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Biomedical subjects

P Arlet

Publications and source records attributed to P Arlet.

119 records · Page 7Linked to original sources
PubMedDate not supplied

[Bone and calcium metabolism in adult hypothyroidism (author's transl)].

A study of blood and urinary calcium and phosphorus, 25 hydroxyvitamin D plasma level (25 OH D3), bone radiology and hystology is performed in 12 hypothyroïd adult patients. This study confirms the notion of myxoedematous ostéopetrosis. Radiologic and histologic findings shows an osteocondensation, more important on the skull, and augmentation of cortical thickness of the bones is noted. Quantitative histologic findings, shows some signs of diminution of bone cellular activity. Low plasma level of 25 OH D3 in these patients is discussed in the view of an event of a disturb in the metabolism of D-vitamin in hypothyroïdism.

Adult↗
PubMedDate not supplied

[Low 25-hydroxy-vitamin D (25-OH-D) plasma levels in pathology (author's transl)].

Between october 1976 and march 1978, 160 patients with low 25-OH-D plasma levels were observed (25-OH-D less than 7 ng/ml). In this population, a high frequency of asthenia, anorexia, vertebral demineralization were noticed. Mean plasma level of calcium was significantly lower than controls. Mean plasma level of alkalin phosphatases was significantly higher than controls. These patients presented a varied pathology. These diseases were probably responsible for the low 25-OH-D plasma level. The mechanisms were varying, but anorexia and sun exposure defect were likely the main cause of the low 25-OH-D plasma level.

25-Hydroxyvitamin D 2↗
PubMedDate not supplied

[A medical investigation of 160 chronic alcoholic patients hospitalized in a department of internal medicine. Nature and pathological consequences of the intoxication (author's transl)].

160 hospitalized chronic alcoholics (124 men and 36 women) were evaluated by the same person. 21 biologic parameters were assessed. A histopathological examination of the liver was performed in 57.5% of the cases. The average daily alcohol consumption (ADAC) during the last five years exceeded 80 g in 140 patients. Results were as follows. Alcoholics usually have a poor socio-economic and professional background and a low educational level, most of them being farmers or workers. The ADAC is 170 g/day for an average duration of 32 +/- 3 years. The diet is unbalanced. The consumption of tobacco is related to age, sex and ADAC. There is no significant correlation between hepatic lesions (cirrhosis: 37 cases, alcoholic hepatitis without cirrhosis: 83 cases, normal liver: 36 cases) and age, sex, diet, ADAC, or the duration of intoxication. Pancreatic involvement was found in 13 patients (6.8%). Neuropsychiatric features were present in 92% of the patients. A significant correlation was found between stellar angiomas, clinical liver involvement, and ADAC, between palmar erythrosis, and clinical liver involvement and between hippocratism and ADAC. VMC and Gamma GT levels are significantly correlated to liver involvement and ADAC. There is a linear correlation between VMC and Gamma GT. The Gamma GT/BUN ratio is significantly correlated to ADAC. No correlation was found between serum vitamin B12, serum folic acid and VMC. No patient was HbS antigen-positive. Anti-HbS antibodies were found in 19.2% of the cases.

Adult↗
PubMedDate not supplied

[Prevalence of hypothyroidism and hyperthyroidism in temporal arteritis and rhizomelic pseudopolyarthritis. A controlled study of 104 cases].

The aim of this study was to assess the prevalence of hyperthyroidism and hypothyroidism in giant cell arteritis and polymyalgia rheumatica. The prevalence of thyroid dysfunction in giant cell arteritis and polymyalgia rheumatica patients was determined retrospectively from 1976 through 1984 and prospectively from 1984 through 1991. A control group was composed of patients over 55 years of age consecutively admitted to the same hospital department for another condition. Patients were screened for thyroid dysfunction using a thyrotropin assay. Abnormal results were evaluated by T3 and T4 assays and, if needed, a TRH test. Among the 68 giant cell arteritis patients (mean age 72.6 +/- 7 years), of which 41 were included in the prospective arm of the study, 6 had hypothyroidism and 3 had hyperthyroidism. Corresponding figures were 4 and 4 among the 36 patients with polymyalgia rheumatica (mean age 71.7 +/- 8.3 years), of which 18 were evaluated prospectively. Among the 305 controls (mean age 71.6 +/- 9.4 years), 16 had hypothyroidism and 10 had hyperthyroidism. Prevalences of hypothyroidism, hyperthyroidism, and antithyroid antibodies were not significantly different in the control and case groups. Data fail to support previous suggestions that giant cell arteritis or polymyalgia rheumatica patients may be an increased risk for hypothyroidism or hyperthyroidism. They lend no indirect support to the hypothesis that giant cell arteritis and polymyalgia rheumatica may be autoimmune disorders.

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