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Biomedical subjects

P Aiginger

Publications and source records attributed to P Aiginger.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Treatment of breast cancer at the 1st Gynecology Clinic at the University of Vienna].

Since 1979 diagnosis, operative therapy and postoperative treatment and follow-up is performed at the Ist University-Clinic of Obstetrics and Gynecology in Vienna. This management brought a close cooperation with radiologists and other oncotherapists. A standard operation method, in our case a modified radical mastectomy with a complete dissection of the axilla after radioisotope marking of the axillary lymph nodes enables us to perform a randomised prospective study of adjuvant therapy. Though the observation time is relatively short, first results show, that metastases or local recurrences were observed only in the non-treated control group. That leads in our opinion to the cautious conclusion, that any form of adjuvant therapy is of therapeutic value. Which form of adjuvant therapy should be qualified best cannot be decided yet because of the too short follow-up period.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

[Importance of the intracellular detection of alpha-fetoprotein and beta-human chorionic gonadotropin in a testicular tumor using immunoperoxidase].

30 patients with testicular cancer (20 seminoma, 10 non-seminomatous tumours) were investigated with respect to the determination of alpha-fetoprotein and beta-human chorionic gonadotropin in formalin-fixed slices by means of the indirect immunoperoxidase technique. The immunohistochemical method detected HCG-producing cells in 8 seminoma, whereas routine histology revealed syncytiotrophoblastic giant cells in 4 cases only. The immunohistochemical results and the serum AFT, and/or HCG values obtained by radioimmunoassay corresponded well in all patients with non-seminomatous tumours. Direct evidence of HCG production in the primary tumour can be important in therapeutic decisions, especially in patients with seminoma. The direct proof of AFP in the primary tumour might answer in the future the question of the incidence and the prognostic impact of yolk sac tumour parts in malignant teratomas.

Chorionic Gonadotropin↗
PubMed1984

Evaluation of serum fucosyltransferases in malignancy.

Incorporation of [14C]-fucose into the endogenous acceptor of serum and into the exogenous acceptors desialofetuin (alpha 2-fucosyltransferase) and desialodegalactofetuin (alpha 3-fucosyltransferase) was determined in controls and in patients with various malignant diseases. Seventy-five percent of untreated cancer patients showed increased incorporation rates into the endogenous acceptor of serum. Increased rates of alpha 2-fucosyltransferase activity were observed in 67% and of alpha 3-fucosyltransferase activity in 49% of patients respectively. After successful chemotherapy a fall of fucosyltransferase activities could be observed and in non-responding patients an increase of fucosyltransferase activities during and after therapy was found. Determination of fucosyltransferase activities might provide an additional biological marker in monitoring cancer patients.

Breast Neoplasms↗
PubMed1982

[Treatment of metastasizing breast cancer with aminoglutethimide].

Aminoglutethimide was applied for treatment of 10 patients (8 postmenopausal, 2 ovariectomized) with metastasizing breast cancer. The patients were extensively pretreated with cytostatic and hormonal measurements and already completely resistant to these therapies. Using aminoglutethimide (500-1000 mg daily) plus additional substitution with 20-40 mg hydrocortisone one complete and three partial remissions could be achieved. Stabilization was observed in 3 cases. The duration of remission varied between 4-8 months in 3 cases and lasted one month in a further patient.

Aged↗
PubMed1981

[Clinical and diagnostic value of computed tomography in retroperitoneal space-occupying extrarenal and extrapancreatic lesions (author's transl)].

In order to determine the diagnostic accuracy and clinical value of CT in the detection of retroperitoneal tumours and tumour-like conditions an evaluation was conducted of 397 CT examinations in 287 patients. Staging, monitoring of therapy and detection of relapse of the disease are the main indications for CT examination. CT should be used in the first place in the course of diagnostic staging procedures of patients with malignant tumours and tumour recurrence. This is justified by an overall diagnostic accuracy of 90% and the ability of CT to show up the exact localization and extent of tumours and the different patterns of lymph node involvement.

Adolescent↗
PubMed1981

[Value of beta-HCG blood levels in patients with malignant tumors of the testis].

In 24 of 43 patients (56%) with malignant germ cell tumors of the testis, the serum was positive for HCG prior to ablation of the testis. We give a detailed account of the course of HCG levels in the serum of 7 patients with seminoma of the testis. Positive serum-HCG-findings 8 to 10 days after semi-castration and prior to retroperitoneal lymphadenectomy indicate tumor metastases. In two thirds of our patients, we observed a correlation between regression of metastases under chemotherapy and the pattern of serum-HCG-levels.

Adult↗
PubMed1981

The endocrinology of testicular germinal cell tumors.

Oestradiol (Oe2), testosterone (T), lutenizing hormone (LH), follicle stimulating hormone (FSH), beta-human chorionic gonadotrophin (beta-hCG) and alpha-1 foetoprotein (AFP) were measured in blood samples taken from 63 patients with testicular tumours. In patients without tumour recurrence (n=31) AFP, Oe2 and T were within the normal range, beta-hCG was negative, LH levels were marginally elevated and FSH concentrations were significantly elevated. In patients with tumor recurrence (n=32) Oe2 was significantly elevated, whereas the T levels varied considerably and were therefore statistically not different from the patients without tumour recurrence. The beta-hCG positive subgroup of the recurrence group, however, demonstrated significantly elevated T levels. T levels were highest in patients with 51 to 500 U beta-hCG/1. On hand T was normal or even low normal in beta-hCG negative -AFP positive patients. In all subgroups decreasing FSH levels and decreasing LH responses to LRH were among the earliest signs of tumour recurrence. The observations suggest that moderate hCG levels are able to stimulate testicular T production, whereas high levels no longer increase T serum concentrations. Increased conversion rates form steroid precursors to oestradiol seem to be a feature of beta-hCG positive as well as beta-hCG negative testicular tumours.

Choriocarcinoma↗
PubMed1981

[Proteinase inhibitors and fibrinogen split products in patients with malignant diseases (author's transl)].

Fibrinogen degradation products could be detected frequently in patients with metastasized tumour disease. Plasminogen, antithrombin III and fibrinogen were not found to be elevated. The proteinase inhibitors alpha 2-macroglobulin, alpha 1-antitrypsin and C1-esterase inactivator were measured before and after chemotherapy. alpha 1-antitrypsin and C1-esterase inactivator were elevated in patients with pulmonary and/or retroperitoneal metastases. Regardless of the stage of the tumour disease serum level of alpha 1-antitrypsin and C1-esterase inactivator in increased under cytotoxic chemotherapy.

Antifibrinolytic Agents↗
PubMed1979

[The biological classifications of malignant thyroid tumours (author's transl)].

Carcinomas of the thyroid gland display large pathological and clinical variation. Favourable prognostic factors accompary well-differentiated tumours, whereas poorly differentiated or anaplastic carcinomas tend to invade early and are usually rapidly fatal. Experience has demonstrated the difference in rate of growth, subsequent recurrence and late spread even in identically well-differentiated thyroid carcinomas. Biological difference must be the underlying reason for the clinical difference in behaviour of histologically similar cancers. This report demonstrates the correlation between in vivo radioactive iodine uptake, tumour staging and recurrence-free interval in 30 thyroid carcinomas. The uptake by well-differentiated carcinomas staged T2N0M0 is significantly higher than that by tumours staged T3N1M0, whereas the latter show a higher uptake than those tumours staged T3N1M0. A high tumour uptake rate is correlated with long recurrence-free interval (up to 24 months) within all groups of staging and vice versa.

Humans↗
PubMed1979

[Circulating immune complexes in patients with malignant diseases].

Circulating immune complexes were determined by a solid phase C1q assay in patients with divers malignancies. In Hodgkin's disease (n = 20), immune complexes were detected only in two patients during chemotherapy. Both patients succumbed shortly thereafter. In patients with testicular malignancies (n = 18), immune complexes were detected especially in patients without evidence of metastatic disease. Sequential investigations did not reveal prognostic insights. Summing up these data and the data obtained in additional patients with malignancies, it is interesting to note, that patients with carcinomas have a significant higher incidence of circulating immune complexes with malignancies of the lymphatic system. Our data, however, do not exclude presence of other than C1q binding immune complexes.

Hodgkin Disease↗
PubMed1979

[Diagnosis and therapy of hepatocellular cancer].

A patient with hepatocellular carcinoma of the right liver lobe is presented by case report. Although a right side hemihepatectomy was performed, a recidive was detected 3 months later. Since then he received adriamycin-therapy and 14 months after operation, he is almost completely free of pain. Diagnosis, and surgical as well as internal therapy, are presented.

Carcinoma, Hepatocellular↗
PubMed1979

[Oral 5-fluorouracil therapy in liver metastasis].

The therapeutic results of 5-FU given by oral application (15 mg/kg body weight x 10 days) in 11 patients with hepatic metastases (after colorectal and mammary carcinoma) are reported: objective response in 2 patients and subjective improvement in 4 patients contrasts to 3 patients without response and 2 patients with indefinite response to adjuvant chemotherapy. However, a long lasting complete remission in a female patient with important metastatic hepatic involvement following breast cancer must be emphasized.

Administration, Oral↗