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Biomedical subjects

O Yoshida

Publications and source records attributed to O Yoshida.

At least 631 records · Page 35Linked to original sources
PubMed1983

[The effect of prostaglandin F2 alpha on the gastrointestinal movement after urological surgery].

To facilitate postoperative flatus, Prostaglandin F2 alpha (PGF2 alpha) was given intravenously to 23 patients who underwent urological operations. The patients were 14 males and 6 females aged from 20 to 77 years old. Patients with hypertension or cardiovascular disease were not included. Twelve operations were performed under general anesthesia, and 8 under epidural anesthesia. Thirteen operations were performed for the upper urinary tract or adrenal gland, and 5 were for the lower urinary tract. In 2 cases, the peritoneal cavity was opened and operations were performed on the intestines. PGF2 alpha 2000 micrograms was added to the postoperative drip infusion and administered in 2 to 3 hours. Until the first flatus was recognized, PGF2 alpha was given once a day in the same manner. Twenty-six patients, 10 of whom were given either vagostigmine or pantothen postoperatively, served as the control group. PGF2 alpha accelerated the postoperative flatus by 8.7 hours (mean) compared with the control group, but it was not significant. The onset of flatus was significantly promoted under epidural anesthesia. Gastrointestinal movement tended to be facilitated in the PGF2 alpha group after lower urinary tract surgery and in the patients over 50 years old. Three patients complained of severe abdominal pain as a side effect; and, injection of PGF2 alpha was stopped. In 7 patients, mild stomachache , vascular pain, nausea, vomiting or elevation of blood pressure were observed.

Adult↗
PubMed1983

A colony-stimulating-factor-producing cell line derived from mouse bone marrow cells transfected with adenovirus DNA.

A unique fibroblastoid cell line, BMA1, has been established from bone marrow cells of a DDY mouse transfected with adenovirus 5 DNA. BMA1 cells expressed adenoviral early antigens and BMA1-conditioned medium contained mouse granulocyte/macrophage colony-stimulating factor(s). The DNA transfection technique may be useful in establishing cell lines from bone marrow and analyzing the regulation of hemopoiesis.

Adenoviridae↗
PubMed1983

Suppression of granulocyte-macrophage colony formation in vitro by conditioned medium derived from human bladder cancer cells.

Media conditioned with 8 cell lines were assayed for stimulating and inhibiting activities on granulocyte-macrophage colony formation from bone marrow cells in soft agar (CFUc). Conditioned media from 3 human bladder cancer cell lines (EJ, T24 and KK47) and a rat bladder cancer cell line (BC50-TC) showed marked inhibition of mouse CFUc. Conditioned medium from normal human bladder cells showed a weak colony-stimulating activity, and only a slight inhibition when added to CFUc culture. Conditioned media from mouse or rat fibroblast cell lines (BLP and 3Y1) showed no colony-inhibiting activity, and the conditioned media from human lymphoblastoid cell line (Raji) and human epithelia-like cell line from amniotic membrane (FL) showed moderate inhibitory activity. No colony-stimulating activity was detected in any of the cell lines tested. EJ-conditioned medium inhibited human CFUc, but not erythroid progenitors. Colony-inhibiting activity in EJ-conditioned medium appears not to be prostaglandins; it needs more than 3 hr to inhibit CFUc, is stable at 56 degrees for 30 min but not at 75 degrees for 20 min, and is susceptible to proteolytic enzymes.

Animals↗
PubMed1983

[Clinical studies on the prognosis of 150 cases of acute renal failure].

A survey has been made of 150 cases of acute renal failure (A.R.F.) seen between 1962 and 1981. The overall mortality was 43.3%. The patients ranged from 7 to 75 years old. The mean age of all the patients was 47.2 years old. The mean age of the patients seen between 1970 and 1981 was 58.1 years old, 20 years older than those seen between 1962 and 1969. Despite increasing expertise in management of the complications of surgical, medical, and obstetric disorders, and considerable technical advances in dialysis, there was no decrease in mortality over the 20-year period of survey. Many factors have been identified as having an adverse influence on prognosis, such as age of patient, surgical origin, and complications. Mortality rate was high in the patients over 71 years old, postsurgical group (55.6%), and hepatorenal syndrome group (92.3%). Five major complications had an adverse influence: septicemia (57.1%), respiratory infection (61.1%), cardiovascular disorder (46.3%), hemorrhage (59.6%), unconsciousness (62.2%), and hepatic dysfunction (56.8%). Between 1970 and 1981 the mortality in the patients dialyzed up to 3 times was 81.3%, compared with 26.5% in those dialyzed from 4 to 19 times (p less than 0.01). In the former group severity of the underlying disorder had an adverse influence on prognosis. Although the A.R.F. may be controlled in the earlier stages of illness, many of these patients die of overwhelming infection or other complications.

Acute Kidney Injury↗
PubMed1983

[A case of ovarian dermoid cyst with bladder perforation].

A 60-year-old female presented with the main complaints of hematuria, pain upon urination, and pollakiuria. Simple abdominal X-rays revealed a dumb bell-shaped calculus shadow, and a calculus was detected in the right posterior wall by cystoscopy. At surgery, a left ovarian dermoid cyst accompanied by a calculus that was adhesive and perforating in the right posterior wall of bladder was detected. Twenty-eight cases of ovarian dermoid cyst with bladder perforation including this case are reported.

Calcinosis↗
PubMed1983

[Regional renogram and functional imaging with I-123-orthoiodohippurate in obstructive nephropathy].

Renal scintigraphy and regional renography using I-123- orthoiodohippurate were performed in 26 cases of obstructive nephropathy. After 1 mCi of I-123- orthoiodohippurate was given intravenously, serial renal scintigrams were obtained for 25 minutes and regional renogram curves were derived from the whole kidney, the cortical and pelvic areas. At the same time, renal functional images with Tmax as the peak arrival time were processed. Tmax in normal cases ranged from 2 to 3 minutes in the cortex and from 4 to 5 minutes in the pelvis, while there was some delay in Tmax in the obstructive nephropathy. In the case of acute ureteral obstruction by stones, most of the regional renograms in the cortex and pelvis improved soon after the removal of the obstruction. On the contrary, in the case of chronic obstructive nephropathy obstructive patterns on renogram curves was usually observed postoperatively. However, in some cases, functional images in cortical and/or pelvic areas showed marked recovery before improvement of findings on renograms or IVP. I-123- orthoiodohippurate renoscintigraphy is a useful adjunct for assessing pre- and post-operative renal function in obstructive nephropathy. Particularly, the analysis of regional renogram curves enables early prediction of postoperative recovery, and the functional image enables early detection of the functional recovery of the hydronephrotic kidney.

Adolescent↗
PubMed1983

[Familial vesicoureteral reflux].

Primary vesicoureteral reflux was seen in 2 siblings in a family of 5 (1 daughter and 2 sons). Voiding cystogram of elder sister, who complained of fever and backache, showed bilateral reflux at the age of 6. Left reflux disappeared soon but right reflux persisted. Right antireflux operation was performed at the age of 9, but right renal function deteriorated gradually. Right nephrectomy was done at the age of 12 because of persistent pyuria and renal stones. The second case was her younger brother who was sent to us because of proteinuria and hypertension. Excretory urogram showed left small kidney and voiding cystogram showed bilateral reflux with moderately dilated ureter and calyceal blunting. Urinalysis revealed normal findings except for proteinuria and he had no urological symptoms. Renal angiogram and renal vein renin study were unremarkable, so bilateral antireflux operation was done. Findings of urinalysis of his parents and younger brother were normal and cystogram of his brother was normal.

Adolescent↗
PubMed1983

Parathyroid cysts with primary hyperparathyroidism: report of a case.

Cysts of the parathyroid glands are uncommon, and, moreover functioning parathyroid cysts that cause primary hyperparathyroidism are rare. Herein is reported a 53-year-old female with primary hyperparathyroidism accompanied by 2 parathyroid cysts, in one of which adenoma was noticed. Forty-two cases of parathyroid cysts were found in the Japanese literature. Twelve of them were in the hyperparathyroid state, but infarction of the adenoma lead to cystic degeneration in most of such cases and so the cyst wall were lined with adenoma cells. In only 2 cases including our case were the cyst walls lined with cuboid cells and the adenoma evident in the wall. The pathogenesis of our case seems to be a common embryonic defect or dilatation of vestigial remnants rather than a degenerative change of the adenoma.

Cysts↗
PubMed1983

Cataracts in rats given a bladder carcinogen, N-butyl-N-(4-hydroxybutyl)-nitrosamine.

Cataracts were incidentally found at week 30 in six out of 65 female Wistar rats given a urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in a 0.05% solution in drinking water for 8 weeks and then treated with mitomycin C, a retinoid or a combination of both. No cataracts were found in 12 control rats given no carcinogen. Although the difference in the incidence was not significant statistically, the present finding suggests the possibility that administration of BBN induces or facilitates the development of cataracts.

Animals↗
PubMed1983

[A review of the cases of testicular tumors reported in the Annual of Pathological Autopsy Cases in Japan].

A review was made on 1,437 cases of testicular malignancies reported in the Annual of the Pathological Autopsy Cases in Japan between 1967 and 1976. They were 417 cases of germinal testicular cancer and 1,027 cases of secondary tumors, the ratio between the two being 1:2.46. The primary disease of 966 cases of secondary tumors was known: It was leukemia in 541 cases (56%), cancer in 188 cases (19.4%) and lymphosarcoma in 184 cases (19.0%), in decreasing order of frequency. The histological classification of the 410 germinal cell carcinoma given clear description was type I, II, III, IV and V according to Dixon and Moore's classification in 34.4%, 38.5%, 3.7%, 10.2% and 13.2%, respectively. There were 369 cases consisting of only one histological type, which was seminoma, embryonal carcinoma, teratoma, teratocarcinoma and choriocarcinoma in 38.2%, 39.0%, 3.8% 10.0% and 9.0% of these cases, respectively. The pattern of metastasis was analyzed for these 369 cases. There was no significant difference in the pattern of lymph node metastasis between the 5 groups, but there was a slight difference between seminoma and embryonal carcinoma. There was a significant difference in the pattern of distant metastasis between the 5 groups and between choriocarcinoma and seminoma, choriocarcinoma and embryonal carcinoma, and, choriocarcinoma and teratocarcinoma. It is questionable whether the findings at autopsy directly relate to prognosis, but considering from the pattern of metastasis at autopsy, the adult germinal cell testicular tumors can be divided into the three groups: seminoma, choriocarcinoma and embryonal carcinoma + teratocarcinoma + teratoma.

Adolescent↗