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Biomedical subjects

O Munck

Publications and source records attributed to O Munck.

At least 109 records · Page 6Linked to original sources
PubMed1980

Background correction factors in renography with single probe detectors.

The background correction factor was determined with [131I]albumin, FA, in eighty-six patients with various nephro-urological diseases, with [131I]hippuran in eighty unilaterally nephrectomized patients (FH), and in twenty-five patients in whom the renogram showed background configuration, FH, B. FH was approximately the same on the left and the right side, the mean values being 1.39 and 1.35, respectively. FA showed a significant side difference, the mean values being 1.30 and 1.19 on the right side, respectively. FH, B was higher than FH, which shows that some uptake of hippuran can take place in apparently non functioning kidneys.

Background Radiation↗
PubMed1980

Renovascular hypertension treated by autotransplantation.

Renal autotransplantation was performed in 16 patients with severe renovascular hypertension. The hypertension was cured in 13 patients, 2 patients were improved and one patient had no benefit. The postoperative function and morphology of the transplanted kidneys remained unchanged. In our view, renal autotransplantation is a valuable method in the surgical treatment of renovascular hypertension.

Adult↗
PubMed1979

Mechanisms of edema formation in myxedema--increased protein extravasation and relatively slow lymphatic drainage.

We assessed extravascular accumulation of albumin and fluid in primary myxedema by measuring metabolic turnover and transcapillary escape of 131I-labeled human albumin in seven patients. In the hypothyroid state, we found a low plasma volume (P less than 0.05), a reduced rate of albumin synthesis and catabolism (P less than 0.01), an increased transcapillary escape rate of albumin (P less than 0.01), a remarkable increase in the extravascular mass of albumin (1500 micronmol; P less than 0.01) and a longer mean transit time through the extravascular spaces in primary myxedema than in other states of generalized edema (P less than 0.05). All variables returned to normal during l-thyroxine treatment. The extravascular accumulation of albumin, and presumably of all other plasma proteins, is important in the generalized edema typically found in myxedema. Inadequate lymphatic drainage may also explain the formation of exudates in the serous cavities that are well known in myxedema.

Adult↗
PubMed1979

The relationship between maximal oxygen uptake and glucose tolerance/insulin response ratio in normal young men.

Maximal oxygen uptake (VO2max.), glucose tolerance (K-value), and insulin response (IRI-area) were studied in seventeen young, non-obese, non-diabetic males. The ratio between K-value and IRI-area correlated significantly with VO2 max. (r = 0.70, p less than 0.01) also when differences in body fat mass were eliminated by partial correlation analysis (r = 0.56, p less than 0.05). Subjects with a high VO2 max. thus maintained a given glucose tolerance with a lower insulin response than did subjects in whom VO2 max. was low.

Adipose Tissue↗
PubMed1979

A follow-up study of hypertensive patients after operative treatment of unilateral renovascular or renal disease.

A study of 44 hypertensive patients with unilateral renovascular or renal parenchymal disease is presented. All patients underwent corrective surgery. Out of the 44 operated patients, five did not participate in the follow-up examination. The remaining 39 patients constitute the study population. The effects of surgery on the hypertensive state could be evaluated in 35 patients, whereas four died less than two months after the operation. Follow-up studies were carried out at 8-60 months after the operation. The average period of observation was 32 months; 24 patients were observed for more than two years. As a group, the patients had severe hypertension with extensive target organ damage and widespread atherosclerosis. A fairly rigorous selection process was applied, and an unsatisfactory response to medical management was considered a point of major importance. In the majority of cases, renovascular lesions were atherosclerotic, with only two cases of fibromuscular dysplasia. Unilateral nephrectomy was performed in 32 patients, whereas seven underwent reconstructive vascular surgery. Out of 35 patients, 22 (63%) were cured, 8 (23%) improved and 5 (14%) unaltered. A gratifying regression of hypertensive lesions in target organs was observed in patients who were cured or improved by surgery. The frequency and severity of postoperative complications were related to the presence of extrarenal vascular disease.

Adult↗
PubMed1979

Acute gastrointestinal bleeding detected with abdominal scintigraphy using technetium-99m-labeled albumin.

In 24 patients admitted with gastrointestinal bleeding 36 scintigraphic studies of the abdomen were performed after intravenous injection of technetium-99m-labeled albumin. In 12 patients bleeding from the esophagus, stomach, duodenum, biliary tract, or colon was visualized. In the other 12 patients, in whom the bleeding seemed to have subsided, the investigation showed no scintigraphic signs of hemorrhage. Scintigraphy was also negative in five controls who had no bleeding. The method is non-invasive and easy to perform. Our study suggests that it is reliable, but a controlled trial is necessary to evaluate the diagnostic value of the method.

Acute Disease↗
PubMed1978

[51Cr]EDTA plasma clearance and endogenous creatinine clearance in advanced renal insufficiency.

Comparison of [51Cr]EDTA plasma clearance corrected for extrarenal elimination with 24 h endogenous creatinine clearance in patients with advanced renal failure showed that the corrected [51Cr]EDTA clearance was lower than creatinine clearance, and thus might be a better approximation to the glomerular filtration rate in uraemic patients. The corrections cannot be used on [51cr]EDTA clearance values below the mean extrarenal clearance, averaging 3.7 ml/min.

Adult↗
PubMed1977

Abdominal scintiphotography with 99mtechnetium-labelled albumin in acute gastrointestinal bleeding. An experimental study and a case-report.

In a new diagnostic method in acute gastrointestinal bleeding, after an intravenous injection of 99mtechnetium-labelled albumin, the distribution of radioactivity in the abdomen is followed for 40-60 minutes by sequential scintiphotography. The site of simulated gastrointestinal bleeding could be identified in all five volunteers. In a patient with severe bleeding from diverticula in the sigmoid colon the method gave a correct estimate of the site of the bleeding and of its rate.

Abdomen↗
PubMed1977

Determination of 58Co-vitamin B12 absorption in pernicious anemia by use of whole-body counting: Reproducibility and control of gut transit time.

In 15 patients with pernicious anemia, the fractional retention of 58Co-cyanocobalamin (FRB12) without administration of intrinsic factor (IF) averaged 4.9% (range 0-12.7). With administration of IF, FRB12 averaged 32.7% (range 26.6--42.3) in the patients and 65.6% (range 38.8--84.6) in 16 control subjects. The gut transit time for vitamin B12 was evaluated from the excretion of radiopaque pellets given concomitantly with the 58Co-vitamin B12. The retention of the pellets was positively correlated to that of the non-absorbed 58Co-B12. Control of the gut transit time is recommended at each examination of FRB12 in order to avoid falsely high values due to the retention of non-absorbed 58Co-B12. We found a good reproducibility of FRB12 when determined in fasting subjects, and it is therefore unnecessary to give the patients a B12-free meal prior to the examination. As the FRB12 in all probability is only a little lower than the fractional absorption, the present method is applicalble for the determination of B12 absorption.

Administration, Oral↗
PubMed1977

Compensatory renal hypertrophia in patients undergoing unilateral nephrectomy.

Estimations of the residual glomerular filtration rate (GFR) were made from renography and GFR measurements before unilateral nephrectomy in 28 patients aged 42-77 years. The GFR was measured one week and three months after the operation and comparisons were made between the function of the remaining kidney and the preoperative estimate. In 23 patients where the removed kidney had some function, the mean GFR increased by 32% and 22% after one week and three months, respectively. In 5 patients where the removed kidney had no function, no compensatory hypertrophy occurred.

Adaptation, Physiological↗