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Biomedical subjects

O Matsui

Publications and source records attributed to O Matsui.

At least 109 records · Page 6Linked to original sources
PubMed1992

Ultrasound visualization of hepatic peribiliary cysts: a comparison with morphology.

We report herein a hitherto unrecognized, interesting ultrasound finding ("hilar multicystic echo complex"), the result of peribiliary cysts in the liver. This ultrasound finding was discovered around intrahepatic large bile ducts and large portal vein branches near the hepatic hilum in an autopsy case with hepatocellular carcinoma, submassive hepatic necrosis superimposed on chronic active hepatitis, and portal hypertension. Antemortem ultrasound examination revealed the hilar multicystic echo complex around the portal venous branches near the hepatic hilum. Autopsy confirmed that the hilar multicystic echo complex was due to peribiliary cysts that were present around the bile ducts at the hilum. The peribiliary cysts were thought to have arisen from cystic dilatation of preexisting intrahepatic peribiliary glands. These peribiliary cysts reportedly occur in livers with portal hypertension (e.g., cirrhosis, hepatocellular carcinoma, idiopathic portal hypertension, extrahepatic portal obstruction, and portal thromboembolism), adult-type polycystic disease of the liver and kidneys, and systemic infection. Therefore, recognition of peribiliary cysts at sonography would have diagnostic value, and may indicate that presence of one of the above described liver diseases.

Adult↗
PubMed1992

The "duct-ectatic" variant of mucinous cystic neoplasm of the pancreas: clinical and radiologic studies of seven cases.

Seven cases of the "duct-ectatic" variant of mucinous cystic neoplasm of the pancreas are presented. This new entity, the duct-ectatic variant of mucinous cystic neoplasm of the pancreas, probably masquerades as pancreatic pseudocyst clinically and radiologically. However, it has the characteristic pathologic findings of the classic "megacystic" type of mucinous cystic neoplasm. If there are cysts visualized on pancreaticogram which are in a diffusely duct-ectatic configuration and are in communication with the main pancreatic duct, the duct-ectatic variant of mucinous cystic neoplasm should be strongly suspected rather than the pancreatic pseudocyst.

Adult↗
PubMed1991

Liver atrophy after transcatheter arterial embolization and percutaneous ethanol injection therapy for a minute hepatocellular carcinoma.

A 63-year-old male patient with compensated cirrhosis underwent transcatheter arterial embolization (TAE) and percutaneous ethanol injection therapy (PEIT) for a minute hepatocellular carcinoma (HCC). Although the HCC was successfully treated, esophageal varices worsened and refractory ascites developed 3 months after the TAE and PEIT. Liver atrophy progressed rapidly compared to the natural course of liver cirrhosis.

Atrophy↗
PubMed1991

Detection by CT during arterial portography of colorectal cancer metastases to liver.

A prospective evaluation of the accuracy of real-time ultrasonography (US), computed tomography (CT), infusion hepatic angiography (IHA), and computed tomography during arterial portography (CT-AP) was performed on 65 resected liver metastases of colorectal cancers. The total detection rate was 58.5 percent for US, 56.3 percent for CT, 55.4 percent for IHA, and 86.2 percent for CT-AP. The sensitivity of 29 lesions with diameters of smaller than 1 cm was 65.5 percent for CT-AP, CT found only two, and both US and IHA localized no more than three. The smallest lesions detectable by CT-AP were as small as 0.4 cm in diameter. CT-AP proved most useful in detecting the liver metastases, and the use of this technique is recommended for preoperative planning of hepatectomy on patients with liver metastases.

Angiography↗
PubMed1991

Well-differentiated hepatocellular carcinoma showing intrahepatic neural invasion: autopsied case.

An autopsied case of well-differentiated hepatocellular carcinoma (HCC), showing neural invasion into the portal tract of the liver, a hitherto undescribed lesion, is reported. The patient, a 68-year-old man, had had treatment for HCC over nine years, comprising surgical resection, transcatheter arterial embolization, transportal venous embolization and percutaneous ethanol injection to nodules of the HCC. At autopsy, many HCC nodules (less than 7 cm in diameter) were found in the liver. In one of them, carcinoma cells infiltrated the medium-sized protal tract among the regenerative nodules and some of these carcinoma cells further invaded nerve fibers. Although the majority of the HCC nodules showed ischemic necrosis, the infiltrating carcinoma cells in the portal tract were viable, suggesting the biological behavior and/or blood supply of these infiltrating carcinoma cells to be different.

Aged↗
PubMed1991

Benign and malignant nodules in cirrhotic livers: distinction based on blood supply.

The blood supplies of nodular lesions associated with liver cirrhosis were analyzed in vivo with various imaging modalities. The portal blood supply was evaluated with computed tomography (CT) during arterial portography (CTAP); the arterial blood supply was evaluated with hepatic angiography, CT angiography, CT following intraarterial injection of iodized oil, or ultrasound following intraarterial injection of carbon dioxide microbubbles. A total of 84 surgically confirmed hepatocellular carcinomas (HCCs) (less than or equal to 3 cm) and 25 areas of adenomatous hyperplasia (AH) were included in the study. At CTAP, a portal blood supply was seen in 96% of cases of AH and only 6% of HCCs (chi 2, P less than .005). In contrast, an arterial supply greater than that of the surrounding liver was verified in 94% of the HCCs and only 4% of the cases of AH (chi 2, P less than .005). The blood supply of areas of AH with atypical hepatocytes and the blood supply of well-differentiated HCCs (Edmondson grade 1) tended to be intermediate between that of AH without atypia and that of HCC that was Edmondson and Steiner grade 2 or greater. Evaluation of the blood supply of the nodular lesions associated with liver cirrhosis is considered to be useful in the differential diagnosis and treatment of early-stage HCC.

Carcinoma, Hepatocellular↗
PubMed1991

Hepatocellular carcinomas with excessive copper accumulation: CT and MR findings.

Results of orcein staining and findings obtained with non-contrast-medium-enhanced computed tomography (CT) and magnetic resonance (MR) imaging (T1- and T2-weighted images) were compared for 53 histologically confirmed hepatocellular carcinomas (HCCs). HCCs were 5 cm in the largest diameter. Three lesions with diffuse and strong orcein staining were highly attenuating on nonenhanced CT images. Electron x-ray microanalysis of one of them revealed copper. The high attenuation value at nonenhanced CT may have been due to the abundant copper-binding protein in the cancer cells. The difference between orcein staining results and attenuation patterns at CT was statistically significant (chi 2, P less than .001). It could not be concluded that the paramagnetic effects of copper in HCC had an influence on signal intensity on MR images. The difference between orcein staining results and signal-intensity patterns on T1- and T2-weighted images was not statistically significant.

Adult↗
PubMed1990

Iron-accumulating adenomatous hyperplastic nodule with malignant foci in the cirrhotic liver. Histopathologic, quantitative iron, and magnetic resonance imaging in vitro studies.

Five iron-accumulating adenomatous hyperplastic nodules (AHN) in cirrhotic livers were examined histologically, by quantitation of tissue iron, and by magnetic resonance imaging (MRI) in vitro. Histologically, one AHN was benign, while the other four contained malignant hepatocellular foci. Iron staining and quantitation of tissue iron revealed that AHN were rich in iron, but the malignant hepatocellular foci and surrounding regenerative nodules were relatively poor in iron. The MRI showed that AHN were hypointense while malignant hepatocellular foci and surrounding regenerative nodules were isointense. Thus, malignant hepatocellular foci within AHN corresponded to iron-poor isointense foci. These findings suggest that malignant hepatocellular foci arising in iron-accumulating AHN are resistant to iron accumulation and that iron-accumulating AHN can be recognized with MRI in vitro as hypointense and malignant foci as isointense.

Aged↗
PubMed1990

[Analysis of the characteristics of responders to chemotherapy of advanced hepatocellular carcinoma].

To evaluate characteristics of the responders to chemotherapy for advanced hepatocellular carcinoma, clinicopathological findings of the responders (9 cases) and those of the non-responders (58 cases) have been compared. As for clinical characteristics, no difference was found in age and sex between the two groups. The responders were, however, restricted to the good cases in respect to performance status (PS) and hepatic reserve based on Child's classification. Concerning characteristics of tumors, no significant difference between the two groups was observed in size and number of tumors, or in the frequency of portal vein thrombosis and that of remote metastasis. There was no difference between them in chemotherapy regimen, either. It was concluded that PS and hepatic reserve might be the most important factors determining the efficacy of chemotherapy for advanced hepatocellular carcinoma.

Adult↗
PubMed1990

'Atypical adenomatous hyperplasia' in liver cirrhosis: low-grade hepatocellular carcinoma or borderline lesion?

Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes similar to those of the surrounding liver, and showed regularly distributed portal tracts. The latter type was composed of hepatocytes showing nuclear atypia, relative to the surrounding liver, and showed irregular or sparse portal tracts. Atypical nodules were histologically heterogeneous, possessing areas of normo-trabecular, compact, pseudoglandular and/or scirrhous patterns. Several cytological changes, such as clear cell change, small or large cell change and fatty change, were intermingled variably within a given nodule. Atypical nodules showed expansive and/or replacing growth into the surrounding liver. Atypical hepatocytes also infiltrated into the fibrous septa and portal tracts. Foci of overt hepatocellular carcinoma were found in 11 of the 53 atypical nodules. These findings suggest that ordinary adenomatous hyperplasia may be a large-sized regenerative nodule, while atypical adenomatous hyperplasia may be a hepatocellular neoplasm, a peculiar form of low-grade hepatocellular carcinoma or borderline lesion, in which overt hepatocellular carcinoma is likely to evolve through multiple steps.

Adult↗
PubMed1990

Ciliated hepatic foregut cyst: radiologic features.

Ciliated hepatic foregut cysts (CHFCs) are solitary unilocular cysts in the liver that are histologically similar to bronchogenic cysts. Three cases of CHFC are reported that demonstrated radiologic features similar to those of solid masses. All the lesions were smaller than 3 cm in diameter and were subcapsular. At ultrasonography, one lesion appeared anechoic but the other two were hypoechoic. Unenhanced computed tomography demonstrated the lesions to be hyperattenuating or isoattenuating relative to surrounding liver parenchyma, and no lesions enhanced with administration of contrast material. Magnetic resonance imaging was performed in one case and demonstrated the lesion to be markedly hyperintense with a spin-echo (SE) 2,500/80 (repetition time msec/echo time msec) sequence. All the lesions were resected and found to be filled with viscous mucinous fluid. The CHFCs are not neoplasms and must be differentiated from cystic neoplasms and hypovascular solid tumors. When a subcapsular lesion demonstrated the varied appearance described, a diagnosis of CHFC should be considered.

Aged↗
PubMed1990

[Intra-hepato-arterial infusion chemotherapy using catheter inserted and placed in hepatic artery via the left radial artery on liver malignancy].

A catheter (5Fr) was inserted and placed via the left radial artery in the common or proper hepatic artery for intra-hepato-arterial infusion chemotherapy in 26 cases of liver malignancy. The patients for the chemotherapy included 15 cases of primary hepatocellular carcinoma, five cases of metastatic gastric carcinoma, 3 cases of metastatic colorectal carcinoma, one case of metastatic leiomyosarcoma, one case of metastatic bile duct carcinoma and one case of metastatic melanoma. A large-bore catheter was successfully inserted via the left radial artery, and transcatheter arterial embolization therapy (TAE) was performed on 8 cases during the infusion chemotherapy using the same catheter. One case developed cerebellar infarction after the insertion of the catheter, but no other serious complication developed during the therapy using this technique. It is easy to insert or remove the catheter via the left radial artery. This technique is useful in intra-hepato-arterial infusion chemotherapy on liver malignancy.

Adolescent↗
PubMed1990

[An operated case of multiple well-differentiated hepatocellular carcinomas and adenomatous hyperplasia].

A 66-year-old male with non-A, non-B liver cirrhosis underwent an operation for a partial resection of the S8 area. Intraoperative ultrasound (US) examination of the entire liver revealed 10 space-occupying lesions (SOLs), and a biopsy of 5 out of the 10 SOLs showed 3 hepatocellular carcinomas (HCCs), adenomatous hyperplasia (AH), and an atypical AH (AAH). In a resected specimen that including 4 SOLs that had been detected by operative US, 6 early HCCs, an HCC of the Edmondson grade I + II, and 2 AAHs were found. All tumors were less than 2 cm and were not encapsulated.

Aged↗