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Biomedical subjects

O Schmucki

Publications and source records attributed to O Schmucki.

At least 19 recordsLinked to original sources
PubMed1986

Critical aspects of urine and stone analysis. Appearance of iatrogenic urinary calculi.

In 25% of the samples the often applied qualitative chemical analysis of urinary stones leads to entirely wrong results with severe therapeutic consequences. The appropriate techniques for stone analysis are infrared spectroscopy and X-ray powder diffraction. These techniques make also possible the identification of iatrogenic urinary calculi. Four types of such stones were detected here, caused by modern medication. N4-acetylsulfamethoxazole, N4-acetylsulfadiazine, mefenamic acid and silicon dioxide. It is only the correct preanalytical treatment of urine samples that prevents considerable impairment of analytical results. Without precautions especially, the oxalate concentration in urine may be doubled or tripled during one day of storage.

False Positive Reactions↗
PubMed1986

Clinical significance of stone analysis.

The bases of a real metaphylaxis in the renal stone diseases are the analysis of stones and the research of metabolism in blood plasma and urine. The greatest part of the stones analyzed may be classified in four groups: oxalate, phosphate, uric acid and cystine. The metaphylaxis by whewellite and weddellite is the same for both species but there is a distinction in growth and recurrence. In the phosphate stones, the section with the most different composition, a postoperative therapy is only possible with the distinction of 'acid' and 'alkaline' stones. The uric acid and cystine stones need a tight supervision and metaphylaxis for the whole life. On the basis of 15,000 analyses with X-ray diffraction the difference of the renal stones is discussed and the deducation for a genuine metaphylaxis is shown.

Adult↗
PubMed1982

Surgical resection of residual tumor after chemotherapy in non-seminomatous testicular cancer.

Fifteen patients with disseminated non-seminomatous testicular cancer, 13 of whom had advanced disease, underwent surgery for residual tumor after induction chemotherapy. Complete remissions were achieved in 7 of 9 patients with mediastinal or pulmonary metastases and in 2 of 6 patients with retroperitoneal metastases. Patients with alpha-fetoprotein (AFP) levels over 10(4) ng/ml at diagnosis and/or a positive AFP preoperatively failed to achieve complete remission. Complete remissions were obtained in all 8 patients who had resection of necrosis, mature teratoma, immature teratoma or mature teratoma with malignant foci, but in only 1 of 7 patients who had resection of embryonal carcinoma or yolk sac tumor with other components. Of 9 patients with complete remission, 8 have remained free of disease after a median follow-up time of 29 months (range 6-66 months) and one had a contralateral non-seminomatous testicular cancer removed after 60 months. In addition to being therapeutically successful, the combined use of chemotherapy followed by surgery for residual tumor may lead to a better understanding of the influence of chemotherapy on the biology of testicular carcinoma.

Adult↗
PubMed1979

[Medical support in surgery for pheochromocytoma].

The occurrence of hypertensive crises, arrhythmias and hypotensive crises during surgery for pheochromocytoma can be prevented both preoperatively and intraoperatively by adequate alpha-adrenergic blockade and volume replacement. Only in a few cases is additional beta-adrenergic blockade necessary. Preoperatively the author uses phenoxybenzamine (Dibenicyline) as alpha-blockade in a dose of 20-30 mg daily, and propanolol (Inderal) as beta-blockade in a dose of 4 X 20 mg daily, both given orally. Intraoperatively he gives preference to alpha-adrenergic receptor blockers with a short halflife, i.e. phentolamine (Regitin) and lidocaine or pranolol as the beta-adrenergic blocker.

Adrenal Gland Neoplasms↗
PubMed1979

[Experiences with instrumental methods for urinary calculi analysis].

To reduce the urinary calculi incidence by calculi formers, it is important to know the composition of these stones. Unfortunately the chemical analysis does not give very reliable results. Looking for a better method to analyse urinary calculi, three instrumental methods were tested: infared spectroscopy, thermal analysis and X-ray diffraction. The experimental results and economical considerations show that the X-ray diffraction analysis of urinary calculi would meet the goal of improved care of patients with stones.

Humans↗
PubMed1977

[Catheter embolization of a bleeding inoperable hypernephroma].

The indications for and technique of transcatheter renal embolization are demonstrated in the light of a case of inoperable hypernephroma. The embolization was performed with autologous muscle tissue and involved no serious complications. The efficiency of the technique is evidenced by the resultant reduction in hematuria. An interesting aspect is the possible formation of a tumor abscess one month after the embolization.

Adenocarcinoma↗
PubMed1976

[The treatment of prostatic adenoma].

Prostatic hyperplasia is a benign disease of elderly men. In 30-40% of the men the prostatic adenoma causes obstruction which requires operative treatment. 75% of these patients consult the general practitioner. Stage I is treated conservatively. Early surgery is indicated only in those undergoing surgery for hernia and in cases of intermittent obstruction. Operation is definitely indicated in stage II. Stage III should be treated initially with an indwelling catheter for 3-4 months. Treatment with lifelong indwelling catheter is rarely indicated today.

Androgens↗