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Biomedical subjects

O Sato

Publications and source records attributed to O Sato.

At least 253 records · Page 14Linked to original sources
PubMed1980

Syntheses of sulfur-containing nucleoside analogs.

Reaction of glycosyl isothiocyanates (1a,b,c) with diazo compounds or chloroethylamine gave glycosylamino-1,2,3-thiadiazoles and glycosylimidazolidine-2-thiones. Similar reaction of 1a,b with ethanolamine afforded N-glycosyl-N'-hydroxyethylthioureides, followed by treatment of thionyl chloride to give glycosyliminothiazolidines. N-Glycosyl-N'-amidionthiocarboxamides were treated with thionyl chloride to give glycosyl s-triazin S-oxides. N-Glycosyl-N'-(6-amino-1,3-dimethyl-2,4-dioxopyrimidin-5-yl)thioureides were oxidized with NBS into pyrimidotriazine glycosides.

Hexoses↗
PubMed1980

[Diagnosis of pituitary microadenoma by thin-section hypocycloidal tomography (author's transl)].

The authors stressed the reliability of lateral thin-section hypocycloidal tomography not only for the detection of pituitary microadenomas but also as an aid in surgical removal of them. Fourteen women with secondary amenorrhea were studied of which 13 cases showed high serum prolactin levels. Transsphenoidal surgery confirmed the presence of microadenomas less than 10 mm in all cases. The sellar volume measurement from plain radiographs of the skull was normal in all cases. The contour of the sella on plain lateral radiographs was abnormal in 4 cases (28.6%); double floor in 2 cases and localized ballooning in 2 cases. Hypocycloidal tomography was carried out at 2 mm intervals in both anteroposterior projection and lateral projection. Anteroposterior tomograms were abnormal in only 4 cases; each case with destruction of the sellar floor with small tumor shadow in the sphenoid sinus, central depression, lateral depression and sloping of the sellar floor. Lateral tomograms were, on the other hand, abnormal in all cases. Localized expansion with thinning in the anterior or anteroinferior portion of the sellar wall was found in 11 cases and the same finding in the inferior or inferoposterior portion of the sellar wall associated with thinning of the dorsum sellae was present in 3 cases. Lateral tomograms were considered more sensitive than anteroposterior tomograms from these results. We also studied the reliability of hypocycloidal tomography in the accurate localization of the tumor in comparing with the actual location of the tumor from the operative findings. In 12 cases the location of the tumor defined by hypocycloidal tomography was coincident with that by surgery. Moreover, when the sellar destruction was shown to be larger by hypocycloidal tomography, size of the tumor tended to be larger. These results suggested hypocycloidal tomography would be an accurate aid in surgical procedures.

Adenoma↗
PubMed1979

Non-communicating hydrocephalus caused by dural arteriovenous malformation.

The case of a female infant with a non-communicating hydrocephalus caused by an enormously dilated straight sinus and the dilated posterior one third of the sagittal sinus is presented. These sinuses drained a torcular dural arteriovenous malformation. Conray ventriculography revealed a complete obstruction of the junction of the aqueduct and fourth ventricle with cephaloventral displacement of the ventricular system by the dilated sinuses. Placement of a ventriculoperitoneal shunt was followed by artificial embolization, by selective catheterization, into the dural feeding arteries.

Arteries↗
PubMed1979

Facile syntheses of 1,2,4-triazole and s-triazine glycosides from glycosyl isothiocyanates.

Reaction of glycosyl isothiocyanates (la, b or c) with acyl or aroyl hydrazine gave the corresponding glycosyl thiosemicarbazides, and which were treated with Ac2O-H3PO4 to yield 1,2,4-triazole glycosides. Similar treatment of la, b or c with amidino compounds gave glycosylisothiobiurets, followed by N-bromosuccinimide (NBS) oxidation to give 1,2,4-triazole glycosides. Treatment of glycosylisothiobiurets with triethyl orthoformate gave the corresponding s-triazine glycosides.

Glycosides↗