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Biomedical subjects

O Takamiya

Publications and source records attributed to O Takamiya.

At least 55 records · Page 3Linked to original sources
PubMed1989

Ultrasonographic measurement of the fetal transverse cerebellum in utero.

Ultrasonographic examinations, done to measure the fetal transverse cerebellar diameter (FCD), were performed in 116 women with regular menstrual cycles, at 17-40 weeks of gestation. FCD correlated well with gestational age (r = 0.96, p less than 0.001). The 95% confidence interval of the linear regression was also given. FCD may be a more useful indicator of the accurate gestational age in case of dolichocephaly or brachycephaly, and facilitate antenatal detection of congenital disorders.

Cerebellar Diseases↗
PubMed1989

Antenatal measurement of scapula length using ultrasound.

In 76 fetuses from 14 weeks of gestation through to term, measurements of the scapula were made using ultrasound. Statistical analysis of the results revealed a highly significant correlation between scapula measurements and gestational age, biparietal diameter, fetal femur length and fetal abdominal circumference (r = 0.93, 0.91, 0.95, and 0.91, respectively). In particular, values related to length of the scapula were highly correlated with femur length. These findings show that this measurement is useful as an adjunct to assessing development as well as growth of the femur and dating parameters of the fetus in utero.

Embryonic and Fetal Development↗
PubMed1989

Ultrasonic evaluation of liver development in the fetus in utero.

A total of 573 measurements of the human fetal liver size were made from 18 to 41 weeks gestation. The right hepatic lobe increased linearly throughout gestation, whereas the left lobe increased linearly until approximately 32 weeks gestation, after which a slight slowing was observed. There was a significant correlation between both hepatic lobe sizes and gestational age (r = 0.94, r = 0.88; p less than 0.01, p less than 0.001).

Embryonic and Fetal Development↗
PubMed1989

Doppler color flow mapping of an invasive mole.

We report here Doppler color flow mapping carried out before and after chemotherapy for an invasive mole. This mapping revealed an abnormal color blood flow within the echo-free space in the uterine myometrium, and pulsed Doppler ultrasound showed a prominent arteriovenous shunt flow. Similar features were obtained by pelvic angiography (PAG). After 4 courses of chemotherapy, the area of abnormal colored flow was reduced and findings on the PAG were supportive. The patient is being closely followed, using Doppler color flow mapping.

Adult↗
PubMed1989

Ultrasonographic identification and measurement of the normal ovary in postmenopausal Japanese women.

Real-time ultrasonic scanning examinations were performed on 31 postmenopausal Japanese women with no evidence of pathology. Both ovaries were visualized in 25 patients. Only the left ovary was imaged in 5 and only the right one in 1 patient. Ovarian sectional area (OSA) was 1.45 +/- 0.61 cm2 in the left-sided ovary and 1.36 +/- 0.64 cm2 in the right-sided ovary, with no statistically significant difference. In all 56 ovaries, the OSA was 1.41 +/- 0.63 cm2. These normal values in postmenopausal women provide a useful indicator for detection of postmenopausal palpable ovary syndrome.

Aged↗
PubMed1989

Umbilical artery blood flow velocity waveforms and associations with fetal abnormality.

Blood flow velocity waveforms from the umbilical artery of 126 normal fetuses with no evident complications at 20-42 weeks of gestation and 15 fetuses with various abnormalities at 25-42 weeks were recorded using pulsed Doppler ultrasound. The resistance index (RI) was assessed on each blood flow velocity waveform. In 9 fetuses with a slight abnormality, the values of RI were within the mean +/- 2 SD of normal fetuses, and the outcome was good. In 3 of 6 fetuses with a serious abnormality, the values of the RI were high, and 2 of these fetuses died in utero within a few days after the recording. Another fetus with a high RI and 3 with a normal RI died neonatally. Therefore, Doppler ultrasound assessments of the umbilical artery blood flow velocity waveform in utero aid in predicting the outcome for fetuses with major abnormalities.

Blood Flow Velocity↗
PubMed1989

Transvaginal Doppler color flow mapping.

Transvaginal Doppler color flow mapping was performed on 8 Japanese women (normal, 1; menopause, 2; uterine myoma, 1; endometriosis, 2; pregnant, 2). In all 8, bilateral uterine arteries and branches could be clearly identified in shades of blue and/or red. The color flows were abundant in the pregnant women. Transvaginal Doppler color flow mapping is expected to be an important diagnostic tool for assessing uterine arterial blood flows in physiologic and pathologic conditions of the pelvis.

Endometriosis↗
PubMed1989

Fetal cardiac time intervals determined by Doppler echocardiography.

One-hundred and eleven Doppler echocardiographic examinations were performed on 88 normal fetuses, ranging from 16 to 41 weeks of gestation. Aortic and pulmonary maximal velocity (MV), acceleration time (AT), ejection time (ET), MV/AT (acceleration velocity: AV) and AT/ET ratio in systole were assessed on each blood flow velocity waveform. Aortic MV and pulmonary MV correlated well with gestational age, respectively. Good correlations between aortic AT, pulmonary AT and gestational age were evident. There were correlations between aortic AT/ET ratio, pulmonary AT/ET ratio and gestational age, respectively. However, there was no correlation between aortic AV, aortic ET, pulmonary AV, pulmonary ET and gestational age, respectively. These findings may relate to alterations in pulmonary and placental vascular resistance with advance in gestation.

Echocardiography, Doppler↗
PubMed1989

Ultrasonic evaluation of the normal uterus in the neonate.

Using real-time ultrasound, a study was undertaken to evaluate the morphology of normal uterus in the neonate delivered at term. The uterus was visualized in 41 (89.1%) of the 46 neonates. The cervical volume (CE-V) was 3.65 +/- 1.36 cm3, the corporeal volume (CO-V) 1.18 +/- 0.42 cm3, and the CE-V was significantly larger than the CO-V (p less than 0.001). The uterine volume (U-V) was 4.83 +/- 1.57 cm3, and U-V showed a good correlation with birth weight (r = 0.42, p less than 0.01). The endometrial echo was constantly depicted as a mixed echo of a highly echogenic line and/or a myometrial halo. These normal values and the morphology of the neonatal uterus provide useful information for distinguishing a possible pathologic pelvic mass and screening of congenital genital disorders.

Female↗
PubMed1989

Doppler ultrasound assessment of tumor vascularity in gynecologic disorders.

Real-time two-dimensional and pulsed-wave Doppler ultrasonic examinations were performed on 8 normal volunteers and 97 patients with various gynecologic disorders; the objective was to assess uterine and tumor vascularities. Each arterial blood flow velocity wave-form was classified into two types. The resistance indices of normal and abnormal flows were greater than .7 and less than .7, respectively. In normal volunteers, abnormal flows were nil. In 8 of 44 patients with benign tumors (18.2%), abnormal flows were evident and all proved to be cases of leiomyoma or adenomyosis. Doppler signals were not detected in 18 of 36 patients with cervical carcinoma (50%) and abnormal flows were noted in only 6 (16.7%). In all cases of endometrial carcinoma, ovarian carcinoma, and trophoblastic disease, typically abnormal flows were noted. Moreover, in most subjects a decrease in blood flows was observed after chemotherapy by anticancer drugs or irradiation. Therefore, Doppler ultrasound is a pertinent and noninvasive tool that can be used repeatedly for assessing the tumor vascularity in gynecologic disorders.

Adult↗
PubMed1989

Ultrasonographic evaluation of pelvic inflammatory disease.

The relative frequencies of various sonographic patterns and features of pelvic inflammatory disease (PID) were examined in retrospective analyses of sonograms in 36 proven cases. The original sonographic reports correctly predicted PID in 34/36 patients (sensitivity = 94.4%). Two cases were found to be tubo-ovarian abscess although at first they were reported to be ovarian neoplasia. The most frequent finding was dilatation of the fallopian tube (72.2%). String sign within the dilated tube that would reflect increased interface within the endosalpinx was found in 50.0%, fluid collection in the Douglas' pouch in 47.2%, which was confirmed by the culdocentesis and aspiration in 16 cases, and/or tumor formation at the adnexal region in 38.9%. These findings were characteristic but not specific in PID. Careful sonographic scrutinization should improve the diagnostic accuracy of PID in patients with low abdominal pain, high temperature and low back pain.

Female↗
PubMed1989

Fetal Doppler echocardiographic assessment of cardiac blood flow velocity in normal fetuses and in those with congenital heart disease.

Ninety fetal Doppler echocardiographic examinations were performed on 72 normal fetuses and 5 with congenital heart disease [2 pulmonary stenosis (PS), 1 pulmonary atresia (PA), 1 tetralogy of Fallot (TOF) and 1 endocardial cushion defect (ECD)] at 16 to 40 weeks of gestational age. The maximum transmitral (MVMax), transtricuspid (TVMax), transaortic (AVMax) and transpulmonary blood flow velocity waveforms (PVMax) were assessed. The detection rates for MVMax, TVMax, AVMax and PVMax in normal fetuses were 69.4%, 68.2%, 77.6% and 43.5%, respectively. MVMax, TVMax, AVMax and PVMax correlated well with gestational age, in the normal fetuses. However, there was no correlation between MVMax, TVMax, AVMax, PVMax and heart rate, in the normal fetuses, respectively. The TVMax/MVMax ratio was one and over in 53 of 55 normal fetuses (96.4%), and the PVMax/AVMax ratio was one and over in 11 of 25 normal fetuses (44%). In cases of PS, the TVMax was relatively low, but the PVMax was definitely high. The TVMax/MVMax ratios in cases of PS were 0.8 and 1.0, respectively. AVMax in a fetus with TOF was definitely low and markedly decreased in the case of ECD. Therefore, fetal Doppler echocardiography is a pertinent diagnostic tool which can be used to analyze cardiac hemodynamics in all fetuses, in utero.

Blood Flow Velocity↗
PubMed1988

Combined factor VII and protein C deficiency found in a patient with peripheral pulmonary artery stenosis accompanied by progressive pulmonary hypertension and hemoptysis.

A congenital deficiency of factor VII and protein C was found in a 21-year-old female suffering from recurrent and progressive attacks of dyspnea and hemoptysis over the last four years. She has been followed in our Department since the age of 17 under a diagnosis of peripheral pulmonary artery stenosis and pulmonary hypertension as confirmed by cardiac catheterization and angiography. Prolonged prothrombin time repeatedly examined during this time period prompted us to perform detailed coagulation studies. We found that factor VII and protein C were both half normal in activity as well as in antigen. Three other members of her immediate family were also found to be affected with this combined deficiency. Since the genes encoding factor VII and protein C are located in different chromosomes, the 13th and the second chromosomes, respectively, expression of the combined hereditary deficiency is a random and very rare association on the basis of frequencies of 1:50,000 for factor VII and 1:16,000 for protein C deficiencies.

Adult↗
PubMed1988

Factor VII activity and antigen in a patient with abnormal factor VII.

A patient with abnormal factor VII, which showed different activity when thromboplastin from different sources was used, is reported. The propositus, who was first seen at routine health examination 1 month after delivery, was a girl with no complaints of bleeding. The coagulation pattern was characterized by an abnormal clotting time using Normotest reagent which did not respond to the administration of vitamin K. Factor VII activity was decreased when measured using rabbit brain and lung thromboplastin, mildly decreased using human brain or human placenta thromboplastin and within the normal range using ox brain thromboplastin. The level of factor VII antigen was normal and revealed a normal mobility on immunoelectrophoresis. The molecular weight of this factor VII was not different from normal factor VII when analysed using autoradiography after sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). It seems probable that the propositus had an abnormality similar to the factor VII Padua 1 described previously.

Antigens↗
PubMed1988

Antenatal diagnosis of congenital heart disease and fetal arrhythmia by ultrasound: prospective study.

Fetal echocardiographic and Doppler ultrasonographic prospective studies were performed in utero on 299 babies delivered at Hirata Municipal Hospital, Shimane, Japan, from May 1984 to June 1986. Two or three ultrasonographic examinations were performed on each fetus from 20 weeks of gestation to term. Three congenital heart anomalies and 12 fetal arrhythmias were diagnosed antenatally, but 3 heart anomalies (2 small ventricular septal defects and 1 moderate pulmonary stenosis) were not detected in utero. Routine echocardiographic screening appears to be a useful diagnostic tool to detect congenital heart anomalies and fetal arrhythmia antenatally.

Arrhythmias, Cardiac↗
PubMed1988

Ultrasonographic evidence of ileus.

Twenty-seven patients with ileus were assessed using ultrasound and the related variables suggestive of ileus are presented. If special attention is directed to these variables when a patient complains of nausea, vomiting, colicky abdominal pain and so forth, this entity can be diagnosed early and accurately. Since the distended, air-filled loops of bowel are not so readily recognized, the combined use of X-ray and ultrasound will aid in a follow-up study during treatment as well as in the diagnosis.

Adult↗
PubMed1988

Succenturiate placenta diagnosed by ultrasound.

The succenturiate placenta is a morphological abnormality, the antenatal recognition of which is important as vessels connecting the main placenta with the succenturiate placenta may rupture during labor and fetal death may ensue. In addition, retention of the placental material may lead to postpartum hemorrhage. We treated 5 patients with a succenturiate placenta and the antenatal ultrasonograms and related discussions are presented herein.

Adult↗