Biomedical subjects
Publications and source records attributed to O Teodosiu.
A number of 92 viral agents could be isolated from 1,000 nasopharyngeal secretion samples collected from apparently healthy schoolchildren aged 7-14 years. The following viruses were identified, in decreasing order of frequency: 42 influenza A/USSR 90/77 (H1N1), 20 adeno-, 20 parainfluenza, 8 Coxsackie B1 and 2 herpes virus strains.
Attempts performed with 39 samples of nasopharyngeal secretion resulted in the isolation of 21 (54%) hemagglutinating viral agents in chorioallantoic membrane (CAM) fragments, while a single strain (2.5%) was isolated in the embryonated egg. The time interval required for virus isolation in CAM fragments ranged from 4 to 20-24 days and was longer then 10 days in the embryonated egg. Maintenance of CAM fragments in roller tubes leads to a more abundant virus multiplication and, implicitly, to a reduction of the time interval necessary for virus isolation.
Virus isolation attempts were made with 500 nasopharyngeal secretion samples from apparently healthy schoolchildren aged 7-14 years, vaccinated by nasal route with an inactivated influenza vaccine and with 500 samples from unvaccinated schoolchildren of the same age. The number of virus isolates obtained was much smaller in the former than in the latter group (13 as against 50 virus isolates). The role of influenza vaccination in the protection of schoolchildren against respiratory tract infections is discussed.
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Studies conducted for over 20 years allowed the authors to accumulate a rich experience in the production and administration of an inactivated influenza vaccine applicable by nasal and oral route, prepared in the "Stefan S. Nicolau" Institute of Virology. Applied as a monovalent in a single dose of 1000 IU, the vaccine induced seroconversion of 70% of the vaccines and ensured a 2--4-fold decrease in influenza morbidity. Owing to these qualities the vaccine represents one of the most advantageous preparations used in influenza prophylaxis.
The thymus polypeptide extract TP1 administered to X-rayed animals shows a protecting effect on the level of serum anti-influenza antibodies in the rats inoculated with A2 influenza vaccine and reduces the haemagglutinating titres in the mice inoculated with the A PR8 influenza virus.
The virological study of some influenza outbreaks recorded in Romania in the period Jnauary--March 1975 resulted in the isolation of 29 influenza A2 virus strains antigenically close to the strains A2/Port Chalmers 1/73 and A2/England 42/72. The non-homogeneous antigenic structure of the isolates suggests the possible formation of natural hybrids.