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Biomedical subjects

P Alstrup

Publications and source records attributed to P Alstrup.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Vascular ring].

Explore the source record for details and available documents.

Aorta, Thoracic↗
PubMed1986

Survival in small cell lung carcinoma after surgery.

In a retrospective study of long term survival in patients with small cell carcinoma of the lung who had been treated purely by surgery, 1820 patients with lung cancer seen during the 15 years 1962-77 were reviewed and reclassified histologically and according to the TNM system. Of these patients, 924 had had resections and 284 exploratory thoracotomies. Cancer chemotherapy was not used in this period and radiotherapy was given only occasionally as palliative treatment. Seventy seven of the patients having pulmonary resections had small cell carcinoma (8.4%), and there were six survivors among the 71 with T1-2, N0-1, M0 tumours. The five and 10 year survival rates were both 12%. The histological specimens from these six patients with a small cell carcinoma who survived more than 10 years were re-evaluated and confirmed as small cell by an independent group of pathologists. It seems justified to conclude that a selected group of patients with small cell carcinoma should be treated by surgery alone without adjuvant chemotherapy, which might reduce the long term survival.

Carcinoma, Small Cell↗
PubMed1984

Diagnosis and repair of traumatic tracheal and tracheobronchial disruptions.

During the period from January 1968 to December 1982, 8 patients received emergency operations for traumatic tracheobronchial rupture in the Department of Thoracic Surgery, Odense University Hospital. Half of the lesions were the result of blunt trauma; the other half were penetrating injuries or iatrogenic lesions. All of them were treated within 24 hours by direct suture of the lesion. In our experience soft, rapidly absorbable sutures should be used in the cartilaginous and membraneous parts of the larynx and trachea, and tracheotomy should be avoided where at all possible. Using these principles we have been able to avoid completely any cases of re-stenosis with its attendant complications. After operation , most patients could respire normally, and they recovered well after a few hours or days of using an uncuffed nasotracheal tube.

Adult↗
PubMed1984

Resection of acquired tracheal stenosis in childhood.

In a series of 74 tracheal resections, six were performed in boys aged 2 to 13 years. One patient was intubated shortly after operation because of bulbar paralysis with swallowing difficulties. He died 5 months later of traumatic hydrocephalus. Another patient was reintubated because of an accompanying nondiagnosed glottis stenosis which later was treated successfully. Four patients have been followed up from 4 to 10 years. In these patients tracheoscopy and x-ray examination have shown that the anastomosis has grown at the same rate as the rest of the trachea. It is concluded that operation can be performed in children at any age provided that swallowing is normal and accompanying laryngeal stenosis is excluded.

Adolescent↗
PubMed1983

The effect of coronary artery bypass surgery on ventricular arrhythmias.

The effect of coronary artery bypass surgery (CAB) on ventricular arrhythmias (VA) was studied in a prospective investigation involving 32 patients (mean age 54 years) who underwent CAB because of severe stable angina pectoris. Prior to CAB as well as 12 months later each patient was subjected to the following investigational programme: resting ECG, exercise ECG, 24-h ECG, selective coronary arteriography, ventriculography and cardiac catheterization. Exercise ECG showed VA in only three patients. The prevalence of VA during 24-h ECG was 56 and 66% on the two occasions (NS), while complicated VA (multiform, repetitive, R on T) was seen in 18 and 28%, respectively (NS). The persistence (number of 6-h periods showing VA) was 33 and 47% with regard to any VA (P less than 0.05), while complicated VA occurred in 13 and 15% of the 6-h periods (NS). Except for an increase in dp/dtmax/P at the postoperative measurement (P less than 0.05), no significant change in the performance of the left ventricle was seen after CAB though the graft patency was 77%. It is concluded that in patients with 'medically intractable' stable angina pectoris, CAB does not effect the occurrence of VA to any great extent--probably because left ventricular function is unchanged one year after as compared with that prior to CAB.

Adult↗
PubMed1983

Regression of infundibular hypertrophy after pulmonary valvulotomy without myocardial resection.

In the period 1965-1979, 26 patients underwent valvulotomy for congenital pulmonary valve stenosis without ventricular septal defect. Infundibular stenosis was additionally present in 14 of the patients, 12 children and 2 adults, but myocardial resection in the infundibular area was not performed. During the first postoperative year the right ventricular outflow tract underwent normalization in the 12 children and the right ventricular systolic pressure normalized in all 14 patients. No relationship could be demonstrated between the R wave in the precordial lead V1 and the systolic pressure in the right ventricle, the gradient to the pulmonary artery or the extent of subvalvular hypertrophy.

Adult↗