human urines: a contributing factor in urinary calculi.

Understanding of the bacterial contribution to urinary calculi has been limited to those organisms capable of altering the urine through urease activity. Sterilized urines from stone forming and non-stone forming individuals were inoculated with bacteria having either strong, weak, or no urease activity. All organisms grown in unbuffered urines produced crystallization (calcite or apatite) as demonstrated by X-ray diffraction. Bacteria grown in conventional medium (Heart Infusion broth) did not demonstrate crystal formation. Unstained specimens revealed electron-dense deposits within bacteria grown in urine. Deposits were not present in organisms grown in conventional media. Analysis revealed increased levels of calcium within these deposits as compared to extracellular levels. These findings support the hypothesis that both urease producing an non-urease producing organisms may accumulate calcium crystals intracellularly and form nidi for calculus formation.

Apatites↗
PubMed1981

[Effects of sporting activities on the psyche of elderly people (author's transl)].

During a 1 year long investigation, 93 50-70 year old male persons took part in a special sports program. The comparison between the first and the second investigation showed a success of the training for several psychological dimensions in direction of less depression and less aggression, as well as a greater emotional stability, although results of the first investigation showed no pathologic deviation of personality structure of the participants. Comparing three groups; (sportsmen, former sportsmen, and people who never did sports before) it could be demonstrated that members of all three groups showed positive results concerning their personal traits, so that a positive coherence between sporting activities and less depression and more emotional stability became statistically significant.

Adaptation, Psychological↗
PubMed1980

[Effects of drug interaction in infancy (author's transl)].

In numerous therapeutic regimens for infants it often happens that more than one drug is given. Most doctors however, do not know sufficiently if and to which extend an interaction between the different substances takes place in the human organism. Phenytoin in combination with other drugs (anticonvulsives, antibiotics etc.) demonstrates the many different mechanisms of interaction.

Carbamazepine↗
PubMed1980

Studies on Dipetalonema viteae (Filarioidea). 5. Ultrastructural aspects of the antibody-dependent cell-mediated destruction of microfilariae.

The antibody-dependent cell-mediated destruction of Dipetalonema viteae microfilariae was followed by electron microscopy both in vitro and within micropore chambers in vivo. There was a correlation between the degree of adherence (1% mf with adhered cells) and the degree of microfilarial damage. Polymorphonuclear leukocytes, predominantly neutrophils, seemed to be responsible for the destruction of microfilariae in vivo. An in vitro assay indicated that eosinophils also have a role as potent effectors against microfilariae. The first sign of microfilarial damage is the disintegration of cuticular layers. In a later stage of destruction, lysis of the hypodermis or even of the whole microfilarial tissues was observed.

Animals↗
PubMed1980

[A method for prediction of outcome in patients with critical abdominal diseases under artificial ventilation (author's transl)].

Patients critically ill from abdominal diseases under controlled ventilation showed statistically significant differences in some vital signs and measurements immediately after admission to the intensive care unit, when grouped according to survivors (34 patients) and nonsurvivors (40 patients). On the basis of a stepwise linear discriminant analysis a practicable method of prognosis from data of the first 24 hours could be achieved, which enables a correct prediction of outcome in 91% of the survivors and 79% of the nonsurvivors.

Gastrointestinal Diseases↗