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Biomedical subjects

P Aiginger

Publications and source records attributed to P Aiginger.

53 records · Page 3Linked to original sources
PubMed1979

[Serum fucosyltransferase activity in malignant diseases].

Serum Fucosyltransferase activities were measured in 41 controls and in 55 patients with neoplastic diseases. Incorporation of 14C-fucose into the endogenous acceptor of serum and after addition of desialofetuin as exogenous acceptor, was determined. About 83% of patients suffering from various malignant diseases showed pathological fucosyltransferase activities. In all patients with testicular tumours and no detectable metastases after surgery, normal enzyme levels were obtained. After successful chemotherapy, fucosyltransferase activities returned to normal.

Female↗
PubMed1979

[Anemia in patients with malignant testicular tumors].

Changes in erythropoiesis were studied in 94 patients with testicular germ cell tumours (24 seminoma, 70 nonseminomatous tumours). Additionally ferrokinetic studies with 59Fe were performed in 29 patients with proven metastases. Only 2 of 37 tumour-free patients sustained moderate anemia after recess of primary therapy (2 seminoma, after X-ray-irradiation). In patients with disseminated tumour disease the anemia and the reduction of 59Fe-utilisation correlated positively with the elevation of serum estradiol concentrations, whereas no correlation could be established with testosterone serum levels.

Anemia, Hypochromic↗
PubMed1979

[Ixoten therapy in malignant lymphomas].

Clinical experience with Ixoten (trofosfamide), a derivative of cyclophosphamide, is reported in 29 patients with malignant lymphomas. Daily doses of 150-300 mg p.o. and 6.000-200.000 mg total dose respectively, resulted in an 80% complete or partial remission. In addition to a dose dependent haematotoxicity, other side effects (gastrointestinal and/or hair loss) were almost negligible.

Adult↗
PubMed1979

[Hemolytic anemia in Hodgkin's disease].

In 12 of 128 patients with Hodgkin's disease (10%) haemolytic anaemia could be observed. In 3 of 12 patients an (auto-)immunological etiology of haemolysis was proven by the positive antiglobulin-test. In the rest of patients (9 of 12) the haemolytic syndrome could be explained by the concomitant enlargement of the spleen. In addition to high-dose prednisolone, splenectomy is the method of choice for the treatment of the haemolytic syndrome (4 of 6 patients). If adequate treatment of Hodgkin's disease is provided, the disease (2--37 months) will not be influenced by haemolytic anaemia.

Adolescent↗
PubMed1978

Copper in ankylosing spondylitis and rheumatoid arthritis.

To study the role of copper in inflammatory rheumatic diseases, serum copper, serum ceruloplasmin concentration, erythrocyte sedimentation rate, and radio-copper studies were performed in 11 male patients with ankylosing spondylitis, in 12 female patients with rheumatoid arthritis and in 7 normal male subjects. The occurrence of elevated serum copper and serum ceruloplasmin levels can be confirmed in our study for patients with ankylosing spondylitis and rheumatoid arthritis when compared with normal controls. A significant correlation was found for these parameters and the inflammatory activity, characterized by the erythrocyte sedimentation rate. If groups with similar inflammatory activity are compared, higher ceruloplasmin concentrations are found in ankylosing spondylitis than in rheumatoid arthritis, the plasma incorporation of radiocopper also being higher in ankylosing spondylitis patients. Therefore, and because of comparable total serum copper concentrations, the non-ceruloplasmin bound copper level is found to be significantly higher in rheumatoid arthritis patients than in the group of ankylosing spondylitis patients. The significant correlation between erythrocyte sedimentation rate and the cumulative 120-hour urine excretion of radiocopper is in good agreement with the chemical finding of an elevated urinary copper excretion found by others, supporting the concept that the elevation of serum and urine copper levels in inflammatory rheumatoid diseases can be considered as an acute phase response.

Adolescent↗
PubMed1978

[Pathogenesis of hyperthyroidism].

The present concept for the etiology of thyroid disease permits the definition of three separate entities occuring with hyperthyroidism: Graves' Disease, Toxic Nodular Goitre, Autonomous Adenoma. Physiopathological properties of these entities lead to a rational therapeutic strategy for each one of them.

Adenoma↗
PubMed1978

[Steroid receptors--their meaning in the treatment of breast neoplasms].

Quantitation of estrogen and progesterone receptors in breast cancer has contributed to a better understanding of the prognosis of hormone treatment. In case of lymph node involvement adjuvant chemotherapy is indicated in estrogen receptor negative tumours. In patients with positive estrogen receptor pattern, hormone treatment eventually combined with chemotherapy is recommended. Comparable results are found after treatment with antiestrogens, side-effects, however, are found less frequently.

Breast Neoplasms↗
PubMed1978

[Therapeutic progress in malignant testicular neoplasms].

Besides the progress of surgical and radiological regimens it is a new approach in cytostatic chemotherapy which has improved the prognosis of testicular tumours. Combination chemotherapy results in a 70 to 100% remission rate and a prolonged duration of survival.

Antineoplastic Agents↗
PubMed1978

[Diagnostic progress in testicular carcinoma].

The diagnostic value of the serum tumour markers, beta-HCG and AFP, is investigated in 71 patients with malignant testicular tumours. Regular screening with beta-HCG and AFP, has improved the early diagnosis of recurrences and metastases in nonseminomatous testicular tumours.

Choriocarcinoma↗
PubMed1977

[Behaviour of erythrocytes in patients with aortic of mitral stenosis (author's transl)].

The behaviour of red blood cells was studied in 17 patients with aortic stenosis and 14 patients with mitral stenosis. Anemia was present only in 1 out of 17 patients with highgraded aortic stenosis. 8 of the 17 patients showed a reduced survival time of the red blood cells indicating hemolysis in a compensated stage. 14 cases of mitral stenosis showed no evidence of hemolysis. There was a significant inverse relationship (r = --0,85) between the valve gradient and the survival time of the erythrocytes in patients with aortic stenosis; valve area and survival time were directly related (r = 0,75). In mitral stenosis, there was no significant correlation between gradient or valve area and survival time. This suggests that the gradient through the valve rather than the reduced valve area is responsible for the damage of the erythrocytes; in addition, hemolysis appears to be dependent on pressure gradient rather than on valve pathology or reduction of valve area per se.

Anemia↗
PubMed1975

On the existence of intrahepatic bile duct shunts.

A combined scintigraphic-radiological method has been used to study the existence of intrahepatic shunts between the bile ducts of the right and left duct systems. With this method no shunts were found between the left and the right system. The results are compared with the findings reported in the literature.

Bile Ducts, Intrahepatic↗
PubMed1975

[Liver scanning in diffuse liver disease (author's transl)].

The results of liver scans performed with 99mTc-sulphur colloid in 169 patients suffering from diffuse liver diseases and in 48 normal controls were evaluated. The patients with reactive hepatitis, acute hepatitis, chronic persistent hepatitis, fatty liver and fibrosis of the liver show only minimal deviations from the scintigraphic pattern. On the contrary, highly increased colloid uptake in the spleen is found in cases of chronic aggressive hepatitis, whilst the intrahepatic distribution of the colloid is approximately normal. In cases of liver cirrhosis, increased colloid uptake is found in the left lobe of the liver as well as in the spleen and in the bone marrow. Either normal findings or cirrhosis-like changes of the colloid distribution are observed in patients with alcoholic hepatitis.

Bone Marrow↗
PubMed1975

[Serum concentration of triiodothyronine in autonomous thyroid gland adenoma].

Serum Concentration of T3 was measured in 14 patients with autonomous thyroid adenoma using a chromatographic method. 9 patients had increased levels of T4, 5 were normal. In both groups serum-T3-concentration was significantly elevated. In patients with normal T4-values hypertriijodothyroninemia seems to be the biochemical base for clinical signs of hyperthyroidism. The pathogenetical importance of elevated T3-levels is discussed for T3-secretion and T4/T3 conversion.

Adenoma↗